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1.
J Org Chem ; 66(11): 4055-7, 2001 Jun 01.
Article in English | MEDLINE | ID: mdl-11375036
2.
Trop Med Int Health ; 3(9): 721-7, 1998 Sep.
Article in English | MEDLINE | ID: mdl-9754667

ABSTRACT

We performed a series of ELISAs to evaluate the diagnostic significance of two Schistosoma mansoni proteins, Sm31 (cysteine proteinase, cathepsin B) and Sm32 (asparaginyl endopeptidase). Our study populations were chosen from two villages in an endemic area close to Alexandria. Using fusion proteins MS2-Sm31 and MS2-Sm32 as antigens, 70% and 78.9%, respectively, of patient sera from 134 parasitologically confirmed cases reacted positively. The percentage of seropositivity increased to 84.5% when parasite-derived proteins Sm31 and Sm32 were used. The serum levels of antibodies to these two proteins in recombinant or native forms do not correlate with intensity of infection and hence are detected even when egg counts are low, which makes proteins Sm31 and Sm32 useful antigens in the identification of S. mansoni infected cases, particularly in endemic areas in Egypt.


Subject(s)
Antibodies, Helminth/blood , Antigens, Helminth/immunology , Cysteine Endopeptidases/immunology , Endemic Diseases , Helminth Proteins/immunology , Plant Proteins , Schistosoma mansoni/immunology , Schistosomiasis mansoni/diagnosis , Schistosomiasis mansoni/immunology , Adolescent , Adult , Animals , Case-Control Studies , Child , Child, Preschool , Egypt/epidemiology , Enzyme-Linked Immunosorbent Assay , Feces/parasitology , Female , Humans , Male , Middle Aged , Parasite Egg Count , Reproducibility of Results , Schistosomiasis mansoni/epidemiology , Sensitivity and Specificity , Seroepidemiologic Studies , Severity of Illness Index
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