Subject(s)
Lipoma/diagnostic imaging , Tongue Neoplasms/diagnostic imaging , Humans , Male , Middle Aged , UltrasonographySubject(s)
Facial Dermatoses/diagnosis , Fasciitis/diagnosis , Child , Diagnosis, Differential , Epidermal Cyst/diagnosis , Eyebrows , Facial Dermatoses/diagnostic imaging , Facial Dermatoses/pathology , Facial Neoplasms/diagnosis , Fasciitis/diagnostic imaging , Fasciitis/pathology , Female , Fibroblasts/pathology , Humans , Myofibroblasts/pathology , Subcutaneous TissueSubject(s)
Histiocytoma, Benign Fibrous/diagnostic imaging , Skin Neoplasms/diagnostic imaging , Ultrasonography, Doppler , Abdomen , Adult , Arm , Carcinoma, Squamous Cell , Female , Histiocytoma, Benign Fibrous/blood supply , Humans , Male , Middle Aged , Neoplasms, Second Primary/diagnostic imaging , Pharyngeal Neoplasms , Skin Neoplasms/blood supplySubject(s)
Adrenal Insufficiency/complications , Calcinosis/etiology , Ear Cartilage/pathology , Adrenal Insufficiency/blood , Adrenal Insufficiency/diagnosis , Adrenocorticotropic Hormone/blood , Calcinosis/diagnostic imaging , Ear Cartilage/diagnostic imaging , Humans , Hydrocortisone/blood , Hydrocortisone/metabolism , Hyponatremia/etiology , Male , Middle AgedSubject(s)
Sarcoma/pathology , Skin Neoplasms/pathology , Aged, 80 and over , Diagnosis, Differential , Female , Forehead , HumansSubject(s)
Edema/etiology , Eosinophilia/complications , Fasciitis/complications , Humans , Male , Middle AgedABSTRACT
Introducción: La leishmaniasis, infección endémica en España, está causada por protozoos del género Leishmania. Durante los años 2010-2012 hubo un brote de leishmaniasis cutánea y visceral en Fuenlabrada, Madrid. Objetivos: Describir los casos de leishmaniasis cutánea (LC) diagnosticados durante 17 meses en el Servicio de Dermatología del Hospital de Fuenlabrada. Material y métodos: Estudiamos variables epidemiológicas, clínicas, histológicas, microbiológicas y terapéuticas de cada caso. Resultados: Se recogieron 149 pacientes. Encontramos una incidencia similar en varones que en mujeres, la edad más frecuente fue entre 46-60 años. El tiempo de evolución presentaba un pico de máxima frecuencia entre los 2 y 6 meses. La forma clínica más habitual fue la de pápulas y placas eritematosas sin costra (52%). En el 57% de los casos las lesiones eran múltiples. La localización más común fue en áreas fotoexpuestas. El estudio histológico mostró en el 67% de los pacientes una dermatitis granulomatosa no necrotizante sin parásitos con tinciones habituales. La reacción en cadena de la polimerasa (PCR) para Leishmania confirmó el diagnóstico en el 98% de los casos. En los demás el estudio histológico de la piel identificó cuerpos de leishmanias. Los antimoniales pentavalentes intralesionales fueron los fármacos más empleados (76%), con resultado satisfactorio. Conclusiones: Presentamos una serie amplia de casos de LC en el contexto de un brote. La forma más habitual fue la aparición de múltiples pápulas, y la forma histológica la dermatitis granulomatosa no necrotizante, en la que no se observaron leishmanias. La PCR en piel fue la prueba más importante para alcanzar el diagnóstico (AU)
Introduction: Leishmaniasis, an endemic infection in Spain, is caused by protozoan parasites of the Leishmania genus. Between 2010 and 2012, there was an outbreak of cutaneous and visceral leishmaniasis in Fuenlabrada, Madrid. Objectives: To describe the cases of cutaneous leishmaniasis diagnosed over a 17-month period at the dermatology department of Hospital de Fuenlabrada. Material and methods: We analyzed the epidemiological, clinical, histological, and microbiological features of each case and also evaluated the treatments administered and outcomes. Results: We studied 149 cases. The incidence of cutaneous leishmaniasis showed a peak in the age range between 46 and 60 years and was similar in men and women. At the time of consultation, the lesions had been present for between 2 and 6 months in the majority of patients. The most common clinical presentation was with erythematous plaques and papules without crusts (52% of cases). Lesions were most often located in sun-exposed areas and were multiple in 57% of patients. In 67% of cases, the histological study showed non-necrotizing granulomatous dermatitis with no evidence of parasites