Association of Adipokines, Insulin Resistance, Hypertension and Dyslipidemia in Patients with Psoriasis Vulgaris.

BACKGROUND: Systemic inflammation in psoriasis causes insulin resistance and cardiovascular diseases. Adipokines are adipose-tissue-derived factors that are involved in metabolic processes. It is thought that these adipokines are associated with the development of psoriasis. OBJECTIVE: The purpose of this study was to determine the changes in adipokine levels, insulin resistance, hypertension, and dyslipidemia over a 12-week period. METHODS: The study comprised 35 psoriasis patients and 50 controls. Blood samples were obtained twice from the patients, one sample at the start and one at the end of a 12-week follow-up period. The following parameters were assessed in both groups: serum fasting glucose, fasting insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, serum lipids, adiponectin, leptin, resistin, chemerin, omentin, vaspin, visfatin, retinol-binding protein 4, and high-sensitivity C-reactive protein (hs-CRP) levels; blood pressure; body mass index; and the psoriasis area severity index (PASI) scores. RESULTS: The patients showed an improvement in the PASI score and a significant decrease in serum hs-CRP, omentin, and chemerin values. Moreover, at the start of the follow-up, the psoriasis patients had significantly lower levels of adiponectin and visfatin and significantly higher levels of vaspin and resistin than those of the control group. Visfatin levels correlated negatively with low-density lipoprotein (LDL) and cholesterol, while vaspin and omentin levels correlated positively with diastolic blood pressure. Decreased adiponectin levels correlated negatively with diastolic blood pressure and LDL. CONCLUSION: Plasma levels of adipokines might be useful for evaluating the disease activity of psoriasis and its comorbidities.

Influence of narrowband UVB irradiation of serum on autologous serum skin test results.

BACKGROUND: Autologous serum skin test (ASST) is an in vivo test to demonstrate circulating endogenous proinflammatory or wheal-inducing factors in urticaria patients. While ASST was negative in a patient with solar urticaria and in a patient with localized heat urticaria, test results turned to positive when performed with visible light-irradiated and heated serums, respectively. These data suggest that some factors and/or antibodies in serum may be activated or inhibited with different factors. We aimed to investigate whether or not ASST results change when performed with narrowband ultraviolet B (UVB)-irradiated serum. MATERIALS AND METHODS: Seventy-seven patients with chronic idiopathic urticaria underwent ASST twice in consecutive days. The second ASST was performed with narrowband UVB-irradiated serum. The results of the first and second ASSTs were compared. RESULTS: The first ASST results were positive in 46 (59.7%) patients. ASST results reversed oppositely in 36 (46.8%) patients, turned from negative to positive in 19 patients, and turned from positive to negative in 17 patients when performed with narrowband UVB-irradiated serum. CONCLUSION: Our results suggest that narrowband UVB may have modifying effects on some wheal-inducing factors and/or antibodies. On which factors in serum narrowband UVB has effects may be investigated.

Scientific productivity of OECD countries in dermatology journals within the last 10-year period.

BACKGROUND: Scientific productivity is closely related to gross income, population, and cultures of the countries. Every country, more or less, has a responsibility of contributing to science. MATERIALS AND METHODS: The publications, citations received, and the h-index under the category of "dermatology" in 43 journals between the years of 1999-2003 and 2004-2008 according to the ISI JCR data of 2008 were examined individually for each OECD country. RESULTS: In the journals under the category of "dermatology" between the years of 1999 and 2008, there were 89,319 publications, 76,899 of which were published by OECD countries. USA ranks first with 27,109 publications and 196,002 citations; Germany, Japan, England, and France are the other countries among the top five, respectively. Regarding the number of publications, Turkey and Korea are among the top 10 by surpassing many Northern European countries. With regard to h-index and citations, Northern European countries and Canada rank among the top 10, while Japan, Spain, Turkey, and Korea rank behind. The number of publications showed a significant correlation with the number of citations, population, gross domestic product, and h-index. CONCLUSIONS: Nearly half of all publications were performed by the European origin OECD countries, and one-third of all publications were performed by USA. Journals from Germany and France, which are published in their own language, receive fewer citations, but they contribute a lot to these countries with respect to the number of publications.

The role of various immersion liquids at digital dermoscopy in structural analysis.

BACKGROUND: Dermoscopy is a useful method that allows dermal and epidermal structures to be easily analysed non-invasively. AIM: In this study, immersion oil, which is widely used in dermoscopy, and ultrasound gel, which is less preferred, are evaluated comparatively in terms of displaying structural parameters and number of air bubbles in the image. METHODS: A total of 71 nevomelanocytic or non-melanocytic pigmented lesions were taken up for this study. Structural characteristics of the obtained images were assessed by an experienced observer who scored the images in terms of color, pigment network, globule, vascular structure, number of air bubbles and other pigmentation parameters. RESULTS: In the images obtained through immersion oil or ultrasound gel from all of the lesions, no statistical difference was found between the average values of air bubbles and in the evaluation of structural components (t=1.09, P=0.2). In the identification of pigment network in melanocytic lesions, immersion oil was observed to be more appropriate than ultrasound gel (t=0.01, P=0.02). CONCLUSIONS: Ultrasound gel may be preferred in the assessment of mucosa and nail bed lesions. Ultrasound gel is a good alternative compared to immersion oil in pigmented skin lesions as it is cheap and easily removable.

HIV-negative case of bacillary angiomatosis with chronic hepatitis B.

Bacillary angiomatosis (BA) is an infectious disease which occurs predominantly in immunosuppressive patients and rarely in immunocompetent individuals. We had a case of BA who presented with a red cutaneous nodule on his left leg of which histopathological examination revealed marked lobular proliferation of capillaries throughout the interstitium and clusters of bacilli with hematoxylin-eosin and Warthin-Starry stains, respectively. Antibody titer against Bartonella henselae was 1/32. The only systemic disease the patient had was chronic hepatitis B. HIV was negative and no other immunosuppressive status was established. In this case we believe that the immunological differences secondary to chronic hepatitis B could have caused a tendency for the disease development.

Paraffinoma and ulcer of the external genitalia after self-injection of vaseline.

We present a 42-year-old circumcised man with a 10-cm firm, irregular penile mass associated with multiple penile ulcers, voiding difficulty, and erectile dysfunction. He reluctantly admitted that 8 months previously, he had multiple mineral-oil (vaseline) self-injections to the penis, for penile enlargement purposes. Histopathological examination revealed the condition was consistent with mineral-oil granuloma (paraffinoma). The patient did not accept surgical intervention; therefore, we performed local therapy (intralesional triamcinolone) and hot-water baths. Paraffinoma results from mineral-oil injections. Such injections are rare; however, they are still being performed in some countries in Eastern Europe and the Far East such as Korea. Increased physician and public awareness are needed for prevention and treatment of complications of this physically and psychologically debilitating and destructive problem.