Permanent fluidic magnets for liquid bioelectronics.

Brownian motion allows microscopically dispersed nanoparticles to be stable in ferrofluids, as well as causes magnetization relaxation and prohibits permanent magnetism. Here we decoupled the particle Brownian motion from colloidal stability to achieve a permanent fluidic magnet with high magnetization, flowability and reconfigurability. The key to create such permanent fluidic magnets is to maintain a stable magnetic colloidal fluid by using non-Brownian magnetic particles to self-assemble a three-dimensional oriented and ramified magnetic network structure in the carrier fluid. This structure has high coercivity and permanent magnetization, with long-term magnetization stability. We establish a scaling theory model to decipher the permanent fluid magnet formation criteria and formulate a general assembly guideline. Further, we develop injectable and retrievable permanent-fluidic-magnet-based liquid bioelectronics for highly sensitive, self-powered wireless cardiovascular monitoring. Overall, our findings highlight the potential of permanent fluidic magnets as an ultrasoft material for liquid devices and systems, from bioelectronics to robotics.

A multimodal magnetoelastic artificial skin for underwater haptic sensing.

Future exploitation of marine resources in a sustainable and eco-friendly way requires autonomous underwater robotics with human-like perception. However, the development of such intelligent robots is now impeded by the lack of adequate underwater haptic sensing technology. Inspired by the populational coding strategy of the human tactile system, we harness the giant magnetoelasticity in soft polymer systems as an innovative platform technology to construct a multimodal underwater robotic skin for marine object recognition with intrinsic waterproofness and a simple configuration. The bioinspired magnetoelastic artificial skin enables multiplexed tactile modality in each single taxel and obtains an impressive classification rate of 95% in identifying seven types of marine creatures and marine litter. By introducing another degree of freedom in underwater haptic sensing, this work represents a milestone toward sustainable marine resource exploitation.

In Situ Grown Silver-Polymer Framework with Coordination Complexes for Functional Artificial Tissues.

Self-sensing actuators are critical to artificial robots with biomimetic proprio-/exteroception properties of biological neuromuscular systems. Existing add-on approaches, which physically blend heterogeneous sensor/actuator components, fall short of yielding satisfactory solutions, considering their suboptimal interfaces, poor adhesion, and electronic/mechanical property mismatches. Here, a single homogeneous material platform is reported by creating a silver-polymer framework (SPF), thus realizing the seamless sensing-actuation unification. The SPF-enabled elastomer is highly stretchable (1200%), conductive (0.076 S m-1 ), and strong (0.76 MPa in-strength), where the stretchable polymer matrix synthesis and in situ silver nanoparticles reduction are accomplished simultaneously. Benefiting from the multimodal sensing capability from its architecture itself (mechanical and thermal cues), self-sensing actuation (proprio-deformations and external stimuli perceptions) is achieved for the SPF-based pneumatic actuator, alongside an excellent load-lifting attribute (up to 3700 times its own weight), substantiating its advantage of the unified sensing-actuation feature in a single homogenous material. In view of its human somatosensitive muscular systems imitative functionality, the reported SPF bodes well for use with next-generation functional tissues, including artificial skins, human-machine interfaces, self-sensing robots, and otherwise dynamic materials.

Spherical Magnetoelastic Generator for Multidirectional Vibration Energy Harvesting.

Vibration is a common, usually wasted energy, and an attractive target for sustainable electricity generation. In this work, we introduce a new working mechanism to the vibration energy harvesting community by contributing a spherical magnetoelastic generator (S-MEG), which permits multidirectional vibration and is highly adaptable to many natural oscillation frequencies, exhibiting a resonant frequency of 24 Hz and a relatively wide working bandwidth of 15 Hz in the low-frequency range. It also features a low internal impedance of 70 Ω, which can respectively deliver a maximum short-circuit current density of 7.962 A·m-2 and a power density of 15.1 mW·m-2. To demonstrate the capability of S-MEG for ambient vibration energy harvesting, a 220 µF commercial capacitor was successfully charged to 2 V within 25 s, sustainably driving wearable bioelectronics for multiple physiological information monitoring. It could also harvest multidirectional vibration energy from both hand-shaking and bicycle-riding, generating approximately 2.5 mA and 6 mA alternating current from the motions, respectively, even with heavy perspiration or on a rainy day without the need for encapsulation. In summary, this work brings forth an appealing platform technology to the community of vibration energy harvesting, holding a collection of compelling features, including high current density, low inner impedance, intrinsic waterproofness, and scalability for large-scale vibration energy harvesting.

