An Initial Assessment of the Correlation Between Virtual Reality and Paper and Pencil Line Bisection Test Results.

Objective: To make an initial assessment of the correlation between immersive virtual reality-based (ILBT) line bisection testing and paper-and-pencil-based line bisection (PLBT) testing in healthy subjects. Design: Diagnostic study. Setting: Research laboratory. Participants: Twenty healthy adults (51.5 [11.0] years old, 55% women; N=20). Interventions: Participants underwent an ILBT and a conventional PLBT in near space (NS) and more distant space (MDS). Correlations between the ILBT and PLBT, deviation rates in the NS and MDS, horizontal gaze distribution, and presence of virtual reality sickness (VRS) were evaluated. Main Outcome Measures: Correlation between the deviation rates of the PLBT and ILBT. Results: There was no significant correlation between the ILBT and PLBT for evaluating the deviation rate of the line bisection test (LBT). There was no significant difference in the deviation rate of the LBTs between the NS and MDS, but there was a significant difference in the horizontal line-of-sight distribution. VRS was not observed as an adverse event. Conclusions: In healthy adult subjects, our results suggested that there was no significant correlation between the deviation rates of the ILBT and PLBT. We also found that the ILBT is a useful and safe method for evaluating the horizontal line-of-sight distribution and percentage deviation of line segments from the center in the NS and MDS without inducing VRS.

Effects of Walking With a Cane on Frontal Plane Hip Joint Loading in Patients With Late-Stage Unilateral Hip Osteoarthritis.

Objective: To investigate the effects of walking with a cane on frontal plain bilateral hip joint loading in patients with late-stage unilateral hip osteoarthritis (OA). Design: Nonrandomized experimental design. Setting: Urban inpatient hospital. Participants: Adults (men, n=10; women, n=17) with osteoarthritis who were scheduled for total hip arthroplasty (N=27). Intervention: Gait with and without a T-cane was assessed using a 3-dimensional motion analysis system. Main Outcome Measures: Peak hip adduction moment and hip adduction moment impulse, vertical ground reaction force, and ground reaction force impulse were assessed under 4 different conditions: OA side vs non-OA side with non-cane gait, OA side vs non-OA side with cane gait, non-cane vs cane gait on OA side, and non-cane vs cane gait on non-OA side. The lateral trunk lean angle in the stance phase on both sides was compared between with and without a cane. Pain during walking with and without a cane was also determined using a visual analog scale (0=no pain; 100=most painful). Results: Walking with a cane reduced the peak hip adduction moment from an average of 0.76 to 0.57 Nm/kg (reduction approximately 25%) and the mean hip adduction moment impulse from 50.58 to 42.78 Nm/kg (reduction approximately 15%) on the affected side. Walking with a cane reduced the peak ground reaction force from an average of 10.15 to 9.20 N/kg but did not markedly affect the mean ground reaction force impulse on the affected side. The mean impulse of vertical ground force and hip adduction moment on the nonaffected side with a T-cane was larger than that without a cane (940.4 vs 899.2, 73.7 vs 68.8, respectively), albeit without statistical significance. The mean lateral trunk lean angle on the affected side was 5.85±3.95 degrees with a non-cane gait and 4.46±2.66 degrees with a T-cane gait, showing a significant difference. Furthermore, walking with a cane was associated with a significant decrease in the visual analog scale of pain from 42.1 to 26.4. Conclusion: These findings indicate that walking with a cane reduces the load and pain on the affected hip joint. The effect of the cane on the trunk lean was small, but it is worth noting that walking with a cane may increase the load on the healthy side.

Functional Recovery after Rehabilitation in Patients with Post-stroke Severe Hemiplegia.

