1.
Nucleosides Nucleotides Nucleic Acids
; 23(6-7): 1047-51, 2004 Oct.
Article
in English
| MEDLINE
| ID: mdl-15560101
ABSTRACT
New conjugates of bleomycin A5 with oligonucleotides are synthesized. The bleomycin residue was attached to the 3'- or 5'- terminus of hexadecathymidilate via a hexaethylene glycol phosphate linker. Newly designed conjugates were shown to cleave site-specifically both strands of a dsDNA fragment within a triplex. The maximum extent of cleavage for individual strand amounts to 61%.