Influence of the use of bisphosphonates on the development of postextraction sequelae: scoping review with mapping evidence of in vivo studies.

OBJECTIVE: To map the current scientific landscape regarding the association/causality of medication-related osteonecrosis of the jaw (MRONJ) after tooth extraction under bisphosphonate (BF) therapy to identify knowledge gaps and guide future research. DATA: This review used the PCC strategy (P = Patient; C = Concept; C = Context). SOURCES: The MEDLINE/PubMed, Scopus, Web of Science/Clarivate Analytics, and gray literature databases were used. STUDY SELECTION: Searches were conducted by two independent reviewers until April 2024. Studies involving prior BF use and tooth extraction in humans or animals were included. Among the 176 studies, 73 (41.4%) were in animals, and 103 (58.5%) were in humans. Brazil led in animal studies (n=14; 19.1%), while Italy led in human studies (n=14; 13.6%). Zoledronic acid was the most cited BF (79.4% in animals; 34.9% in humans), with intravenous administration being most frequent (38.3% in animals; 35.9% in humans). The mandible was the main extraction site (n=36 in animals; n=41 in humans). In 91.7% of the animal studies, sequelae compatible with osteonecrosis signs and symptoms were observed, with bone necrosis being most common (n=39; 53.4%). In humans, 93.2% of studies presented 239 sequelae, with bone necrosis (n=53; 22.1%) being the most cited. The main location of sequelae was the mandible (n=36 in animals; n=41 in humans). CONCLUSIONS: Animal studies highlighted bone exposure, notably using murine models, with a significant Brazilian contribution. In human studies, bone necrosis was the main sequela of MRONJ, which has been reported by researchers in the Italy. CLINICAL SIGNIFICANCE: These findings underscore the importance of careful consideration and monitoring of patients who have a history of bisphosphonate use and who are undergoing tooth extraction, highlighting the potential risk of MRONJ.

Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients.

BACKGROUND: Hemodialysis (HD) per se is a risk factor for thrombosis. Considering the growing body of evidence on blood-flow restriction (BFR) exercise in HD patients, identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training model. The aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise (RE) with BFR on this molecule. METHODS: Two hundred and six HD patients volunteered for this study (all with a glomerular filtration rate of <15 mL/min/1.73 m2). The RE + BFR session consisted of 50% arterial occlusion pressure during 50 min sessions of HD (intradialytic exercise). RE repetitions included concentric and eccentric lifting phases (each lasting 2 s) and were supervised by a strength and conditioning specialist. RESULTS: Several variables were associated with elevated levels of D-dimer, including higher blood glucose, citrate use, recent cardiovascular events, recent intercurrents, higher inflammatory status, catheter as vascular access, older patients (>70 years old), and HD vintage. Furthermore, RE + BFR significantly increases D-dimer after 4 h. Patients with borderline baseline D-dimer levels (400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range (≥500 ng/mL). CONCLUSION: These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE + BFR. D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE + BFR.

Exploring the impact of short daily haemodialysis on muscle strength and bone health in end-stage kidney disease patients.

BACKGROUND: Short-daily haemodialysis (SDH) has been strongly recommended over conventional haemodialysis (CHD) for end-stage kidney disease patients, though few studies have directly compared the effects of these two haemodialysis (HD) modalities on clinical variables related to patient's health. METHODS: We conducted a cross-sectional study in individuals undergoing HD, comparing epidemiological, clinical, metabolic, inflammatory, anthropometric, bone health/metabolism, and skeletal muscle function according to dialysis modality. One-hundred seventy-eight patients (20.8% females, 62 ± 2.5 years old), were analysed in this study, 86 (48%) of whom were undergoing CHD versus 92 (51%) who were undergoing SDH. RESULTS: SDH patients had significantly higher serum albumin levels (3.93 vs. 3.66 g/dL, P < 0.0001) and higher Kt/v (2.6 vs. 2.38, P < 0.0001). SDH group presented a significantly lower number of erythropoietin-stimulating agents compared with CHD group (percentage: 53.3 vs. 83.7%, P < 0.0001) and had lower levels of serum phosphate (4.9 vs. 5.3 mg/dL, P = 0.004) and parathyroid hormone (PTH) (398.4 vs. 480.4 pg/mL, P < 0.001) compared with CHD patients. In terms of bone health and metabolism, SDH patients had significantly higher total BMD, femur BMD, lumbar BMD, and femoral neck BMD compared with CHD patients (all P < 0.05). SDH patients also had lower anti-osteogenic and inflammatory biomarkers, including FGF23, sclerostin, TNF, IL-18, IL-17a, and C-reactive peptide (all P < 0.05). CHD modality was demonstrated to be a risk factor for low BMD (odds ratio: 4.02; 95% CI: 1.59-10.2, P = 0.003). In terms of skeletal muscle function, SDH patients had significantly higher 6-minute walking test (444.6 vs. 424.9 m, P = 0.04) and higher fat-free mass (52.3 vs. 51.68 kg, P = 0.02) compared with CHD patients. Higher fat-free mass and handgrip strength were associated with a 34% and 23% lower risk of low BMD, respectively. SDH patients had lower levels of the uremic toxin asymmetric dimethyl-l-arginine (ADMA) (1.8 vs. 2.07 µM, P = 0.002) and fasting blood glucose (132.6 vs. 141.7 mg/dL, P < 0.02) than CHD group. SDH patients also displayed higher levels of haemoglobin when compared with CHD group (11.9 vs. 10.2 g/dL, P < 0.0001). CONCLUSIONS: The present study improves our understanding of the relationship between dialysis modality and clinical variables that may influence HD patient's health. Grip strength and lean mass were positively correlated with bone mineral density in HD patients regardless of dialysis modality. SDH was associated with better bone mineral density, inflammatory profile, and skeletal muscle function when compared with CHD patients. These findings provide more evidence of the clinical benefits of SDH that should be explored in greater detail.

