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1.
Article in English | MEDLINE | ID: mdl-38770242

ABSTRACT

Social telepresence robots (i.e., telerobots) are used for social and learning experiences by children. However, most (if not all) commercially available telerobot bodies were designed for adults in corporate or healthcare settings. Due to an adult-focused market, telerobot design has typically not considered important factors such as age and physical aspect in the design of robot bodies. To better understand how peer interactants can facilitate the identities of remote children through personalization of robot bodies, we conducted an exploratory study to evaluate collaborative robot personalization. In this study, child participants (N=28) attended an interactive lesson on robots in our society. After the lesson, participants interacted with two telerobots for personalization activities and a robot fashion show. Finally, participants completed an artwork activity on robot design. Initial findings from this study will inform our continued work on telepresence robots for virtual inclusion and improved educational experiences of remote children and their peers.

2.
Clin Sci (Lond) ; 132(2): 295-312, 2018 01 31.
Article in English | MEDLINE | ID: mdl-29167317

ABSTRACT

Bariatric surgery is increasingly employed to improve fertility and reduce obesity-related co-morbidities in obese women. Surgical weight loss not only improves the chance of conception but reduces the risk of pregnancy complications including pre-eclampsia, gestational diabetes, and macrosomia. However, bariatric procedures increase the incidence of intrauterine growth restriction (IUGR), fetal demise, thromboembolism, and other gestational disorders. Using our rodent model of vertical sleeve gastrectomy (VSG), we tested the hypothesis that VSG in diet-induced, obese dams would cause immune and placental structural abnormalities that may be responsible for fetal demise during pregnancy. VSG dams studied on gestational day (G) 19 had reduced circulating T-cell (CD3+ and CD8+) populations compared with lean or obese controls. Further, local interleukin (IL) 1ß and IL 1 receptor antagonist (il1rn) cmRNA were increased in placenta of VSG dams. Placental barrier function was also affected, with increased transplacental permeability to small molecules, increased matrix metalloproteinase 9 expression, and increased apoptosis in VSG. Furthermore, we identified increased placental mTOR signaling that may contribute to preserving the body weight of the fetuses during gestation. These changes occurred in the absence of a macronutrient deficit or gestational hypertension in the VSG dams. In summary, previous VSG in dams may contribute to fetal demise by affecting maternal immune system activity and compromise placental integrity.


Subject(s)
Fetal Growth Retardation/pathology , Gastrectomy/methods , Obesity/surgery , Pregnancy Complications/pathology , Animals , Bariatric Surgery/adverse effects , Bariatric Surgery/methods , CD8-Positive T-Lymphocytes/immunology , CD8-Positive T-Lymphocytes/metabolism , Diet, High-Fat/adverse effects , Female , Fetal Growth Retardation/etiology , Fetal Growth Retardation/immunology , Gastrectomy/adverse effects , Gene Expression , Humans , Interleukin-1beta/genetics , Interleukin-1beta/metabolism , Male , Obesity/etiology , Placenta/immunology , Placenta/metabolism , Pregnancy , Pregnancy Complications/etiology , Pregnancy Complications/immunology , Rats, Long-Evans
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