Objectives: Stroke patients with hemiplegia can sometimes achieve independent life at home or in light care facilities after rehabilitation. This study examined the outcomes of rehabilitation in stroke patients with severe hemiplegia. Methods: This study included 50 patients with Brunnstrom recovery stage I-II hemiplegia at the start of rehabilitation for stroke. Good outcome after rehabilitation was defined as independent life with functional independence measure (FIM) score of 100 or greater. Predictors for post-rehabilitation functional recovery were statistically analyzed. Results: FIM scores of 100 or greater in 12 of 50 patients (24%) allowed independent life after stroke rehabilitation. According to univariate analysis, factors associated with a FIM score of 100 or greater and good prognosis after rehabilitation were younger age (<70 years), paralysis caused by intracerebral hematoma (ICH), no cortical lesions, short time from admission to comprehensive inpatient rehabilitation (CIR) for stroke (within 1 month), and good status at the start of early rehabilitation and CIR. Eleven of the 12 patients with good prognosis (FIM ≥100) had ICH and a basal ganglia lesion with no cortical damage. Analysis of the location of lesions suggested that many patients with basal ganglia ICH lesions and little cortical involvement have good prognoses. Conclusions: Stroke patients with severe hemiplegia showed a slightly different distribution of lesions between ICH and cerebral ischemia. Cortical involvement may be a prognostic factor for outcome after rehabilitation in stroke patients with severe hemiplegia. More aggressive rehabilitation interventions may be important for patients with severe hemiplegia, especially without cortical involvement.

Maximum Standardized Uptake Value on Positron Emission Tomography is Associated With More Advanced Disease and High-risk Features in Lung Adenocarcinoma.

18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) has been widely used for preoperative staging of lung adenocarcinomas. The aim of this study was to determine whether a high maximum standardized uptake value (SUVmax) could correlate with pathological characteristics in those patients. We retrospectively reviewed patients with clinical stage 0-IA lung adenocarcinoma who underwent preoperative 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography followed by curative anatomical resection. To identify more advanced disease and high-risk features, representing visceral pleural involvement, pulmonary metastasis, lymph node involvement, and lymphovascular involvement in resected surgical specimens, univariate and multivariate logistic regression analyses were performed. The optimal cutoff point for the SUVmax was determined by receiver operating characteristic analysis. In 2 groups divided according to the cutoff point, the disease-free survivals were calculated and compared using the Kaplan-Meier method and the log-rank test. More advanced disease and high-risk features were identified in 55 (18.9%) of the 291 patients. SUVmax was significantly correlated with more advanced disease and high-risk features, as did the consolidation/tumor ratio on computed tomography. Only 2 (1.2%) of the 169 patients with a SUVmax <3.20 showed more advanced disease and high-risk features, compared with 43.4% of patients with a SUVmax ≥3.20. The disease-free survival was significantly higher in patients with a SUVmax <3.20 than in those with a SUVmax ≥3.20 (P = 0.002). A high SUVmax correlates with more advanced disease and high-risk features in patients with clinical stage 0-IA lung adenocarcinoma. The SUVmax should be considered when deciding treatment strategy in early-stage lung adenocarcinoma.

Delayed detection of passive motion in shoulders with a rotator cuff tear.

The aim of this study was to test whether or not the threshold to the detection of passive motion (TTDPM) and passive joint position sense on the affected shoulder of patients with rotator cuff tear (RCT) was impaired compared to those on the unaffected side and to investigate the relationship between the tear size and changes in the TTDPM and passive joint position sense induced by RCT. This study included 21 patients with unilateral RCT before arthroscopic rotator cuff repair. To investigate proprioception in this study, we measured the TTDPM and passive joint position sense in abduction and external rotation using an isokinetic dynamometer. The tear size was evaluated intraoperatively under direct arthroscopic visualization. The TTDPM in abduction and external rotation was significantly longer on the affected side than on the unaffected side. However, the angular absolute error in passive joint position sense in abduction and external rotation was not significantly different between the limbs. A comparison according to the tear size impaired proprioception of the TTDPM in the larger tear group showed significantly longer values than in the smaller group. There was impaired proprioception of TTDPM in patients with RCT, and the impaired proprioception was related to tear severity. Impaired proprioception of TTDPM may inhibit consistent muscle recruitment to achieve precise control. Our results suggest that clinicians should consider proprioceptive exercises for impaired proprioception in their treatment for conservative or postoperative patients.

Femoral morphology is associated with development of knee pain after hip fracture injury among older adults: A nine-year retrospective study.

