ABSTRACT
Com o objetivo de caracterizar o perfil epidemiológico e laboratorial de pacientes com doença de Crohn (DC), conduziu-se a presente série de casos, englobando 26 indivíduos atendidos no Hospital das Clínicas da Universidade Federal de Pernambuco. Coletaram-se dados epidemiológicos, clínicos e bioquímicos, incluindo a relação Proteína C-Reativa (PCR) /Albumina. A amostra apresentou idade de 41,3±13,2 anos e 100,0% estava em remissão da DC. A relação PCR/Albumina foi elevada em 76,9% dos participantes, principalmente naqueles com menor tempo da DC e com alta Velocidade de Hemossedimentação (p≤0,05). Os indivíduos desta casuística revelaram características típicas da DC e valores elevados da relação PCR/Albumina.
In order to characterize the epidemiological and laboratory profile of patients with Crohn's disease (CD), this case-series was conducted, involving 26 patients treated at Hospital das Clinicas, Federal University of Pernambuco. Epidemiological, clinical and biochemical data were collected, including the C-Reactive Protein (CRP)/Albumin ratio. The sample had mean age of 41.3 ± 13.2 years and 100.0% were in remission of CD. CRP/Albumin ratio was elevated in 76.9% of the patients, especially in those with shorter duration of CD and higher values of erythrocyte sedimentation rate (p≤0.05). The patients of this study showed typical characteristics of CD and high CRP/Albumin ratio.
Subject(s)
Humans , Male , Female , Adult , C-Reactive Protein/analysis , Crohn Disease/epidemiology , Albumins/analysis , Biomarkers/analysis , Crohn Disease/diagnosisABSTRACT
Chlamydia trachomatis (CT) is the most common bacterial cause of sexually transmitted disease. High-risk human papillomavirus (HR-HPV) is considered the main etiological agent for cervical neoplasia. Evidences showed that the presence of co-infection of CT and HR-HPV plays a central role in the etiology of cervical intraepithelial neoplasia (CIN) and cervical cancer. The goals of this study were: evaluate the human papillomavirus (HPV) and CT prevalence among Brazilian women with abnormal cytology and provide the effect of this association on the severity of cervical neoplasia. The population of this study was composed by 142 women with incident histological incidence of CIN grades I, II, III or cervical cancer from Recife, Northeast of Brazil. The polymerase chain reaction method on a cervical brush specimen was used to detect both agents and the automatic sequencing method was used for HPV genotyping assay. The prevalence of HPV and CT was 100 and 24.65 %, respectively. Thirteen types of HPV were detected; HPV 16, 18, 31 and 33 were the most common. The most prevalent HPV types were HPV 16 and 18. A significant association between CT positive and HPV 16 infection was found (p < 0.0106; OR = 5.31; 95 % IC 1.59-17.67). In the study population, there was diversity of HPV infections, with high-risk types being the most common. Also, the data collected suggest that CT infection may play an important role in the natural history of HPV infection.