In vitro and in situ caries-preventive effect of a new combined fluoride and calcium experimental nanocomposite solution.

To assess the in vitro and in situ effect of experimental combined fluoride and calcium nanocomposite solutions on dental caries prevention. Nanocompound mesoporous silica (MS) with calcium (Ca) and sodium fluoride (NaF) - (MSCaNaF); MS with NaF (MSNaF), NaF solution (positive control), and deionized water (negative control - CG) were studied. The specimens (n=130) were submitted in vitro to a multispecies biofilm in the presence of 2% sucrose. After 24 h and 48 h, the culture medium pH, the percent of surface mineral loss (%SML), and lesion depth (ΔZ) were analyzed. In the in situ study, 10 volunteers participated in four phases of 7-days each. The products were applied on the specimens (n=240) before 20% sucrose solution drips. The polysaccharides (SEPS and IEPS), %SML and roughness (Sa) were evaluated. There was an in vitro decrease in pH values in 24h and 48h, compared to baseline. The MSCaNaF and MSNaF groups obtained lower values of %SML and ΔZ (p < 0.05) than CG and NaF after 24h and were similar to NaF after 48h (p<0.05). In situ results showed similar SEPS and IEPS among all groups after 48h. An after 7-days, the nanocomposites had similar values (p>0.05), while NaF was similar to CG (p>0.05). After 48h, the MSCaNaF and MSNaF reduced the %SML (p<0.05). After 7-days, both experimental nanocomposites were similar to NaF (p>0.05). Regarding Sa, MSCaNaF was better than NaF for both periods (p<0.05). The nanocomposites controlled the in vitro and in situ enamel demineralization, mainly in the initial periods.

In vitro and in situ caries-preventive effect of a new combined fluoride and calcium experimental nanocomposite solution

Abstract To assess the in vitro and in situ effect of experimental combined fluoride and calcium nanocomposite solutions on dental caries prevention. Nanocompound mesoporous silica (MS) with calcium (Ca) and sodium fluoride (NaF) - (MSCaNaF); MS with NaF (MSNaF), NaF solution (positive control), and deionized water (negative control - CG) were studied. The specimens (n=130) were submitted in vitro to a multispecies biofilm in the presence of 2% sucrose. After 24 h and 48 h, the culture medium pH, the percent of surface mineral loss (%SML), and lesion depth (ΔZ) were analyzed. In the in situ study, 10 volunteers participated in four phases of 7-days each. The products were applied on the specimens (n=240) before 20% sucrose solution drips. The polysaccharides (SEPS and IEPS), %SML and roughness (Sa) were evaluated. There was an in vitro decrease in pH values in 24h and 48h, compared to baseline. The MSCaNaF and MSNaF groups obtained lower values of %SML and ΔZ (p < 0.05) than CG and NaF after 24h and were similar to NaF after 48h (p<0.05). In situ results showed similar SEPS and IEPS among all groups after 48h. An after 7-days, the nanocomposites had similar values (p>0.05), while NaF was similar to CG (p>0.05). After 48h, the MSCaNaF and MSNaF reduced the %SML (p<0.05). After 7-days, both experimental nanocomposites were similar to NaF (p>0.05). Regarding Sa, MSCaNaF was better than NaF for both periods (p<0.05). The nanocomposites controlled the in vitro and in situ enamel demineralization, mainly in the initial periods.

Could sarcopenia-related mortality in end-stage renal disease be underpinned by the number of hospitalizations and cardiovascular diseases?