INTRODUCTION: We aimed to clarify differences in femoral morphology associated with post-hip fracture knee pain (PHFKP). METHODS: Medical records and radiographic examinations were retrospectively reviewed to determine the relationship between PHFKP development and femoral morphology. Leg length discrepancy (LLD) and neck-shaft angle discrepancy (NSAD) were measured from hip radiographs. RESULTS: 202 were enrolled, of whom 64 (31.7%) developed PHFKP. The PHFKP group showed more varus NSA. Intertrochanteric femoral fractures (γ-nail or CHS) displayed a more varus NSA. CONCLUSIONS: Femoral morphology (varus NSA) may be involved in the development of PHFKP.

Superior migration of the femoral head in patients with severe hip osteoarthritis influences the gait patterns of the coronal plane.

INTRODUCTION: Patients with hip osteoarthritis (OA) show abnormal movement patterns, including the leaning of the trunk toward the affected limb (Duchenne limp). Patients with severe OA, especially those with OA due to hip dysplasia, show a lateral pelvic drop (Trendelenburg sign). AIM: The aim of this preoperative study is to investigate the relationship between superior migration of the arthritic femoral head, pain, and hip abductor muscle strength, and to clarify the relationship between the coronal plane gait patterns with pain and hip abductor muscle strength. METHODS: The subjects of this study were 18 patients with unilateral hip OA secondary to dysplasia. A radiographic analysis was performed on standardised anteroposterior pelvis films. The abductor muscle strength of the OA hip joint was measured with a handheld dynamometer. The tilt angle of the pelvis and trunk lean angle during gait were obtained using a 3-dimensional motion analysis system. Visual analogue scale (VAS) of pain was obtained after trial. RESULTS: The 2 lateral pelvic angle patterns at the mid-stance of the affected limb during gait were detected. 1 is a pattern that was pelvic rise, and the other was a contralateral pelvic drop. Subjects with pelvic drop showed more superior femoral migration than that with pelvic rise (r = 0.69 p < 0.01). VAS of pain correlate significantly with coronal trunk angle on mid-stance of affected limb during gait (r = 0.761, p < 0.01). CONCLUSION: The pelvic drop Trendelenburg sign was influenced by superior migration of the femoral head, whereas the trunk lean Duchenne limp was found to be affected by pain.

Impact of a Multidisciplinary Round Visit for the Management of Dysphagia Utilizing a Wi-Fi-Based Wireless Flexible Endoscopic Evaluation of Swallowing.

OBJECTIVES: The management of dysphagia requires a multidisciplinary approach, especially in large-scale hospitals. We introduce a novel protocol using a Wi-Fi-based flexible endoscopic evaluation of swallowing (FEES) system and aim to verify its effectiveness in evaluation and rehabilitation of inpatients with dysphagia. METHOD: We conducted novel Wi-Fi-based FEES at the bedside using 3 iPads as monitors and recorders. Functional outcomes of swallowing in 2 different hospitals for acute care with conventional wired or wireless FEES were compared retrospectively. RESULTS: Using the wireless system, we could visit more patients in a short period of time. Furthermore, a large multidisciplinary team was able to be present at the bedside, which made it easy to hold discussions and rapidly devise appropriate rehabilitation strategies. Aspiration pneumonia recurred in a few cases following our intervention with wireless FEES. Functional oral intake score was significantly increased following the intervention. Moreover, the number of deaths during hospitalization using wireless FEES evaluation was lower than those observed using the conventional system. CONCLUSION: Wi-Fi-based wireless FEES system, the first of its kind, allowed our multidisciplinary team to easily and effectively assess inpatients with dysphagia by facilitating simple examinations and intensive transprofessional discussions for patient rehabilitation.

Injuries and disorders among young ice skaters: relationship with generalized joint laxity and tightness.

This study retrospectively investigated 192 teenage speed and figure skaters with prior injuries documented by an athletes' questionnaire, who underwent a physical examination to assess their muscle tightness and generalized joint laxity. In all athletes, the degree of muscle tightness and joint laxity were measured by a standardized physical examination. A descriptive report of the types of injuries showed a predominance of fractures, ligament injuries, enthesitis, and lower back pain. Approximately 5% of all skaters tested positive for tightness, while 25.8% of figure skaters and 15.2% of speed skaters had generalized ligamentous laxity. Statistical testing showed an association between ankle sprains and muscle tightness, and an association between knee enthesitis and muscle tightness in skating athletes. There was also an association between lower back pain and generalized joint laxity, which held true only for the male skaters.