using conventional staining methods. Diagnosis was confirmed by polymerase chain reaction (PCR) in 98% of patients. In the remaining cases, the histological study revealed Leishman-Donovan bodies in the skin. Intralesional pentavalent antimonials were the most commonly used drugs (76% of cases) and produced satisfactory results. Conclusions: We have presented a large series of cases of cutaneous leishmaniasis diagnosed in the context of an outbreak. Multiple papules were the most common clinical presentation, with histology that showed non-necrotizing granulomatous dermatitis with no evidence of parasites. PCR of skin samples was the test that most frequently provided the diagnosis (AU)
Subject(s)
Humans , Female , Middle Aged , Leishmaniasis/epidemiology , Seedlings/physiology , Polymerase Chain Reaction/instrumentation , Polymerase Chain Reaction/methods , Polymerase Chain Reaction , Immunosuppression Therapy/instrumentation , Immunosuppression Therapy/methods , Polymerase Chain Reaction/standards , Polymerase Chain Reaction/trends , Radiography, Thoracic/methods , Radiography, ThoracicABSTRACT
BACKGROUND: Leishmaniasis, an endemic infection in Spain, is caused by protozoan parasites of the Leishmania genus. Between 2010 and 2012, there was an outbreak of cutaneous and visceral leishmaniasis in Fuenlabrada, Madrid. OBJECTIVES: To describe the cases of cutaneous leishmaniasis diagnosed over a 17-month period at the dermatology department of Hospital de Fuenlabrada. MATERIAL AND METHODS: We analyzed the epidemiological, clinical, histological, and microbiological features of each case and also evaluated the treatments administered and outcomes. RESULTS: We studied 149 cases. The incidence of cutaneous leishmaniasis showed a peak in the age range between 46 and 60 years and was similar in men and women. At the time of consultation, the lesions had been present for between 2 and 6 months in the majority of patients. The most common clinical presentation was with erythematous plaques and papules without crusts (52% of cases). Lesions were most often located in sun-exposed areas and were multiple in 57% of patients. In 67% of cases, the histological study showed non-necrotizing granulomatous dermatitis with no evidence of parasites using conventional staining methods. Diagnosis was confirmed by polymerase chain reaction (PCR) in 98% of patients. In the remaining cases, the histological study revealed Leishman-Donovan bodies in the skin. Intralesional pentavalent antimonials were the most commonly used drugs (76% of cases) and produced satisfactory results. CONCLUSIONS: We have presented a large series of cases of cutaneous leishmaniasis diagnosed in the context of an outbreak. Multiple papules were the most common clinical presentation, with histology that showed non-necrotizing granulomatous dermatitis with no evidence of parasites. PCR of skin samples was the test that most frequently provided the diagnosis.
Subject(s)
Disease Outbreaks , Leishmaniasis, Cutaneous/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Female , Humans , Infant , Male , Middle Aged , Spain/epidemiology , Urban Health , Young AdultSubject(s)
Fibroma/pathology , Head and Neck Neoplasms/pathology , Lipoma/pathology , Neuroma/pathology , Skin Neoplasms/pathology , Humans , Male , Middle AgedABSTRACT
Eosinophilic polymorphic and pruritic eruption associated with radiotherapy (EPPER) is a rare entity that appears in oncological patients after radiotherapy. We describe two patients with breast tumour who presented with EPPER in a different area from the one that had been irradiated. One of them needed different types of treatment, topical and systemic corticosteroids, antihistamines and narrowband ultraviolet B. The other one responded to the application of topical corticosteroids. We suggested that this eruption could be more frequent than has been reported.
Subject(s)
Breast Neoplasms/radiotherapy , Eosinophilia/etiology , Pruritus/etiology , Radiodermatitis/pathology , Combined Modality Therapy , Eosinophilia/therapy , Female , Humans , Middle Aged , Pruritus/therapy , Radiodermatitis/therapySubject(s)
Bile Duct Neoplasms/diagnosis , Bile Ducts/innervation , Neuroma/diagnosis , Female , Humans , Middle AgedABSTRACT
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