ABSTRACT
A "transient" precocious puberty with ovarian follicular cysts was observed in four girls. Each girl presented with several successive and transient episodes of development of secondary sex characters: breast development, areolar pigmentation, brown abdominal median line were the clinical signs of oestrogen secretion. At the time of referral, plasma and urinary gonadotropins levels were low in the prepubertal range while plasma oestradiol concentrations were elevated, in the pubertal range. At this time, as well as during each episode of "pubertal" development, the gonadotropins response to GnRH stimulation was blunted. In contrast, a prepubertal or pubertal response was observed when the clinical symptoms of estrogenization had resumed. Ultrasonography showed one or several ovarian follicular cysts. In two cases, the treatment with the GnRH agonist, D-TRP 6 GnRH [Decapeptyl (R)], was successful, suggesting a central dysfunction
Subject(s)
Ovarian Cysts/complications , Ovarian Follicle , Puberty, Precocious/etiology , Child , Child, Preschool , Cyproterone/therapeutic use , Estradiol/blood , Female , Gonadotropin-Releasing Hormone/analogs & derivatives , Gonadotropin-Releasing Hormone/therapeutic use , Gonadotropins/analysis , Humans , Ovarian Cysts/therapy , Pituitary Hormone-Releasing Hormones , Remission, Spontaneous , Triptorelin PamoateABSTRACT
We have been studying a population of 95 normal children aged 10 days to 2 years, in order to determine the normal values of free thyroid hormone in this class of age. The concentrations were measured by radioimmunoassay (Lepetit system). Free T3 (FT3) appears remarkably stable, with a mean at 4,92 pg/ml (3,23 - 7,50 mg/ml at +/- 2SD). These concentrations are significantly higher than those of adult. Free T4 (FT4) shows a significant decrease over the first month of life, with a mean at 14,31 pg/ml (10,27 - 19,94 pg/ml at +/- 2SD). There is no significant variation between the age of one month and 2 years. The mean is 10,51 pg/ml (7,00 - 15,79 pg/ml +/- 2SD).
