ABSTRACT
In patients with Systemic lupus erythematosus (SLE), Raynaud phenomenon (RP) is frequently present and associated with pulmonary hypertension (PHT). Elevated pulmonary artery systolic pressure (PASP) is an indicator of PHT and can be estimated noninvasively. We attempt to explore the significance of RP in SLE and to correlate it with clinical and serological parameters of the disease. The study population consisted of 34 patients (age, sex and disease duration matched) who fulfilled the revised SLE criteria of the American College of Rheumatology, and were categorized into two groups: Group 1 had patients having SLE and RP (2 males/15 females, mean age 45 +/- 18 years) and group 2 had patients with SLE but without RP (3 males/14 females, mean age 40 +/- 14 years. Detailed cardiac ultrasound was performed including measurement of PASP, while clinical and serological features of both groups were collected and correlated. Significant differences were shown in the presence of arterial hypertension (P < 0.05), arthralgias (P < 0.005), arthritis (P < 0.05), myalgias (P < 0.05), alopecia (P < 0.05) and PASP (P < 0.0001). No difference was observed among the cardiac ultrasound indices and the ejection fraction between the two groups. PASP was significantly correlated with RP, while no correlation was observed regarding the disease duration. In patients with SLE, the presence of RP was associated with elevation in PASP. Further investigation is needed to clarify the significance of this relation.
Subject(s)
Hypertension, Pulmonary/etiology , Lupus Erythematosus, Systemic/physiopathology , Pulmonary Wedge Pressure/physiology , Raynaud Disease/physiopathology , Adult , Echocardiography , Female , Follow-Up Studies , Humans , Hypertension, Pulmonary/diagnostic imaging , Hypertension, Pulmonary/physiopathology , Lupus Erythematosus, Systemic/complications , Male , Middle Aged , Prognosis , Raynaud Disease/complications , Raynaud Disease/diagnostic imaging , Severity of Illness Index , Systole , Time FactorsSubject(s)
Osteolysis/diagnostic imaging , Polycythemia Vera/diagnostic imaging , Primary Myelofibrosis/diagnostic imaging , Aged , Fatal Outcome , Humans , Magnetic Resonance Imaging , Male , Osteolysis/blood , Osteolysis/etiology , Osteolysis/pathology , Polycythemia Vera/blood , Polycythemia Vera/complications , Polycythemia Vera/pathology , Primary Myelofibrosis/blood , Primary Myelofibrosis/etiology , Primary Myelofibrosis/pathology , Tomography, X-Ray ComputedSubject(s)
Antibodies, Monoclonal/adverse effects , Antirheumatic Agents/adverse effects , Arthritis, Rheumatoid/drug therapy , Fever of Unknown Origin/etiology , Aged , Antibodies, Monoclonal/immunology , Antirheumatic Agents/immunology , Female , Humans , Infliximab , Time Factors , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Tumor Necrosis Factor-alpha/immunologyABSTRACT
The aim of this study was to assess the erythropoietic response to hypoxaemia in patients with diffuse idiopathic pulmonary fibrosis (DIPF), and to speculate on the underlying mechanisms. Patients on an established chronic respiratory failure due to DIPF or chronic obstructive pulmonary disease (COPD) were studied. The erythropoietic response to hypoxaemia in both conditions was assessed. We studied 18 patients with DIPF and 29 patients with COPD in respiratory failure in a stable stage, free from acute infection and congestive heart failure. Blood gases, erythrocytic parameters, as well the serum levels of iron, ferritin and erythropoietin were determined. All the DIPF patients studied, apart from two, had normal or subnormal haematocrit values. The patients with COPD had an inconsistant response to hypoxaemia; 12 had normal or subnormal haematocrit values and the remaining 17 were erythraemic. The mean value of erythropoietin (EPO) in both DIPF and COPD patients was significantly higher than normal. In conclusion, patients with DIPF exhibit a lack of erythropoietic response to hypoxaemia, despite the augmented erythropoietin levels. This may reflect a defective bone marrow erythropoietic response in DIPF patients. It is suggested that the pathophysiology of DIPF underlies this mechanism.