PURPOSE: To investigate the association between sarcopenia with the number of all-cause mortality, hospitalizations, and cardiovascular diseases in patients with end-stage renal disease (ESRD). METHODS: 247 patients with ESRD (women, n = 97) (66.6 ± 3.53 years) participated in this study. At baseline, all participants were measured with dual-energy X-ray absorptiometry and handgrip dynamometer and were prospectively followed up for 5 years. The European Working Group on Sarcopenia in Older People guidelines were utilized for Sarcopenia determination. Cox proportional hazard analysis adjusted for established risk factors was used to quantify the risk between Sarcopenia and all-cause mortality. RESULTS: Sixty-five participants (26%) were determined to have Sarcopenia at baseline and 38 (15%) have died during the follow-up. At baseline, Participants with Sarcopenia had lower body mass index and fat-free mass index. Moreover, through the 5-year follow-up, sarcopenic patients had higher number of cardiovascular disease (56.9% vs. 12.6%) and hospitalizations (93.8% vs. 49.5%) (all P < 0.0001). Sarcopenia was associated with significantly higher risk of mortality, [Hazard ratio = 3.3, (95% CI: 1.6-6.9), P = 0.001]. CONCLUSION: Sarcopenia may be a risk factor for hospitalizations, cardiovascular diseases, and all-cause mortality in patients with ESRD. These results provide support of the relevance in assessing sarcopenia in the clinical practice of chronic kidney disease and how muscle mass and strength may negatively impact the daily life of ESRD patients undergoing hemodialysis. Greater efforts at preventing muscle wasting and malfunctioning are needed through the worldwide healthcare system.

Birth-related and current factors associated with physical inactivity in the leisure time in Brazilian adolescents.

BACKGROUND: To determine whether biological and sociodemographic factors at birth and current factors are associated with insufficient physical activity during leisure among Brazilian adolescents. METHODS: A school-based cross-sectional study with national coverage was conducted involving Brazilian adolescents 12 to 17 years of age in municipalities with more than 100 thousand residents. The sample consisted of 74,589 adolescents who participated in the Study of Cardiovascular Risk in Adolescents. Insufficient leisure-time physical activity was categorized based on total volume (<300 minutes/week = insufficiently active; >300 minutes/week = sufficiently active). Poisson regression models were used to assess associated factors. RESULTS: Most adolescents were classified as insufficiently active (54.8%; 95%CI: 53.7-55.9). The variables associated with insufficient physical activity during leisure were the female sex (70.4%; 95%CI: 68.8-71.9), age between 15 and 17 years (57.8%; 95%CI: 56.3-59.2), pertaining to the low or middle class (54.5%; 95%CI: 52.8-56.1), and not being overweight (55.9%; 95%CI: 54.6-57.1). CONCLUSION: Contrary to our hypothesis, birth related factors (e.g., low birth weight, preterm birth and exclusive breastfeeding until 6 months of age) are not associated with physical inactivity. The prevalence of insufficient physical activity during leisure was high among the adolescents evaluated and was associated with sociodemographic characteristics as well as nutritional status. It is necessary to implement strategies focused on physical activity at schools.

40 anos do Simpósio Nacional de Educação Física: revisitando um espaço de produção do conhecimento / 40 years of the National Symposium on Physical Education: revisiting a space to produce knowledge / 40 años del Simposio Nacional de Educación Física: revisitando un espacio de producción de conocimiento

O texto objetivou resgatar as memórias do Simpósio Nacional de Educação Física a partir dos trabalhos apresentados no evento. Realizou-se uma análise documental dos anais das edições de 1980 a 2021, a partir de: a) análise dos títulos, palavras-chave e resumos; b) análise do trabalho na íntegra, verificando a abordagem do conteúdo e categorização final a partir das áreas temáticas de conhecimento (ATC) estabelecidas. Cada resumo passou pela análise de dois pesquisadores adotando critérios de elegibilidade. O mapeamento das ATC foi baseado em temáticas delimitadas nos grupos temáticos do Colégio Brasileiro de Ciências do Esporte. Assim foram elencadas seis ATC: Atividade motora, Saúde e desempenho; Escola; Currículo e formação docente; Lazer e políticas públicas; Memória, esporte e cultura; Inclusão e deficiência. A ESEF-UFPel alcançou um patamar diferenciado, no ensino de graduação e Pós-Graduação e a pluralidade de formação dos docentes, contribuiu significativamente para ser uma referência no cenário nacional.

The text aimed to rescue the memories of the National Symposium of Physical Education from the works presented at the event. A documentary analysis of the annals of the editions from 1980 to 2021 was carried out, based on: a) analysis of titles, keywords, and abstracts; b) analysis of the work in its entirety, verifying the content approach and final categorization from the established thematic areas of knowledge (TAK). Each abstract was analyzed by two researchers adopting eligibility criteria. The mapping of the TAK was based on themes delimited in the thematic groups of the Brazilian College of Sports Sciences. Thus, six TAK were listed: Motor activity, Health, and performance; School; Curriculum and teacher training; Leisure and public policies; Memory, sport, and culture; Inclusion and Disability. The ESEF-UFPel has reached a differentiated level in undergraduate and graduate education and the plurality of teacher training has significantly contributed to being a reference on the national scene.

El texto tuvo como objetivo rescatar las memorias del Simposio Nacional de Educación Física a partir de los trabajos presentados en el evento. Se realizó un análisis documental de los anales de las ediciones de 1980 a 2021, a partir de: a) análisis de títulos, palabras clave y resúmenes; b) análisis del trabajo en su totalidad, verificando el enfoque de contenido y categorización final a partir de las áreas temáticas de conocimiento (ATC) establecidas. Cada resumen fue analizado por dos investigadores que adoptaron criterios de elegibilidad. El mapeo de ATC se basó en temas definidos en los grupos temáticos de la Facultad Brasileña de Ciencias del Deporte. Así, se enumeraron seis ATC: Actividad motora, Salud y rendimiento; Colegio; Currículo y formación docente; Ocio y políticas públicas; Memoria, deporte y cultura; Inclusión y Discapacidad. La ESEF-UFPel ha alcanzado un nivel diferenciado en la formación de grado y posgrado y la pluralidad de la formación docente ha contribuido significativamente a ser una referencia en el escenario nacional.

