ABSTRACT
Symptomatic knee osteoarthritis is a common complaint of many elderly patients in primary care offices. For those unable or unwilling to undergo knee replacement, the primary practitioners' understanding of the strengths and weaknesses of the available treatment modalities for pain relief is critical to successful in-office counseling and expectation management. Treatment requires a multimodal approach of nonpharmacologic and pharmacologic therapies to achieve a maximal clinical benefit. The focus of this review is on the nonsurgical options for treatment of knee osteoarthritis in patients aged 65 and older.
Subject(s)
Arthralgia , Conservative Treatment/methods , Osteoarthritis, Knee , Aged , Arthralgia/etiology , Arthralgia/therapy , Arthroplasty, Replacement, Knee/methods , Humans , Osteoarthritis, Knee/complications , Osteoarthritis, Knee/physiopathology , Patient SelectionABSTRACT
Symptomatic knee osteoarthritis is a common complaint of many elderly patients in primary care offices. For those unable or unwilling to undergo knee replacement, the primary practitioners' understanding of the strengths and weaknesses of the available treatment modalities for pain relief is critical to successful in-office counseling and expectation management. Treatment requires a multimodal approach of nonpharmacologic and pharmacologic therapies to achieve a maximal clinical benefit. The focus of this review is on the nonsurgical options for treatment of knee osteoarthritis in patients aged 65 and older.
Subject(s)
Arthralgia , Exercise Therapy/methods , Osteoarthritis, Knee/complications , Pain Management/methods , Aged , Arthralgia/diagnosis , Arthralgia/etiology , Arthralgia/therapy , Humans , Pain MeasurementABSTRACT
Weber-Christian disease (W-CD) is associated with relapsing nodular panniculitis and a variety of systemic findings. Renal parenchymal involvement has been rarely reported. The authors describe a case of nephrotic syndrome in an African-American man with a W-CD flare. The patient had chills and low-grade fever with painful lower extremity skin lesions. A renal biopsy demonstrated the tip variant of focal segmental glomerulosclerosis (FSGS). The kidney biopsy also suggested parenchymal involvement by W-CD disease, with supportive ultrastructural findings. The synchronous W-CD flare and biopsy-proven FSGS and the rapid and sustained response of both to limited treatment suggest a causative association.
Subject(s)
Glomerulosclerosis, Focal Segmental/etiology , Kidney/pathology , Panniculitis, Nodular Nonsuppurative/complications , Biopsy , Glomerulosclerosis, Focal Segmental/drug therapy , Glomerulosclerosis, Focal Segmental/pathology , Humans , Kidney/ultrastructure , Male , Microscopy, Electron , Middle Aged , Nephrotic Syndrome/etiology , Nephrotic Syndrome/pathology , Panniculitis, Nodular Nonsuppurative/drug therapy , Panniculitis, Nodular Nonsuppurative/pathology , Predictive Value of Tests , Steroids/therapeutic useABSTRACT
Ankylosing spondylitis is a chronic inflammatory condition that usually affects young men. Cardiac dysfunction and pulmonary disease are well-known and commonly reported extra-articular manifestation, associated with ankylosing spondylitis (AS). AS has also been reported to be specifically associated with aortitis, aortic valve diseases, conduction disturbances, cardiomyopathy and ischemic heart disease. The pulmonary manifestations of the disease include fibrosis of the upper lobes, interstitial lung disease, ventilatory impairment due to chest wall restriction, sleep apnea, and spontaneous pneumothorax. They are many reports detailing pathophysiology, hypothesized mechanisms leading to these derangements, and estimated prevalence of such findings in the AS populations. At this time, there are no clear guidelines regarding a stepwise approach to screen these patients for cardiovascular and pulmonary complications.
ABSTRACT
West Nile virus (WNV) was isolated from the brains of 3 horses that died from encephalitis in February 2006. The horses were from different farms in central Argentina and had not traveled outside the country. This is the first isolation of WNV in South America.
Subject(s)
Horse Diseases/virology , West Nile Fever/veterinary , West Nile virus/isolation & purification , Animals , Argentina/epidemiology , Base Sequence/genetics , Brain/virology , Horse Diseases/epidemiology , Horses , Molecular Sequence Data , Phylogeny , Reverse Transcriptase Polymerase Chain Reaction , West Nile Fever/epidemiology , West Nile Fever/virology , West Nile virus/geneticsABSTRACT
BACKGROUND: The purpose of this study was to determine the numeracy information included in three prominent breast cancer Web sites. METHODS: A content analysis was performed, grouping numeracy items into 15 categories. Interrater reliability was high. RESULTS: Of the 3,206 items identified, 14.3% were numbers, 33.9% were descriptive measures (e.g., many, lower), 27.3% were statistical terms (e.g., predictive, risk), and 12.4% were temporal terms (e.g., before, always). CONCLUSIONS: Findings suggest that there is an abundance of numeric information presented in breast cancer Web sites, much of which may be conceptually too advanced for the intended audience.