ABSTRACT
During septic intoxication in diffuse peritonitis poisoning is accompanied by circulatory and volemic failures, considerable changes in immune status, basically of the cellular component of T-system. Several sorption methods were applied which produced different effects on the pathologic process. Extracorporeal application of spleen-xeno and ultraviolet irradiation of autoblood considerably increased the immune reactivity. Plasmapheresis and hemosorption administration had low immunocorrective effect. It is believed reasonable to employ a combination detoxication methods.
Subject(s)
Immunotherapy/methods , Peritonitis/therapy , Sorption Detoxification/methods , Acute Disease , Animals , Dogs , Evaluation Studies as Topic , Immunity, Cellular , Immunologic Tests , Male , Peritonitis/immunologyABSTRACT
An immunocorrective effect of current methods of detoxication in experimental acute destructive pancreatitis was studied on 40 mongrel male dogs with body mass 13-15 kg. It was found that destructive pancreatitis is associated with a decrease in immunological reactivity, mainly in T-cell immunity component. Application of spleen xeno and ultraviolet irradiation of autoblood proved most effective as early treatment. On treatment day 3-7 immunological indices recovered and even increased after hemosorption.
Subject(s)
Immunotherapy/methods , Pancreatitis/therapy , Acute Disease , Animals , B-Lymphocytes/immunology , Combined Modality Therapy/methods , Dogs , Immunity, Cellular , Leukocyte Count , Male , Pancreatitis/immunology , Sorption Detoxification/methods , T-Lymphocytes/immunologyABSTRACT
Thus, basing on the data obtained it was stated that the destructive pancreatitis is always accompanied by intoxication. A certain weakening of the immune mechanisms took place, mainly of its T-cellular chain. Detox methods of treatment had different effects on the organism. The most effective among them happened to be plasmapheresis and spleen-xeno as they significantly decrease hyperfermentation and toxemia. The application of hemosorption and ultra-violet irradiation of blood had favourable immunocorrective effect at the early stage. It should be noted that the application of spleen-xeno was normalizing the immune mechanisms at the later stage of experimental acute pancreatitis.