Virtual Screening and Molecular Docking: Discovering Novel c-KIT Inhibitors.

Gastrointestinal stromal tumors (GISTs) are unusual cancers, which are developed in specialized cells in the gastrointestinal tract wall. Various strategies involving single-agents, combinations, and rapid complementary inhibitor cycling are now being used to control such tumors. Based on promising early clinical trial experience, certain novel KIT and PDGFRA tyrosine kinase inhibitors have shown advanced clinical development. Resistance to tyrosine kinase inhibitors has brought immense difficulties, with patients now requiring additional therapeutic options. This review describes and discusses the last five years (2016-2020) in developing novel c-KIT kinase inhibitors using virtual screening and docking approaches. Computational techniques can be used to complement experimental studies to identify new candidate molecules for therapeutic use. Molecular modeling strategies allow the analysis of the required characteristics that compounds must have to effectively bind c-KIT. Through such analyses, it is possible to both discover and design novel inhibitors against cancer-related proteins that play a critical role in tumor development (including mutant strains). Docking showed potential in the detection of the key residues responsible for ligand recognition and is very helpful to understand the interactions in the active site that can be used to develop new compounds/classes of anticancer drugs and help millions of cancer patients.

Situação de insegurança alimentar em domicílios de Pernambuco, Região Nordeste do Brasil: contribuições para discussão da violação do direito à alimentação / Food insecurity in households in Pernambuco, Northeast region of Brazil: contributions to the discussion on the violation of the right to adequate food

Resumo O objetivo deste estudo foi investigar os fatores associados à insegurança alimentar em domicílios do Estado de Pernambuco, localizado na região Nordeste do Brasil. Trata-se de um estudo transversal realizado em 1.008 domicílios particulares. Para a investigação, utilizou-se a Escala Brasileira de Insegurança Alimentar (EBIA) e foram analisadas associações com variáveis socioeconômicas, demográficas e práticas relacionadas à alimentação. Calculou-se razão de prevalência e ajuste por meio da regressão de Poisson, sendo estatisticamente significantes aquelas associações cujo p≤0,05. Encontrou-se prevalência de 68,4% de insegurança alimentar. Apresentaram associação com insegurança: escolaridade do chefe da família; renda per capita; participação no programa Bolsa Família; número de moradores; regime de ocupação do domicílio; classe social; práticas; e opiniões acerca da alimentação da família. O maior risco de insegurança foi encontrado naqueles com pior condição econômica, em beneficiários do Bolsa Família e naqueles que indicavam a falta de produtos ultraprocessados para melhorar a alimentação da família. Observou-se insegurança alimentar atrelada às condições de vulnerabilidade social e àqueles que não consideravam ter uma boa alimentação. Grande parte dos sujeitos referiram utilizar os recursos do Bolsa Família para aquisição de alimentos, o que reforça a importância dessa estratégia na promoção do acesso à alimentação.

Abstract This study aimed to investigate factors associated with food insecurity in households in the state of Pernambuco, in the Northeast region of Brazil. This is a cross-sectional study carried out in 1,008 private households. The investigation used the Brazilian Food Insecurity Scale (EBIA) and analyzed associations with socioeconomic and demographic variables, as well as practices related to eating. Prevalence ratio and adjustment were calculated using Poisson regression, and associations where p ≤ 0.05 were statistically significant. Food insecurity prevalence was 68.4%. Variables associated with insecurity were: education of the head of the family; per capita income; participation in the Bolsa Família Program; number of residents; occupation of the household; social class; practices and opinions about family eating habits. The greatest insecurity risk was found in those with the worst economic conditions, in beneficiaries of the Bolsa Família Program and in those who considered the lack of ultra-processed products to improve the family's diet. Food insecurity was linked to conditions of social vulnerability and to those who did not perceive that they had a good diet. Most of the subjects reported using resources of the Bolsa Família program to purchase food, which reinforces the importance of this strategy in promoting access to food.

[Perception of body weight above the ideal, anthropometric profile and lifestyle among adolescents in the city of Recife, Brazil]. / Percepção do peso corporal acima do ideal, perfil antropométrico e estilo de vida em adolescentes de Recife, PE, Brasil.

