Search | VHL Regional Portal

Show: 20 | 50 | 100

Results 1 - 1 de 1

Filter

Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands.

Blackaby, Wesley P; Atack, John R; Bromidge, Frances; Castro, José L; Goodacre, Simon C; Hallett, David J; Lewis, Richard T; Marshall, George R; Pike, Andrew; Smith, Alison J; Street, Leslie J; Tattersall, David F D; Wafford, Keith A.

Bioorg Med Chem Lett ; 16(5): 1175-9, 2006 Mar 01.

Article in English | MEDLINE | ID: mdl-16406613

ABSTRACT

Imidazo[1,2-a]pyrimidines are GABA(A) receptor benzodiazepine binding site ligands which can exhibit functional selectivity for the alpha(3) subtype over the alpha(1) subtype. SAR studies to optimize this functional selectivity are described.

Subject(s)

Imidazoles/chemistry , Imidazoles/metabolism , Pyrimidines/chemistry , Pyrimidines/metabolism , Receptors, GABA-A/metabolism , Ligands , Molecular Structure , Pyrimidines/chemical synthesis , Sensitivity and Specificity , Structure-Activity Relationship , Substrate Specificity

ABSTRACT

Subject(s)

SEND TO:

SELECTION OF CITATIONS

SEARCH DETAIL