ABSTRACT
BACKGROUND: Only few studies have been done to evaluate level of serum immunoglobulins (IgG,IgM,IgA) in patients with Potentially Malignant Disorders (PMD) like Leukoplakia, Oral Submucous Fibrosis (OSMF) and Oral Lichen Planus (OLP) as tumour markers. AIMS AND OBJECTIVES: To estimate the serum immunoglobulins level (IgG, IgM, IgA) in leukoplakia, OSMF and oral lichen planus (OLP) patients and its comparison with levels among control groups and Weather these values can be used to predict severity of disease or not. MATERIALS AND METHODS: 30 patients with different potentially malignant disorders like leukoplakia, OSMF and oral lichen planus and 30 healthy controls were selected at random and subjected for analysis of serum IgG, IgA, IgM. Statistical methods employed were mean, standard deviation and ANOVA test. RESULTS: We observed significant elevated levels of all the immunoglobulins in leukoplakia, OSMF and oral lichen planus when compared with the control group and levels were increasing with clinical stages of OSMF (p < 0.05). CONCLUSIONS: All these immunoglobulins are indicative of tumour burden or transformation of malignancy in higher stage and might be employed as prognostic indicators in these disorders.
ABSTRACT
Localized gingival enlargement is often associated with systemic medications, abscess formation, trauma, or reactive lesions. Very few reports are available reporting enlargement of gingiva due to metastasis of adenocarcinoma of the esophagus. A case of localized gingival growth affecting right maxillary and mandibular gingiva was reported in a 60-year-old male patient in which excisional biopsy of the lesion was done. Histopathological examination showed metastatic signet ring cell adenocarcinoma, which on further examination showed lower one-third of esophagus as the primary site of metastasis.