This study investigated the perception of above ideal body weight among adolescents in the city of Recife, Brazil, and its association with anthropometric profile and lifestyle. A cross-sectional study was conducted with a sample of 2480 adolescents from the "Study of Cardiovascular Risks in Adolescents." The conceptual model also assessed demographic and socioeconomic variables. Body weight perception was analyzed by asking the question: "In your opinion, your current body weight is … ?" Answers included: below ideal, ideal and above ideal body weight. Statistics were identified using Poisson Regression analysis. The mean age was 14.7 years (SD = 1.6), 53.7% were female, and 70.7% were eutrophic according to the body mass index/age (BMI/A). Perception of body weight was answered by 48.8% of the adolescents. 36.8% and 63.2% saw themselves as below and above their ideal weight, respectively. After adjustments, the variables associated with the perception of body weight above the ideal (outcome variable) were the female sex, age 12 to 14 years, mother's schooling > 8 years, BMI/A in the ideal range, being postpubescent, having breakfast and meals with parents occasionally. Demographic, anthropometric and lifestyle variables were more likely to be associated with body weight perception above the ideal.

O objetivo da pesquisa foi analisar a percepção do peso corporal acima do ideal em adolescentes de Recife/PE e sua associação com o perfil antropométrico e estilo de vida. Trata-se de um estudo transversal com 2.480 escolares participantes do Estudo de Riscos Cardiovasculares em Adolescentes (Erica). O modelo conceitual também considerou variáveis demográficas e socioeconômicas. A percepção do peso foi analisada por meio da pergunta "Na sua opinião o seu peso atual é?", sendo as respostas: "abaixo do ideal", "ideal" e "acima do ideal". As associações foram identificadas por meio da regressão de Poisson. A média da idade foi de 14,7 anos (DP = 1,6), 53,7% eram do sexo feminino e 70,7% eram eutróficos, de acordo com o índice de massa corporal/idade (IMC/I). A percepção do peso foi respondida por 48,8% dos adolescentes. Desses, 36,8% e 63,2% se percebiam com baixo peso e peso acima do ideal, respectivamente. Após os ajustes, as variáveis associadas à percepção do peso acima do ideal foram: sexo feminino, idade entre 12 e 14 anos, escolaridade materna maior que oito anos, IMC/I de eutrofia e de excesso de peso, estágio pós-púbere e realização de café da manhã e refeição com os pais ocasionalmente. Portanto, variáveis demográficas, antropométricas e do estilo de vida se associaram à maior chance de percepção do peso corporal acima do ideal.

Percepção do peso corporal acima do ideal, perfil antropométrico e estilo de vida em adolescentes de Recife, PE, Brasil / Perception of body weight above the ideal, anthropometric profile and lifestyle among adolescents in the city of Recife, Brazil

Resumo O objetivo da pesquisa foi analisar a percepção do peso corporal acima do ideal em adolescentes de Recife/PE e sua associação com o perfil antropométrico e estilo de vida. Trata-se de um estudo transversal com 2.480 escolares participantes do Estudo de Riscos Cardiovasculares em Adolescentes (Erica). O modelo conceitual também considerou variáveis demográficas e socioeconômicas. A percepção do peso foi analisada por meio da pergunta "Na sua opinião o seu peso atual é?", sendo as respostas: "abaixo do ideal", "ideal" e "acima do ideal". As associações foram identificadas por meio da regressão de Poisson. A média da idade foi de 14,7 anos (DP = 1,6), 53,7% eram do sexo feminino e 70,7% eram eutróficos, de acordo com o índice de massa corporal/idade (IMC/I). A percepção do peso foi respondida por 48,8% dos adolescentes. Desses, 36,8% e 63,2% se percebiam com baixo peso e peso acima do ideal, respectivamente. Após os ajustes, as variáveis associadas à percepção do peso acima do ideal foram: sexo feminino, idade entre 12 e 14 anos, escolaridade materna maior que oito anos, IMC/I de eutrofia e de excesso de peso, estágio pós-púbere e realização de café da manhã e refeição com os pais ocasionalmente. Portanto, variáveis demográficas, antropométricas e do estilo de vida se associaram à maior chance de percepção do peso corporal acima do ideal.

Abstract This study investigated the perception of above ideal body weight among adolescents in the city of Recife, Brazil, and its association with anthropometric profile and lifestyle. A cross-sectional study was conducted with a sample of 2480 adolescents from the "Study of Cardiovascular Risks in Adolescents." The conceptual model also assessed demographic and socioeconomic variables. Body weight perception was analyzed by asking the question: "In your opinion, your current body weight is … ?" Answers included: below ideal, ideal and above ideal body weight. Statistics were identified using Poisson Regression analysis. The mean age was 14.7 years (SD = 1.6), 53.7% were female, and 70.7% were eutrophic according to the body mass index/age (BMI/A). Perception of body weight was answered by 48.8% of the adolescents. 36.8% and 63.2% saw themselves as below and above their ideal weight, respectively. After adjustments, the variables associated with the perception of body weight above the ideal (outcome variable) were the female sex, age 12 to 14 years, mother's schooling > 8 years, BMI/A in the ideal range, being postpubescent, having breakfast and meals with parents occasionally. Demographic, anthropometric and lifestyle variables were more likely to be associated with body weight perception above the ideal.

Does the Combined Effect of Resistance Training with EPO and Iron Sulfate Improve Iron Metabolism in Older Individuals with End-Stage Renal Disease?

