[Connection of functional characteristics and ultrastructure of the lung and myocardium in hypoxia and srtess].

The estimation of changes in breathing, circulation, gas exchange, lipid peroxidation, which can be connected with or determined by morphofunctional state of lung tissue and myocardium in rats under acute hypoxic hypoxia, acute dose hemorrhage and immobilization stress were made. Such approach is important not only from theoretical point of view, for the elucidation and definition of mechanisms which are responsible for function of oxygen-transport systems under unfavorable influences on the organism, but present particularly practical interest. The exposure of correlation between structure and function in investigated organs may permit to forecast the availability of some ultrastructural violations under ventilation or circulation changes in the organism.

[Correlation of tissue respiration and some mitochondria stereometric characteristics of the lung tissue in different modifications of hypoxic hypoxia].

In experiments on the adult white laboratory rats the correlation of tissue respiration and some morpho- and stereometric characteristics of mitochondria in lung tissue under breathing by air and gas mixture with 7% O2 in N2 was investigated. The following agents were used as modulators: indomethacin, a blockator of cyclooxygenase way of arachidonic acid metabolism; quercetin and linoleil of hydroxamic acid, blockators of lipooxygenase way ofarachidonic acid metabolism; taurine, an antihypoxant and energy source under hypoxic conditions; lipin-antihypoxant with significant membrane protective effect. It was shown, that the respiration intensity of tissue homogenate, not only of its mitochondrial fraction, closely connected with structural organization of mitochondria. It was demonstrated that changes of O2 concentration in gas mixture lead to the alteration of interrelation between O2 consumption and stereometric characteristics of mitochondria: in normoxia the intimate correlation was established with number of mitochondria and its total surface; in hypoxia such correlation was established with mitochondria diameter and number of structurally damage organelles. Pharmacological modulation factors play in this process not so significant role.

[Correlation between the thickness of air-blood barrier of the lung and main indices of respiration during changes in oxygen concentration]. / Vzaiemozv'iazok tovshchyny aerohematychnoho bar'iera lehen' ta osnovnykh pokaznykiv dykhannia pry zmini kontsentratsiï kysniu.

In experiments on adult white laboratory rats the correlation among external respiration, gas exchange and blood O2 transport under breathing by air and gas mixtures with 40%, 14.5%, 11% and 7% O2 in N2 was investigated. It was demonstrated the narrow structural-functional interrelation in oxygen transport system. The thickness of air-blood barrier (ABB) correlates not only with the external respiration and diffusion capacity of lung, but with parameters, which are not directly connected with the state of lung tissue, such as oxygen content in venous blood, VaO2/VO2 and even with circulation volume. The existence of narrow correlation of ABB thickness and the most of investigated parameters permits to prognosticate the availability of structural disturbances in the presence of external respiration, gas exchange and blood O2 transport changes.

[Effect of polymer material thermal destruction products on external respiration and acid-base status of blood]. / Vplyv produktiv termodestruktsiï polimernykh materialiv na zovnishnie dykhannia ta kyslotno-luzhnyi stan krovi.

In experiments on white laboratory rats the influence of fluor-, cyan- and sulfur-containing gaseous products, formed under thermodestruction of synthetic materials in normal and high environmental temperature on external respiration and some parameters of acid-base blood values was investigated. It was shown, that external respiration, due to considerable it depression, could not compensate neither hypoxic state, accompanied by hypoxemia, nor hypercapnia and acidosis, developed under the influence of toxic agents both in normal environmental temperature and in hyperthermia.