Subject(s)
Erythropoiesis/physiology , Hypoxia/physiopathology , Lung Diseases, Obstructive/physiopathology , Pulmonary Fibrosis/physiopathology , Adult , Aged , Aged, 80 and over , Blood Gas Analysis , Erythropoietin/blood , Female , Ferritins/blood , Hematocrit , Humans , Hypoxia/blood , Hypoxia/etiology , Iron/blood , Lung Diseases, Obstructive/blood , Lung Diseases, Obstructive/complications , Male , Middle Aged , Pulmonary Fibrosis/blood , Pulmonary Fibrosis/complications , Reference Values , Regression AnalysisABSTRACT
A case of pyomyositis is presented. This case is unique in the literature as at least 29 abscesses were detected, affecting the vast majority of big muscle groups. We outline the origin of this disease entity which selectively affects striated muscles. We also discuss its natural history and management strategy.
Subject(s)
Polymyositis/diagnosis , Polymyositis/therapy , Staphylococcal Infections/diagnosis , Staphylococcal Infections/therapy , Aged , Anti-Bacterial Agents , Combined Modality Therapy , Drug Therapy, Combination/therapeutic use , Female , Humans , Staphylococcus aureus/isolation & purification , Suction , Treatment OutcomeABSTRACT
Adamantiades-Behçet's disease is a multisystem recurrent syndrome with vasculitis being the underlying histopathological lesion. We report on a patient with Behçet's disease who developed a renal mass raising the suspicion of a malignant neoplasm. The pathologic examination revealed an inflammatory pseudotumor. The concurrent presentation of these two entities seems to be more than coincidental.
Subject(s)
Behcet Syndrome/complications , Granuloma, Plasma Cell/pathology , Kidney Diseases/pathology , Diagnosis, Differential , Granuloma, Plasma Cell/surgery , Humans , Kidney Diseases/surgery , Male , Middle AgedABSTRACT
METHODS: We measured the 2,3-diphosphoglycerate inraerythrocytic concentration in 24 normal controls and in 24 hypertensives before and following drug therapy. RESULTS: In hypertensives the 2,3-diphosphoglycerate concentration was higher than that of the controls (14.96 mumol/g Hb vs 13.26 mumol/g Hb respectively); the difference is statistically significant (p < 0.001). Following control of the hypertension by drug therapy, the 2,3 DPG levels in the patients studied do not seem to differ statistically from those of the controls. CONCLUSIONS: This may be a consequence of lower cardiac output in hypertension which results to a lower tissue perfusion, leading to an increased concentration of deoxygenated haemoglobin in the vein blood. Measurement of 2,3-diphosphoglucerate may prove of value in estimating tissue perfusion in hypertension.
Subject(s)
2,3-Diphosphoglycerate/blood , Erythrocytes/metabolism , Hypertension/blood , Hypertension/drug therapy , Adult , Humans , Middle AgedABSTRACT
Erythropoietin levels were determined in 50 Greek females: 20 beta-thalassaemia (beta-thal) heterozygotes, 15 with a diagnosis of iron-deficiency anaemia and 15 normal controls. In beta-thal trait carriers, the erythropoietin levels were slightly higher than in normal controls (16.65 +/- 4.43 vs. 12.84 +/- 2.47 mU/ml); these levels were significantly lower than those in iron-deficient subjects with the same degree of anaemia (55.24 +/- 31.35 mU/ml). In both groups, the erythropoietin levels are statistically correlated with the severity of anaemia (r = -0.537 p < 0.05 for iron deficiency; r = -0.610 p < 0.01 for beta-thal heterozygotes). In beta-thal heterozygotes, a close inverse correlation with red cell number and erythropoietin levels was also noted. It is suggested that microcytosis accompanying beta-thal trait constitutes an additional factor intervening in the regulation of erythropoiesis.
Subject(s)
Anemia, Iron-Deficiency/blood , Erythropoietin/blood , beta-Thalassemia/blood , Adult , Anemia, Iron-Deficiency/physiopathology , Female , Heterozygote , Humans , beta-Thalassemia/physiopathologyABSTRACT
In 45 beta-thalassaemia heterozygotes and in 38 normal controls we determined by ultrasound tomography: (a) the surface of the projection of the spleen to thoracic and abdominal wall, (b) the maximum diameters of the organ, and (c) its volume. The volume of the spleen is significantly bigger in heterozygotes as opposed to normals (132.94 +/- 41.76 and 80.29 +/- 25.88, respectively). In 17.8% of heterozygotes a palpable spleen was found. The findings of this study lead to the hypothesis that in all heterozygotes the final volume of the organ is increased; however, in only 17.8% of them a palpable spleen is found.