We sought to investigate the effects of resistance training (RT) combined with erythropoietin (EPO) and iron sulfate on the hemoglobin, hepcidin, ferritin, iron status, and inflammatory profile in older individuals with end-stage renal disease (ESRD). ESRD patients (n: 157; age: 66.8 ± 3.6; body mass: 73 ± 15; body mass index: 27 ± 3), were assigned to control (CTL; n: 76) and exercise groups (RT; n: 81). The CTL group was divided according to the iron treatment received: without iron treatment (CTL-none; n = 19), treated only with iron sulfate or EPO (CTL-EPO or IRON; n = 19), and treated with both iron sulfate and EPO (CTL-EPO + IRON; n = 76). The RT group followed the same pattern: (RT-none; n = 20), (RT-EPO or IRON; n = 18), and (RT-EPO + IRON; n = 86). RT consisted of 24 weeks/3 days per week at moderate intensity of full-body resistance exercises prior to the hemodialysis section. The RT group, regardless of the iron treatment, improved iron metabolism in older individuals with ESRD. These results provide some clues on the effects of RT and its combination with EPO and iron sulfate in this population, highlighting RT as an important coadjutant in ESRD-iron deficiency.

Biosorption mechanisms of cationic and anionic dyes in a low-cost residue from brewer's spent grain.

The brewer's spent grain (BSG) is a byproduct of the brewing industry produced in large quantities and with few ecological disposal options. The use of this low-cost residue was investigated for the removal of methylene blue (MB) and tartrazine yellow (TY) dyes. The BSG has been extensively characterized to obtain its physicochemical characteristics. Batch experiments were conducted to investigate the effects of biosorption parameters: initial pH, kinetics, equilibrium isotherms and adsorption thermodynamics. The characterization showed high carbon content and heterogeneous morphology with the presence of meso and macropores. The best experimental conditions were obtained as pH 11 for MB and pH 2 for TY. Kinetics resulted in an equilibrium time of 240 min for MB and 300 min for TY and was best represented by the pseudo-second order model. Different interaction mechanisms were suggested, such as electrostatic interactions, electron donors and electron acceptors, hydrogen bonds, π-π dispersion interactions and the dye molecules aggregation. Equilibrium data were better represented by Langmuir isotherm. The maximum adsorbed amount of MB and TY was 284.75 and 26.18 mg/g, respectively, in each better experimental condition. Through the thermodynamic analysis, it was observed that the adsorption of the dyes was spontaneous and favourable. MB is preferentially retained through chemisorption, whereas TY followed a physical process. Considering the characteristics and results found compared to the recent literature, it was verified that BSG can be used as an effective and innovative biosorbent for removal purposes of dyeing effluent.

Alimentação do Trabalhador: uma avaliação em indústrias no nordeste do Brasil / Workers Nutrition: an evaluation in industries in north-eastern Brazil

Resumo Objetivo deste artigo é avaliar o Programa de Alimentação do Trabalhador sob a ótica de gestores, nutricionistas e a alimentação oferecida em indústrias da Região Metropolitana do Recife. Trata-se de um estudo transversal. Foi aplicado questionário estruturado com 40 gestores e 40 nutricionistas acerca dos seus conhecimentos sobre o programa e o cumprimento das atribuições exigidas por ele. Também foi avaliada a qualidade nutricional dos cardápios. Entre os gestores e os nutricionistas, 22,5% e 72,5% não sabiam do cadastro no programa e das suas exigências nutricionais, respectivamente. Grande parte dos nutricionistas e gestores relacionou o programa a uma exigência da legislação trabalhista. Nenhum respondente conhecia a obrigatoriedade de ações de educação alimentar e nutricional, mesmo assim, 55% dos serviços realizavam ações educativas e 25% realiza avaliação nutricional dos trabalhadores. Observou-se que apesar da oferta de bebidas naturais, frutas e folhosos diariamente, também há oferta diária de diversos produtos ultraprocessados, principalmente doces e bebidas artificiais. O estudo evidenciou o pouco conhecimento dos gestores e dos nutricionistas sobre os objetivos do programa bem como a sua insipiente execução.

Abstract The scope of this article is to evaluate the Worker Food Program from the viewpoint of managers, nutritionists and the food offered in industries of the Metropolitan Region of Recife. It consisted of a cross-sectional study. A structured questionnaire was filled out by 40 managers and 40 nutritionists regarding their knowledge about the program and compliance with the tasks required by it. The nutritional quality of the menus was also evaluated. Among the managers and nutritionists, 22.5% and 72.5%, respectively, did not know about the enrolment in the program and the nutritional requirements involved. Most nutritionists and managers related the program to a labor law requirement. None of the respondents knew about the mandatory food and nutritional education actions, even though 55% of the services involved educational actions and 25% performed nutritional assessment of the workers. It was found that, despite the daily supply of natural beverages, fruit and leafy vegetables, there is also a daily supply of various ultra-processed products, especially sweet foods and artificial beverages. The study revealed the lack of knowledge of managers and nutritionists about the objectives of the program as well as its incipient execution.

