Does concomitant gout in septic arthritis affect surgical outcomes?

BACKGROUND: We aim to review and describe the proportion of patients with co-existing gout amongst patients with surgical treated septic arthritis, characterize their clinical presentation, outcomes and complications compared to patients with native joint septic arthritis. METHODS: Sixty-one patients with surgically treated primary joint septic arthritis were identified from the period of January 2011 to December 2016. There were 13 (21.3%) patients with co-existing septic arthritis and crystal proven gout. Pertinent details such as demographics, comorbidities, clinical features on presentation, infection markers, number of surgeries, length of stay (LOS) in general and individual LOS in supportive care units, limb amputations, readmissions and mortality were reviewed. Multiple linear and logistic regression models were used to control for confounders during analysis. RESULTS: The average age of patients was 60.8 years (range: 23-87 years). The patients with gout are associated with comorbidities such as being hypertensive, hyperlipidemia and renal impaired. They tend to present with ankle joint involvement (46.2% vs 8.3%; p = 0.004) while septic arthritis patients without gout tend to present with knee joint involvement (75% vs 46.2%; p = 0.046). In terms of complications, up to two thirds of them require supportive care in the High Dependency Unit and/or Intensive Care Unit during treatment (61.5% vs 29.2%; p = 0.031) and having gout with septic arthritis independently predicted a significant increase in LOS by an additional 12.6 days on average (95% CI: 2.11 - 23.03; p = 0.019). They are also more likely to end up with limb amputation (23.1% vs 0%; p = 0.008) on univariate analysis. CONCLUSION: Gout accompanying septic arthritis in the same joint is potentially associated with major systemic and joint related sequela, complications in terms of prolonged hospital stay, need for complex care and risk for limb amputation. Our findings further indicate the value and need for well-designed prospective controlled cohort studies to explore the relationship between gout and septic arthritis.

Understanding "Kyphosis" and "Lordosis" for Sagittal Balancing in Two Common Standing Postures.

STUDY DESIGN: Cross-sectional radiographic comparison study. OBJECTIVE: The aim of this study was to understand whole-body balancing in directed and natural standing postures, through comparison of kypholordotic ratios on whole-body radiographs of young, healthy subjects. SUMMARY OF BACKGROUND DATA: Recent studies highlighted the importance of understanding whole-body balancing, proposing the use of the more physiological natural standing posture, together with the conventional directed standing posture, for imaging. METHODS: Sixty healthy, 21-year-old subjects (36 males, 24 females) were recruited. EOS whole-body radiographs of subjects in directed and natural standing postures were obtained. Radiographic parameters compared include C2-sagittal vertical axis (C2-SVA), C7-SVA, C2-7-SVA, global cervical angles (C0-T1 and C2-C7), regional cervical angles (C0-C2, C2-C4, C4-C7), T1-slope, global thoracic angles (T1-T12 and T1-inflection vertebra [Inf]), thoracolumbar angle (T11-L2), global lumbar angles (T12-S1 and Inf-S1), pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), spinocoxa angle (SCA), and femoral alignment angle (FAA). Kypholordotic ratios of T1-12/T12-S1, T1-Inf/Inf-S1, Tl-Inf/SCA, and (T1-Inf + FAA)/(T1-slope + SCA) were calculated and compared. RESULTS: Compared to directed standing, natural standing has greater C2-SVA and C7-SVA, more lordotic global and regional cervical angles (except C0-2 angle), higher T1-slope, larger T1- T12 and T1-Inf kyphotic angles, smaller T12-S1 and Inf-S1 lordotic angles, larger PT, more lordotic SCA, and smaller SS and FAA angles. T1-12/T12-S1 and T1-Inf/Inf-S1 ratios in natural standing, and (Tl-Inf + FAA)/(T1-slope + SCA) ratio in both postures approximate 1. There were significant differences between postures for Tl-l2/Tl2-Sl, Tl-Inf/Inf-Sl and Tl-Inf/SCA ratios. CONCLUSION: Whole-body balancing requires understanding of the balance between kyphosis and lordosis, which varies with the posture of patients. Analysis of kypholordotic ratios obtained in this study allude to the importance of performing whole-body imaging in the directed standing posture, and whole-spine or whole-body imaging in the natural standing posture, so as to fully understand spinal and whole body balancing for spinal realignment surgeries.Level of Evidence: Level 3.