Self-Powered Programming of Fibroblasts into Neurons via a Scalable Magnetoelastic Generator Array.

Developing scalable electrical stimulating platforms for cell and tissue engineering applications is limited by external power source dependency, wetting resistance, microscale size requirements, and suitable flexibility. Here, a versatile and scalable platform is developed to enable tunable electrical stimulation for biological applications by harnessing the giant magnetoelastic effect in soft systems, converting gentle air pressure (100-400 kPa) to yield a current of up to 10.5 mA and a voltage of 9.5 mV. The platform can be easily manufactured and scaled up for integration in multiwell magnetoelastic plates via 3D printing. The authors demonstrate that the electrical stimulation generated by this platform enhances the conversion of fibroblasts into neurons up to 2-fold (104%) and subsequent neuronal maturation up to 3-fold (251%). This easily configurable electrical stimulation device has broad applications in high throughput organ-on-a-chip systems, and paves the way for future development of neural engineering, including cellular therapy via implantable self-powered electrical stimulation devices.

Harvesting Hydropower via a Magnetoelastic Generator for Sustainable Water Splitting.

Energy consumption and the resulting climate change are the two major challenges to human sustainability. Hydrogen (H2) is a form of environmentally friendly renewable energy with an extremely high energy density of 143 MJ kg-1. Water splitting is a practical and cost-effective approach to generate H2 through the decomposition of H2O by electrolysis with an external power supply. Herein, we introduce a compelling platform technology for self-powered water splitting by using a soft magnetoelastic generator to convert hydropower into electricity as a sustainable power supply for electrolysis. At a rotating speed of 469 rpm, the hydropower harvester is able to convert flowing kinetic energy into electricity and produce a high current density of 2.99 mA cm-2 at a low resistance of 60 Ω. The magnetoelastic generator is intrinsically waterproof since the magnetic field can penetrate the water molecules. As a demonstration, the device maintained a stable electrical output even in underwater situations after over 7,000 cyclic operations. The generated electricity from hydropower could produce H2 at a rate of 1.93 × 10-3 mL min-1. In conclusion, this work provides a compelling method for self-powered water splitting by using flowing kinetic energy.

Smart Textiles for Healthcare and Sustainability.

At the forefront of the smart textile community, healthcare and sustainability are the two crucial objectives targeted by researchers. The development of such powerful devices has been driven by innovative fabrications of breathable, skin-conformable technologies through the use of functional and programmable materials and device structures. This Perspective focuses on the current smart textiles available in the research field, categorized into personalized healthcare, including diagnostics and therapeutics, and sustainability, including energy harvesting and conservation─personalized thermoregulation. These categories are further broken down into their platform structural technologies and performances. Furthermore, we give a comprehensive overview and highlight a few examples of current studies. Finally, we provide an outlook on these technologies for future researchers to participate. We envision that the next generation of smart textiles will revolutionize wearable technology for healthcare and sustainability.

A Soft Magnetoelastic Generator for Wind-Energy Harvesting.

The current energy crises and imminent danger of global warming severely limit the ability to scale societal development sustainably. As such, there is a pressing need for utilizing renewable, green energy sources, such as wind energy, which is ubiquitously available on Earth. In this work, a fundamentally new wind-energy-harvesting technology is reported, which is based on the giant magnetoelastic effect in a soft composite system, namely, magnetoelastic generators. Its working principle is based on wind-induced mechanical deformation, which alters the magnetic field in a soft system converting the wind energy into electricity via electromagnetic induction from arbitrary directions. The wind-energy-harvesting system features a low internal impedance of 68 Ω, a high current density of 1.17 mA cm-2 , and a power density of 0.82 mW cm-2 under ambient natural wind. The system is capable of sustainably driving small electronics and electrolytically splitting water. The system can generate hydrogen at a rate of 7.5 × 10-2 mL h-1 with a wind speed of 20 m s-1 . Additionally, since magnetic fields can penetrate water molecules, the magnetoelastic generators are intrinsically waterproof and work stably in harsh environments. This work paves a new way for wind-energy harvesting with compelling features, which can contribute largely to the hydrogen economy and the sustainability of human civilization.

Kirigami-Inspired Pressure Sensors for Wearable Dynamic Cardiovascular Monitoring.