[Worker's Nutrition: an evaluation in industries in north-eastern Brazil]. / Alimentação do Trabalhador: uma avaliação em indústrias no nordeste do Brasil.

The scope of this article is to evaluate the Worker Food Program from the viewpoint of managers, nutritionists and the food offered in industries of the Metropolitan Region of Recife. It consisted of a cross-sectional study. A structured questionnaire was filled out by 40 managers and 40 nutritionists regarding their knowledge about the program and compliance with the tasks required by it. The nutritional quality of the menus was also evaluated. Among the managers and nutritionists, 22.5% and 72.5%, respectively, did not know about the enrolment in the program and the nutritional requirements involved. Most nutritionists and managers related the program to a labor law requirement. None of the respondents knew about the mandatory food and nutritional education actions, even though 55% of the services involved educational actions and 25% performed nutritional assessment of the workers. It was found that, despite the daily supply of natural beverages, fruit and leafy vegetables, there is also a daily supply of various ultra-processed products, especially sweet foods and artificial beverages. The study revealed the lack of knowledge of managers and nutritionists about the objectives of the program as well as its incipient execution.

Objetivo deste artigo é avaliar o Programa de Alimentação do Trabalhador sob a ótica de gestores, nutricionistas e a alimentação oferecida em indústrias da Região Metropolitana do Recife. Trata-se de um estudo transversal. Foi aplicado questionário estruturado com 40 gestores e 40 nutricionistas acerca dos seus conhecimentos sobre o programa e o cumprimento das atribuições exigidas por ele. Também foi avaliada a qualidade nutricional dos cardápios. Entre os gestores e os nutricionistas, 22,5% e 72,5% não sabiam do cadastro no programa e das suas exigências nutricionais, respectivamente. Grande parte dos nutricionistas e gestores relacionou o programa a uma exigência da legislação trabalhista. Nenhum respondente conhecia a obrigatoriedade de ações de educação alimentar e nutricional, mesmo assim, 55% dos serviços realizavam ações educativas e 25% realiza avaliação nutricional dos trabalhadores. Observou-se que apesar da oferta de bebidas naturais, frutas e folhosos diariamente, também há oferta diária de diversos produtos ultraprocessados, principalmente doces e bebidas artificiais. O estudo evidenciou o pouco conhecimento dos gestores e dos nutricionistas sobre os objetivos do programa bem como a sua insipiente execução.

Padrões alimentares de mulheres em idade reprodutiva: realidade na Zona da Mata nordestina / Eating patterns among women of reproductive age: reality in the Zona Mata, Northeastern Brazil

Objetivo: Verificar os padrões alimentares e os fatores associados de mulheres em idade reprodutiva. Métodos: Trata-se de estudo transversal realizado com 322 mulheres de 12 a 49 anos, residentes em Vitória de Santo Antão, Zona da Mata de Pernambuco, através de busca ativa nos domicílios. Os setores censitários foram sorteados de forma aleatória simples, abrangendo as unidades de saúde pertencentes à Estratégia de Saúde da Família. A partir do Questionário de Frequência Alimentar, identificaram-se os padrões alimentares, categorizados em baixo consumo, 1º e 2º tercil, e alto consumo, tercil superior. As variáveis independentes analisadas foram as sociodemográficas, de estilo de vida e de saúde. Resultados: Do grupo estudado, 59,3% tinham entre 20 e 39 anos e 60,9% apresentavam excesso de peso. Verificaram-se três padrões alimentares: Saudável, Comum Típico Brasileiro e Fast-food. As mulheres com idade ≥ 40 anos consumiam aproximadamente três vezes mais alimentos do padrão Saudável, quando comparadas àquelas com idade ≤ 19 anos. Em contraste, aquelas com idade ≥ 40 anos apresentaram menor probabilidade de consumir alimentos do padrão Fast-food do que as mais jovens (≤ 19 anos). Verificou-se ainda que mulheres com escolaridade superior a oito anos tinham maior probabilidade de consumir alimentos do padrão Fast-food quando comparadas aquelas com ≤ 4 anos de estudo. Conclusões: As mulheres mais jovens e as de maior escolaridade apresentaram um consumo elevado do padrão alimentar Fast-food, em comparação às mais velhas e de menor escolaridade, respectivamente. (AU)

Objective: To analyze eating patterns and associated factors in women of reproductive age. Methods: This is a cross-sectional study conducted with 322 women aged 12 to 49 years old, residing in Vitória de Santo Antão, Pernambuco's Zona da Mata, Brazil, through active household survey. Census sectors were drawn in a simple and random manner, covering the health units belonging to the Family Health Strategy. The Eating Frequency Questionnaire allowed identifying eating patterns, categorized into low consumption, 1st and 2nd terciles, and high consumption, higher tercile. The independent variables analyzed were sociodemographic, lifestyle and health. Results: Within the studied group, 59.3% of the women were aged between 20 and 39 years old, and 60.9% had excessive weight. Three eating patterns were observed: Healthy, Brazilian-Typical Common, and Fast-Food. Women aged ≥ 40 years old consumed approximately three times more food of the Healthy pattern compared to those aged ≤ 19 years old. On the other hand, those aged ≥ 40 were less likely to consume foods of the Fast-Food pattern than the younger ones were (≤ 19 years old). Moreover, women with more than eight years of education were more likely to consume foods of the Fast-Food pattern compared to those with ≤ 4 years of education. Conclusions: Younger and better educated women presented a high consumption of foods characterizing the Fast-Food eating pattern compared to older and less educated ones, respectively. (AU)

OVERWEIGHT IN ADOLESCENTS: FOOD INSECURITY AND MULTIFACTORIALITY IN SEMIARID REGIONS OF PERNAMBUCO.