Toe-out angle changes after total knee arthroplasty in patients with varus knee osteoarthritis.

PURPOSE: Toeing-out is a commonly proposed kinematic variable that has been suggested to reduce external knee adduction moment. Analyses of the toe-out angle after total knee arthroplasty (TKA) are useful for obtaining a proper understanding of the abnormal gait caused by varus knee osteoarthritis (OA), as well as performing rehabilitation after arthroplasty. Changes in the toe-out angle after arthroplasty have not yet been defined or analysed. METHODS: The study population consisted of 32 knees in 32 patients with varus knee OA who underwent TKA. The femorotibial angle was evaluated on standing anteroposterior radiographs before and after arthroplasty. The subjects underwent three-dimensional motion capture analyses to measure gait parameters (walking speed, cadence, stride length, step length, step width and the relative length of the single-limb support (SLS) percentage of one gait cycle) and the maximal hip adduction angle in the stance phase, the trunk lean angle in the coronal plane and the toe-out angle before and 4 weeks after arthroplasty. RESULTS: The femorotibial angle on the side of arthroplasty improved after surgery. Among the measured gait parameters, only the SLS percentage increased significantly. The hip adduction angle and toe-out angle on the side of arthroplasty increased significantly after surgery. CONCLUSIONS: The knee alignment and hip adduction angle in the coronal plane and SLS phase were normalized after arthroplasty. The increase in the toe-out angle after arthroplasty may be attributable to the restoration of a normal knee alignment. These findings contribute to obtaining a proper understanding of the abnormal gait caused by varus knee OA and are useful for orthopaedic surgeons and rehabilitation therapists when treating patients after arthroplasty. LEVEL OF EVIDENCE: Prospective study, Level II.

A clinical study of the efficacy of a single session of individual exercise for depressive patients, assessed by the change in saliva free cortisol level.

BACKGROUND: The efficacy of physical exercise as an augmentation to pharmacotherapy with antidepressants for depressive patients has been documented. However, to clarify the effectiveness of exercise in the treatment of depression, it is necessary to distinguish the effect of the exercise itself from the effect of group dynamics. Furthermore, an objective measurement for estimation of the effect is needed. Previous reports adopted a series of group exercises as the exercise intervention and mainly psychometric instruments for the measurement of effectiveness. Therefore, this clinical study was done to examine the effectiveness of a single session of individual exercise on depressive symptoms by assessing the change in saliva free cortisol level, which reflects hypothalamic-pituitary-adrenocortical axis function that is disturbed in depressive patients. METHOD: Eighteen medicated patients, who met the DSM-IV-TR criteria for major depressive disorder, were examined for the change in saliva free cortisol levels and the change in subjective depressive symptoms before and after pedaling a bicycle ergometer for fifteen minutes. Within a month after the exercise session, participants conducted a non-exercise control session, which was sitting quietly at the same time of day as the exercise session. RESULTS: Depressed patients who participated in this study were in remission or in mild depressive state. However, they suffered chronic depression and had disturbed quality of life. The saliva free cortisol level and subjective depressive symptoms significantly decreased after the exercise session. Moreover, the changes in these variables were significantly, positively correlated. On the other hand, although the subjective depressive symptoms improved in the control session, the saliva free cortisol level did not change. CONCLUSION: For the first time in depressive patients, we were able to show a decrease in the saliva free cortisol level due to physical exercise, accompanied by the improvement of subjective depressive symptoms. This identified a possible influence of exercise on the hypothalamic-pituitary-adrenal axis in depression.These results suggest the utility of assessing the effect of physical exercise by saliva free cortisol level in depressive patients who suffer from bio-psycho-social disability.

Immediate effects of physical therapy on gait disturbance and frontal assessment battery in Parkinson's disease.

