ABSTRACT
The hepatitis B virus is responsible for most of the chronic liver disease and liver cancer worldwide. As actual therapeutic strategies have had little success in eradicating the virus from hepatocytes, and as lifelong treatment is often required, new drugs targeting the various phases of the hepatitis B virus (HBV) lifecycle are currently under investigation. In this review, we provide an overview of potential future treatments for HBV.
Subject(s)
Hepatitis B virus , Hepatitis B, Chronic/therapy , Hepatitis B/therapy , Animals , Antiviral Agents/pharmacology , Genetic Therapy , Hepatitis B Vaccines , Hepatitis B, Chronic/virology , Hepatocytes/virology , Humans , Immunotherapy , Life Cycle StagesABSTRACT
Chronic Hepatitis C is associated with many extrahepatic manifestations. Central nervous system is frequently involved, but the pathophysiological mechanisms are not fully understood. Local and systemic inflammation, ischemia, immune-mediated phenomena have been described in this context. Clinical manifestations include cognitive alterations, stroke, depression and demyelinating phenomena. It is unclear if cognitive deficits can be improved or resolved with viral eradication and to understand this, could have important therapeutical implications.
Subject(s)
Hepatitis C, Chronic/complications , Mental Disorders/etiology , Nervous System Diseases/etiology , Brain/metabolism , Central Nervous System Diseases/etiology , Cognition Disorders/etiology , Depression/etiology , Hepacivirus , Humans , Infectious Encephalitis/etiology , Inflammation/complications , Neuroglia , Peripheral Nervous System Diseases/etiology , Quality of Life , Stroke/etiologyABSTRACT
A dataset of measurements of ETSI ITS-G5 Dedicated Short Range Communications (DSRC) is presented. Our dataset consists of network interactions happening between two On-Board Units (OBUs) and four Road Side Units (RSUs). Each OBU was fitted onto a vehicle driven across the FLOURISH Test Track in Bristol, UK. Each RSU and OBU was equipped with two transceivers operating at different frequencies. During our experiments, each transceiver broadcasts Cooperative Awareness Messages (CAMs) over the licensed DSRC band, and over the unlicensed Industrial, Scientific, and Medical radio (ISM) bands 2.4 GHz-2.5 GHz and 5.725 GHz-5.875 GHz. Each transmitted and received CAM is logged along with its Received Signal Strength Indicator (RSSI) value and accurate positioning information. The Media Access Control layer (MAC) layer Packet Delivery Rates (PDRs) and RSSI values are also empirically calculated across the whole length of the track for any transceiver. The dataset can be used to derive realistic approximations of the PDR as a function of RSSI values under urban environments and for both the DSRC and ISM bands - thus, the dataset is suitable to calibrate (simplified) physical layers of full-stack vehicular simulators where the MAC layer PDR is a direct function of the RSSI. The dataset is not intended to be used for signal propagation modelling. The dataset can be found at https://doi.org/10.5523/bris.eupowp7h3jl525yxhm3521f57, and it has been analyzed in the following paper: I. Mavromatis, A. Tassi, and R. J. Piechocki, "Operating ITS-G5 DSRC over Unlicensed Bands: A City-Scale Performance Evaluation," IEEE PIMRC 2019. [Online]. Available: https://arxiv.org/abs/1904.00464.