Continuously and accurately monitoring pulse-wave signals is critical to prevent and diagnose cardiovascular diseases. However, existing wearable pulse sensors are vulnerable to motion artifacts due to the lack of proper adhesion and conformal interface with human skin during body movement. Here, a highly sensitive and conformal pressure sensor inspired by the kirigami structure is developed to measure the human pulse wave on different body artery sites under various prestressing pressure conditions and even with body movement. COMSOL multiphysical field coupling simulation and experimental testing are used to verify the unique advantages of the kirigami structure. The device shows a superior sensitivity (35.2 mV Pa-1 ) and remarkable stability (>84 000 cycles). Toward practical applications, a wireless cardiovascular monitoring system is developed for wirelessly transmitting the pulse signals to a mobile phone in real-time, which successfully distinguished the pulse waveforms from different participants. The pulse waveforms measured by the kirigami inspired pressure sensor are as accurate as those provided by the commercial medical device. Given the compelling features, the sensor provides an ascendant way for wearable electronics to overcome motion artifacts when monitoring pulse signals, thus representing a solid advancement toward personalized healthcare in the era of the Internet of Things.

Giant Magnetoelastic Effect Enabled Stretchable Sensor for Self-Powered Biomonitoring.

Interfacing with the human body, wearable and implantable bioelectronics are a compelling platform technology for healthcare monitoring and medical therapeutics. However, clinical adoption of these devices is largely shadowed by their weakness in humidity resistance, stretchability, durability, and biocompatibility. In this work, we report a self-powered waterproof biomechanical sensor with stretchability up to 440% using the giant magnetoelastic effect in a soft polymer system. By manipulating the magnetic dipole alignment, the sensor achieved a particularly broad sensing range from 3.5 Pa to 2000 kPa, with a response time of ∼3 ms. To validate the excellent performance of the magnetoelastic sensor in biomonitoring, both ex vivo porcine heart testing and in vivo rat model testing were performed for cardiovascular monitoring and heart disease diagnosis. With the obtained sensing data, we have successfully detected ventricular arrhythmia and ventricular fibrillation in the Sprague-Dawley rat model. Holding a collection of compelling features, including minimal hysteresis, ultrawide sensing range, waterproofness, and biocompatibility, the magnetoelastic sensor represents a unique platform technology for self-powered biomonitoring in both wearable and implantable manners.

Electronic Textiles for Wearable Point-of-Care Systems.

Traditional public health systems are suffering from limited, delayed, and inefficient medical services, especially when confronted with the pandemic and the aging population. Fusing traditional textiles with diagnostic, therapeutic, and protective medical devices can unlock electronic textiles (e-textiles) as point-of-care platform technologies on the human body, continuously monitoring vital signs and implementing round-the-clock treatment protocols in close proximity to the patient. This review comprehensively summarizes the research advances on e-textiles for wearable point-of-care systems. We start with a brief introduction to emphasize the significance of e-textiles in the current healthcare system. Then, we describe textile sensors for diagnosis, textile therapeutic devices for medical treatment, and textile protective devices for prevention, by highlighting their working mechanisms, representative materials, and clinical application scenarios. Afterward, we detail e-textiles' connection technologies as the gateway for real-time data transmission and processing in the context of 5G technologies and Internet of Things. Finally, we provide new insights into the remaining challenges and future directions in the field of e-textiles. Fueled by advances in chemistry and materials science, textile-based diagnostic devices, therapeutic devices, protective medical devices, and communication units are expected to interact synergistically to construct intelligent, wearable point-of-care textile platforms, ultimately illuminating the future of healthcare system in the Internet of Things era.

Wearable respiratory sensors for COVID-19 monitoring.

Since its outbreak in 2019, COVID-19 becomes a pandemic, severely burdening the public healthcare systems and causing an economic burden. Thus, societies around the world are prioritizing a return to normal. However, fighting the recession could rekindle the pandemic owing to the lightning-fast transmission rate of SARS-CoV-2. Furthermore, many of those who are infected remain asymptomatic for several days, leading to the increased possibility of unintended transmission of the virus. Thus, developing rigorous and universal testing technologies to continuously detect COVID-19 for entire populations remains a critical challenge that needs to be overcome. Wearable respiratory sensors can monitor biomechanical signals such as the abnormities in respiratory rate and cough frequency caused by COVID-19, as well as biochemical signals such as viral biomarkers from exhaled breaths. The point-of-care system enabled by advanced respiratory sensors is expected to promote better control of the pandemic by providing an accessible, continuous, widespread, noninvasive, and reliable solution for COVID-19 diagnosis, monitoring, and management.

Soft fibers with magnetoelasticity for wearable electronics.

