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Phytochemistry ; 65(21): 2903-7, 2004 Nov.
Article in English | MEDLINE | ID: mdl-15501259

ABSTRACT

A new axially chiral naphthylisoquinoline alkaloid, ancistroheynine B (7), has been isolated from the leaves of the Indian liana Ancistrocladus heyneanus Wall., along with two known related alkaloids, ancistrocladidine (3) and ancistrotanzanine C (6), which are 7,3'-coupled, too. The structural elucidation was achieved by chemical, spectroscopic, and chiroptical methods. Biological activities of ancistroheynine B against the pathogens of malaria, leishmaniasis, Chagas' disease, and African sleeping sickness were evaluated.


Subject(s)
Alkaloids/isolation & purification , Magnoliopsida/chemistry , Alkaloids/pharmacology , Antiprotozoal Agents/isolation & purification , Isoquinolines/isolation & purification , Magnetic Resonance Spectroscopy , Molecular Structure , Naphthalenes/isolation & purification , Naphthols/isolation & purification
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