ABSTRACT
Patients with moderate to severe acne vulgaris were treated for 10 weeks with either topical clindamycin phosphate (1% solution) twice daily, benzoyl peroxide (5% gel) twice daily, or benzoyl peroxide (5% gel) in the morning and clindamycin phosphate (1% solution) in the evening. The effects of each regimen appeared to vary in decreasing specific types of acne lesions, with the combination therapy showing the greatest decrease when all types of lesions were considered. Cutaneous side-effects were greatest with benzoyl peroxide alone during the early weeks of treatment, while the combination therapy displayed no greater incidence of redness, scaling, or itching than clindamycin phosphate alone. All three regimens produced clinical improvements which did not differ significantly from each other.
Subject(s)
Acne Vulgaris/drug therapy , Benzoyl Peroxide/therapeutic use , Clindamycin/analogs & derivatives , Peroxides/therapeutic use , Adolescent , Adult , Benzoyl Peroxide/administration & dosage , Child , Clindamycin/administration & dosage , Clindamycin/therapeutic use , Drug Therapy, Combination , Female , Humans , MaleABSTRACT
Lichen aureus is an infrequently reported subset of the pigmented purpuric dermatoses. A review of the English literature suggests the golden to purple colored lesions are asymptomatic or mildly pruritic with no regression once established. A case report of a 56-year-old man with lichen aureus of the thighs is presented. This case is unusual in that the patient had persistent pain at the lesion site. Furthermore, increased capillary fragility and koebnerization were both demonstrated. Treatment of an asymptomatic urinary tract infection resulted in temporary subjective and objective improvement.