Magnetoelastic effect characterizes the change of materials' magnetic properties under mechanical deformation, which is conventionally observed in some rigid metals or metal alloys. Here we show magnetoelastic effect can also exist in 1D soft fibers with stronger magnetomechanical coupling than that in traditional rigid counterparts. This effect is explained by a wavy chain model based on the magnetic dipole-dipole interaction and demagnetizing factor. To facilitate practical applications, we further invented a textile magnetoelastic generator (MEG), weaving the 1D soft fibers with conductive yarns to couple the observed magnetoelastic effect with magnetic induction, which paves a new way for biomechanical-to-electrical energy conversion with short-circuit current density of 0.63 mA cm-2, internal impedance of 180 Ω, and intrinsic waterproofness. Textile MEG was demonstrated to convert the arterial pulse into electrical signals with a low detection limit of 0.05 kPa,  even with heavy perspiration or in underwater situations without encapsulations.

Wearable Ultrahigh Current Power Source Based on Giant Magnetoelastic Effect in Soft Elastomer System.

In this study, we present the observation of the giant magnetoelastic effect that occurs in soft elastomer systems without the need of external magnetic fields and possesses a magnetomechanical coupling factor that is four times larger than that of traditional rigid metal-based ferromagnetic materials. To investigate the fundamental scientific principles at play, we built a linear model by using COMSOL Multiphysics, which was consistent with the experimental observations. Next, by combining the giant magnetoelastic effect with electromagnetic induction, we developed a magnetoelastic generator (MEG) for biomechanical energy conversion. The wearable MEG demonstrates an ultrahigh output current of 97.17 mA, a low internal impedance of around ∼40 Ω, and an intrinsic waterproof property. We further leveraged the wearable MEG as an ultrahigh current power source to drive a Joule-heating textile for personalized thermoregulation, which increased the temperature of the fiber-shaped resistor by 0.2 °C. The development of the wearable MEG will act as an alternative and compelling approach for on-body electricity generation and arouse a wide range of possibilities in the renewable energy community.

Triboelectric Nanogenerators for Therapeutic Electrical Stimulation.

Current solutions developed for the purpose of in and on body (IOB) electrical stimulation (ES) lack autonomous qualities necessary for comfortable, practical, and self-dependent use. Consequently, recent focus has been placed on developing self-powered IOB therapeutic devices capable of generating therapeutic ES for human use. With the recent invention of the triboelectric nanogenerator (TENG), harnessing passive human biomechanical energy to develop self-powered systems has allowed for the introduction of novel therapeutic ES solutions. TENGs are especially effective at providing ES for IOB therapeutic systems given their bioconformability, low cost, simple manufacturability, and self-powering capabilities. Due to the key role of naturally induced electrical signals in many physiological functions, TENG-induced ES holds promise to provide a novel paradigm in therapeutic interventions. The aim here is to detail research on IOB TENG devices applied for ES-based therapy in the fields of regenerative medicine, neurology, rehabilitation, and pharmaceutical engineering. Furthermore, considering TENG-produced ES can be measured for sensing applications, this technology is paving the way to provide a fully autonomous personalized healthcare system, capable of IOB energy generation, sensing, and therapeutic intervention. Considering these grounds, it seems highly relevant to review TENG-ES research and applications, as they could constitute the foundation and future of personalized healthcare.

Discovering giant magnetoelasticity in soft matter for electronic textiles.

We discovered a giant magnetoelasticity in soft matter with up to 5-fold enhancement of magnetomechanical coupling factors compared to that of rigid metal alloys without an externally applied magnetic field. A wavy chain analytical model based on the magnetic dipole-dipole interaction and demagnetizing field was established, fitting well to the experimental observation. To explore its potentials in electronic textiles, we coupled it with magnetic induction to invent a textile magnetoelastic generator (MEG), a new working mechanism for biomechanical energy conversion, featuring an intrinsic waterproofness, an ultralow internal impedance of approximately 20 Ω, and a high short-circuit current density of 1.37 mA/cm2, which is about four orders of magnitude higher than that of other textile generator counterparts. Meanwhile, assisted by machine learning, the textile MEG could continuously monitor the respiratory activities on heavily perspiring skin without any encapsulation, allowing a timely diagnosis of the respiration abnormalities in a self-powered manner. We foresee that this discovery can be extended to wide-range soft-matter systems, emerging as a compelling approach to develop electronic textiles for energy, sensing, and therapeutic applications.

Advances in 4D-printed physiological monitoring sensors.

