Automated Multi-Class Facial Syndrome Classification Using Transfer Learning Techniques.

Genetic disorders affect over 6% of the global population and pose substantial obstacles to healthcare systems. Early identification of these rare facial genetic disorders is essential for managing related medical complexities and health issues. Many people consider the existing screening techniques inadequate, often leading to a diagnosis several years after birth. This study evaluated the efficacy of deep learning-based classifier models for accurately recognizing dysmorphic characteristics using facial photos. This study proposes a multi-class facial syndrome classification framework that encompasses a unique combination of diseases not previously examined together. The study focused on distinguishing between individuals with four specific genetic disorders (Down syndrome, Noonan syndrome, Turner syndrome, and Williams syndrome) and healthy controls. We investigated how well fine-tuning a few well-known convolutional neural network (CNN)-based pre-trained models-including VGG16, ResNet-50, ResNet152, and VGG-Face-worked for the multi-class facial syndrome classification task. We obtained the most encouraging results by adjusting the VGG-Face model. The proposed fine-tuned VGG-Face model not only demonstrated the best performance in this study, but it also performed better than other state-of-the-art pre-trained CNN models for the multi-class facial syndrome classification task. The fine-tuned model achieved both accuracy and an F1-Score of 90%, indicating significant progress in accurately detecting the specified genetic disorders.

Multimodal Medical Image Fusion Using Stacked Auto-encoder in NSCT Domain.

Medical image fusion is a process that aims to merge the important information from images with different modalities of the same organ of the human body to create a more informative fused image. In recent years, deep learning (DL) methods have achieved significant breakthroughs in the field of image fusion because of their great efficiency. The DL methods in image fusion have become an active topic due to their high feature extraction and data representation ability. In this work, stacked sparse auto-encoder (SSAE), a general category of deep neural networks, is exploited in medical image fusion. The SSAE is an efficient technique for unsupervised feature extraction. It has high capability of complex data representation. The proposed fusion method is carried as follows. Firstly, the source images are decomposed into low- and high-frequency coefficient sub-bands with the non-subsampled contourlet transform (NSCT). The NSCT is a flexible multi-scale decomposition technique, and  it is superior to traditional decomposition techniques in several aspects. After that, the SSAE is implemented for feature extraction to obtain a sparse and deep representation from high-frequency coefficients. Then, the spatial frequencies are computed for the obtained features to be used for high-frequency coefficient fusion. After that, a maximum-based fusion rule is applied to fuse the low-frequency sub-band coefficients. The final integrated image is acquired by applying the inverse NSCT. The proposed method has been applied and assessed on various groups of medical image modalities. Experimental results prove that the proposed method could effectively merge the multimodal medical images, while preserving the detail information, perfectly.