Incidence and determinants of nosocomial infection among hospital admitted adult chronic disease patients in University of Gondar Comprehensive Specialized Hospital, North-West Ethiopia, 2016-2020.

Background: Nosocomial infections are major public health problem which affects more than 100 million patients each year globally. This leads to prolonged hospital stays, a high mortality rate, and a vast financial burden to the healthcare system as well as the patients. This study aimed to find out the incidence of nosocomial infections and determinant factors among admitted adult chronic illness patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. Methods: An institutional-based retrospective follow-up study design was employed among 597 respondents. The secondary data was collected from April 15 to May 15, 2021. A computer-generated random sampling technique was used to select a total of 599 patients using Open-epi software. Structured checklists were used to collect data. For data entry and analysis Epi-Data version 4.6 and STATA 16 were used respectively. To identify statistically significant variables Cox-regressions (univariable and multivariable) were performed. To declare statistically significant variables based on p < 0.05 in the multivariable Cox-regression model, adjusted hazard ratio with 95% CI was used. Results: A total of 597(99.6%) adult chronic illness patients were included in the study. Of these, 53 (8.88%) participants developed nosocomial infections and the incidence rate of nosocomial infection was 6.6 per 1,000 person-days observation. In this study, not taking antibiotics (AHR = 2.74, 95% CI: 1.49, 5.04), using mechanical ventilation (AHR = 2.67, 95% CI: 1.36, 5.26), being on urinary catheter (AHR = 4.62, 95% CI: 2.22, 9.65), being on intravenous catheter (AHR = 3.42, 95% CI: 1.22, 9.61) and length of hospital stay >20 days (AHR = 2.66, 95% CI: 1.43, 4.94) were significantly associated with nosocomial infections. Conclusions: The findings have indicated that the incidence of nosocomial infection was low. No taking antibiotics, intravenous insertion, mechanical ventilation, length of hospital stay, and urinary catheterization were the predictors for the development of nosocomial infection. Therefore, we recommend that the healthcare providers need to give emphasis on infection prevention and control in the institution on these factors that have a significant effect on nosocomial infection.

COVID-19 vaccine acceptance and associated factors among women attending antenatal and postnatal cares in Central Gondar Zone public hospitals, Northwest Ethiopia.

INTRODUCTION: The Coronavirus disease 2019 pandemic is a public health problem, which caused a major impact on morbidity and mortality around the world. Even though an effective vaccine is the most awaited resolution for the pandemic, little is known about COVID-19 vaccine acceptance in Ethiopia. This study aimed to assess vaccine acceptance and its associated factors among pregnant and postnatal mothers. METHOD: Institution-based cross-sectional study was conducted on 527 pregnant and postnatal mothers from August 15 to September 15, 2021. Data were collected using an interviewer-administered structured questionnaire. A systematic random sampling technique was used to select the study participants. Epi-Data version 4.6 and Stata 16 software were used for data entry and analysis respectively. Participant characteristics and rate of vaccine acceptance were presented using descriptive statistics. Multi-variable logistic regression was performed to identify statistically significant variables. Adjusted odds ratio with 95% confidence interval was used to declare statistical significance based on p < 0.05 in the multivariable logistic regression model. RESULT: The overall prevalence of intent to accept COVID-19 vaccine was 62.04% (95% CI: 57.65, 66.25). Of those 40.08% were pregnant mothers and 21.97% of them were postpartum mothers. Urban residence (AOR = 2.03, 95% CI: 1.09-3.77), respondents who were worry about COVID-19 disease (AOR = 3.46, 95% CI: 2.16-5.52), and participants who had favorable attitude towards vaccine (AOR = 8.54, 95% CI: 5.18-14.08) were significantly associated with COVID-19 vaccine acceptance. CONCLUSION: Our findings showed that the willingness to accept COVID-19 vaccination was low. Residence, worry about COVID-19 disease, and attitudes towards vaccine were factors significantly associated with COVID-19 vaccine acceptance. Evidence-based and clear information on COVID-19 vaccines should be provided to pregnant and postnatal mothers for both rural and urban residences to improve attitude towards the COVID-19 vaccine and increase vaccination rates.