Physiological monitoring sensors have been critical in diagnosing and improving the healthcare industry over the past 30 years, despite various limitations regarding providing differences in signal outputs in response to the changes in the user's body. Four-dimensional (4D) printing has been established in less than a decade; therefore, it currently offers limited resources and knowledge. Still, the technique paves the way for novel platforms in today's ever-growing technologies. This innovative paradigm of 4D printing physiological monitoring sensors aspires to provide real-time and continuous diagnoses. In this perspective, we cover the advancements currently available in the 4D printing industry that has arisen in the last septennium, focusing on the overview of 4D printing, its history, and both wearable and implantable physiological sensing solutions. Finally, we explore the current challenges faced in this field, translational research, and its future prospects. All of these aims highlight key areas of attention that can be applied by future researchers to fully transform 4D printed physiological monitoring sensors into more viable medical products.

Advances in triboelectric nanogenerators for biomedical sensing.

Biomedical sensors have been essential in improving healthcare outcomes over the past 30 years, though limited power source access and user wearability restraints have prevented them from taking a constant and active biomedical sensing role in our daily lives. Triboelectric nanogenerators (TENGs) have demonstrated exceptional capabilities and versatility in delivering self-powered and wear-optimized biomedical sensors, and are paving the way for a novel platform technology able to fully integrate into the developing 5G/Internet-of-Things ecosystem. This novel paradigm of TENG-based biomedical sensors aspires to provide ubiquitous and omnipresent real-time biomedical sensing for us all. In this review, we cover the remarkable developments in TENG-based biomedical sensing which have arisen in the last octennium, focusing on both in-body and on-body biomedical sensing solutions. We begin by covering TENG as biomedical sensors in the most relevant, mortality-associated clinical fields of pneumology and cardiology, as well as other organ-related biomedical sensing abilities including ambulation. We also include an overview of ambient biomedical sensing as a field of growing interest in occupational health monitoring. Finally, we explore TENGs as power sources for third party biomedical sensors in a number of fields, and conclude our review by focusing on the future perspectives of TENG biomedical sensors, highlighting key areas of attention to fully translate TENG-based biomedical sensors into clinically and commercially viable digital and wireless consumer and health products.

Smart Insole for Robust Wearable Biomechanical Energy Harvesting in Harsh Environments.

Footfall contains the highest harvestable biomechanical energy from the human body, which can attain 67 W, showing great potential as a pervasive and sustainable power source for wearable bioelectronics in the era of the Internet of Things. Developing an effective technology for robust and efficient energy harvesting from human walking remains highly desired. Here, we present a waterproof smart insole, based on a triboelectric nanogenerator, for highly efficient and robust human biomechanical energy harvesting. This insole was rationally designed as a composite structure to fully utilize the pressure distribution of a footfall for wearable electricity generation and to deliver a power output reaching 580 µW. The insole was additionally able to withstand use in harsh environments, including pluvial conditions, without affecting the power output consistency. A total of 260 light-emitting diodes were lit up with perspiring feet and water on the floor, and a capacitor of 88 µF was charged to 2.5 V in 900 s. This work represents a practical approach to developing a highly efficient and robust smart insole that can be used as a sustainable power source for wearable bioelectronics.

Microfluidic Point-of-Care Ecarin-Based Clotting and Chromogenic Assays for Monitoring Direct Thrombin Inhibitors.

Direct thrombin inhibitors (DTIs), such as bivalirudin and dabigatran, have maintained steady inpatient and outpatient use as substitutes for heparin and warfarin, respectively, because of their high bioavailability and relatively safe "on-therapy" range. Current clinical methods lack the capacity to directly quantify plasma DTI concentrations across wide ranges. At present, the gold standard is the ecarin clotting time (ECT), where ecarin maximizes thrombin activity and clotting time is evaluated to assess DTIs' anticoagulation capability. This work focused on the development of a microfluidic paper analytic device (µPAD) that can quantify the extent of anticoagulation as well as DTI concentration within a patient's whole blood sample. Capillary action propels a small blood sample to flow through the nitrocellulose paper channels. Digital images of whole blood migration are then captured by our self-coded Raspberry Pi and/or the Samsung Galaxy S8 smartphone camera. Both the flow length and the blue absorbance from the plasma front on the µPAD were measured, allowing simultaneous, dual assays: ecarin clotting test (ECT) and ecarin chromogenic assay (ECA). Statistically significant (p < .05) changes in flow and absorbance were observed within our translational research study. Currently, there are no quantitative, commercially available point-of-care tests for the ECT and ECA within the United States. Both the ECT and ECA assays could be instrumental to differentiate between supratherapeutic and subtherapeutic incidents during bridging anticoagulant therapy and limit the unwarranted use of reversal agents.