OBJECTIVE: To investigate context of overweight adolescents from the semiarid and rural areas of Pernambuco, considering the multifactorial nature of the determinants of being overweight, and the food and nutritional insecurity conditions of the region. METHODS: A population based cross-sectional study was conducted from September to October 2015. The nutritional status of adolescents was assessed by body mass index (BMI) and classified by the BMI/Age indicator, according to sex. To analyze the factors associated with being overweight, the variables were grouped into: socioeconomic, demographic, environmental, lifestyle, psychological, biological and food and nutritional security. Poisson regression was used to verify the association between being overweight and independent variables. RESULTS: The prevalence of excessive weight found was 20.1%, namely: 13.4% overweight and 6.7% obese. After adjusting for the confounding variables, the variables: occupancy situation (rented house), alcohol consumption, food security and light food insecurity, body perception (overweight and obese) and age range (10 to 14 years), were associated with being overweight. High food and nutritional insecurity was identified in 80.4% of the population. The moderate and severe forms were more frequent, and precarious social conditions were still prevalent in the region. CONCLUSIONS: The prevalence of being overweight was high, exceeding the expected for a population with better living conditions. The determinants of being overweight were: alcohol consumption, occupancy situation, self-perceived weight, age and food security/mild food insecurity.

Overweight in adolescents: food insecurity and multifactoriality in semiarid regions of pernambuco / Excesso de peso em adolescentes: insegurança alimentar e multifatorialidade no cenário do semiárido de pernambuco

ABSTRACT Objective: To investigate context of overweight adolescents from the semiarid and rural areas of Pernambuco, considering the multifactorial nature of the determinants of being overweight, and the food and nutritional insecurity conditions of the region. Methods: A population based cross-sectional study was conducted from September to October 2015. The nutritional status of adolescents was assessed by body mass index (BMI) and classified by the BMI/Age indicator, according to sex. To analyze the factors associated with being overweight, the variables were grouped into: socioeconomic, demographic, environmental, lifestyle, psychological, biological and food and nutritional security. Poisson regression was used to verify the association between being overweight and independent variables. Results: The prevalence of excessive weight found was 20.1%, namely: 13.4% overweight and 6.7% obese. After adjusting for the confounding variables, the variables: occupancy situation (rented house), alcohol consumption, food security and light food insecurity, body perception (overweight and obese) and age range (10 to 14 years), were associated with being overweight. High food and nutritional insecurity was identified in 80.4% of the population. The moderate and severe forms were more frequent, and precarious social conditions were still prevalent in the region. Conclusions: The prevalence of being overweight was high, exceeding the expected for a population with better living conditions. The determinants of being overweight were: alcohol consumption, occupancy situation, self-perceived weight, age and food security/mild food insecurity.

RESUMO Objetivo: Investigar o excesso de peso em adolescentes do Sertão e Agreste de Pernambuco, considerando a multifatoriedade dos determinantes do excesso de peso e as condições de insegurança alimentar e nutricional da região. Métodos: Estudo transversal, de base populacional, realizado no período de setembro a outubro de 2015. O estado nutricional dos adolescentes foi avaliado pelo índice de massa corpórea (IMC) e classificado pelo indicador IMC/idade, segundo o sexo. Para analisar os fatores associados ao excesso de peso, as variáveis foram agrupadas em: socioeconômicas, demográficas, ambientais, de estilo de vida, psicológicas, biológicas e segurança alimentar e nutricional. A regressão de Poisson foi utilizada para verificar a associação entre o excesso de peso e as variáveis independentes. Resultados: A prevalência de excesso de peso encontrada foi de 20,1%, sendo 13,4% de sobrepeso e 6,7% de obesidade. Após o ajuste para as variáveis de confusão, as variáveis regime de ocupação (casa cedida, alugada), consumo de álcool, segurança alimentar, insegurança alimentar leve, percepção corporal (sobrepeso e obesidade) e faixa etária (10 a 14 anos) mostraram-se associadas ao excesso de peso. Destaca-se a elevada insegurança alimentar e nutricional, em 80,4% da população, sendo as formas moderadas e graves as mais frequentes, como também as precárias condições sociais ainda prevalentes na região. Conclusões: A prevalência de excesso de peso foi elevada, superando o esperado para uma população com melhores condições de vida. Os determinantes do excesso de peso foram: consumo de álcool, regime de ocupação, autopercepção do peso, faixa etária e segurança alimentar/insegurança alimentar leve.