AIM: To examine whether the Frontal Assessment Battery is associated with the immediate effects of physical therapy on gait disturbance in patients with Parkinson's disease. METHODS: A total of 18 patients with idiopathic Parkinson's disease (Hoehn and Yahr stage range 3-4) who were able to ambulate independently and who were not demented were included. Patients were divided into two groups on the basis of Frontal Assessment Battery scores: the high score group (score ≥ 13, n=11) and the low score group (score ≤ 12, n=7). A 3-D motion analysis system was used to acquire gait parameter data before and after a 30-min physical therapy program. Stride length, step length, cadence, walking velocity, single support time and double support time were measured. The range of motion of the hip, knee and ankle joint, and maximal trunk displacement on the horizontal plane were measured. RESULTS: In the high-score group, significant improvement was observed in walking velocity, stride length and step length, and in the range of motion of the hip and knee joint. Maximal trunk displacement decreased significantly. In contrast, no significant improvement was observed in the low-score group. Multivariate logistic regression analysis showed that Frontal Assessment Battery scores were a predictor of improvement in the range of motion of bilateral hip and knee joints, and maximal trunk displacement. CONCLUSIONS: We showed that the subtests of motor learning of the Frontal Assessment Battery might be associated with the immediate effects of physical therapy on gait disturbance in Parkinson's disease.

Age as a predictor of residual muscle weakness after anterior cruciate ligament reconstruction.

PURPOSE: The objective of this study was to reveal the predicting factors for muscle recovery in the lower extremity after anterior cruciate ligament (ACL) reconstruction. METHODS: One hundred and thirty-five (135) patients who underwent ACL reconstruction using hamstring autograft were evaluated. Exclusion criteria were bilateral ACL injury, chondral treatment and multiple ligament injury. Nonanatomical single-bundle reconstruction (SB) was performed in 79 patients, and anatomical double-bundle reconstruction (DB) was performed in 56 patients. Strength of quadriceps and knee flexion muscles were assessed at 60°/s using a Cybex II dynamometer (Lumex, Ronkonkoma, NY) at 3, 6 and 9 months after ACL reconstruction. Anterior tibial translation and pivot shift test were also evaluated. The medical records were reviewed to extract the following information: age, gender, the amount of pre and postoperative KT 1000, technique of reconstruction (SB or DB) and postoperative knee rotation. RESULTS: No significant difference of muscle recovery in the lower extremity was observed at any time point after ACL reconstruction between the SB and DB groups. The DB group showed significantly better postoperative antero-posterior and rotational knee laxity than the SB group. Logistic regression analysis showed significant correlation with only age and muscle recovery. CONCLUSION: For clinical relevance, there is a risk of muscle recovery delay when ACL reconstruction is performed in elderly patients. Anatomical DB reconstruction resulted in significantly better knee stability, but had no positive effect on muscle recovery. LEVEL OF EVIDENCE: Retrospective study, Level II.

Alternation of trunk movement after arthroplasty in patients with osteoarthritis of the knee.

OBJECTIVE: Trunk movement is important but still little understood after total knee arthroplasty. The alternation of trunk movement was analyzed for use in a postoperative rehabilitation program in the short-term after arthroplasty. MATERIALS AND METHODS: The subjects were 25 patients with knee osteoarthritis (4 males, 21 females). The femorotibial angle was evaluated on standing anteriorposterior radiographs and recorded at pre- and post-arthroplasty. Using three-dimensional motion capture, the gait parameters (cadence, walking speed, stride length, step length, step width), range of motion of lower extremity joints (hip, knee, and ankle), and trunk movement parameters (angle, speed, and displacement) were measured and compared between the pre- and 4th post-arthroplasty week. RESULTS: The femorotibial angles of the arthroplasty side were improved from an average of 189° to 175° after arthroplasty. At the 4th post-arthroplasty week, the range of motion of the hip and knee flexion, hip adduction on the arthroplasty side, and ankle dorsiflexion on the non-arthroplasty side were significantly increased compared to pre-arthroplasty. Among gait parameters, only the stride length increased significantly. Regarding the trunk movement in the coronal plane, the maximal trunk speed to the non-arthroplasty side and maximal trunk displacement to the arthroplasty side were both reduced in a medio-lateral direction; the upward maximal trunk speed on the arthroplasty side increased and the maximal trunk displacement on the non-arthroplasty side decreased significantly in an up-down direction. CONCLUSION: The recovery of hip adduction during the standing phase caused by improvement of knee alignment contributed the reduction of trunk movement to the operated side. In the early post-arthroplasty period, the reduction of trunk movement in the coronal plane is beneficial to maintain trunk balance and prevent falls. Functional recovery of the lower extremities is a long-term process, and sustained functional training is necessary.