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1.
G Chir ; 38(3): 143-146, 2017.
Article in English | MEDLINE | ID: mdl-29205145

ABSTRACT

We present a rare case of a 13-year old girl with a bilateral polythelia. We would like to draw attention to this particular mammary malformation.


Subject(s)
Breast Diseases , Nipples/abnormalities , Adolescent , Breast Diseases/pathology , Breast Diseases/surgery , Female , Humans , Nipples/pathology , Nipples/surgery
2.
Ann Surg Oncol ; 16(1): 68-77, 2009 Jan.
Article in English | MEDLINE | ID: mdl-18985271

ABSTRACT

Salvage surgery of recurrent or persistent anal cancer following radiotherapy is often followed by perineal wound complications. We examined survival and perineal wound complications in anal cancer salvage surgery during a 10-year period with primary perineal reconstruction predominantly performed using vertical rectus abdominis myocutaneous (VRAM) flap. Between 1997 and 2006, 49 patients underwent anal cancer salvage surgery. Of these, 48 had primary reconstruction with VRAM. Overall survival was computed by the Kaplan-Meier method and mortality rate ratios (MRRs) by Cox regression. One patient (2%) died within 30 days postoperatively. Postoperative complications necessitated reoperation in eight (16%) patients. We found no major perineal wound infections. Major perineal wound breakdown occurred in the only patient in whom VRAM was not used. Five-year survival was 61% [95% confidence interval (CI) 43-75%]. Free resection margins (R0) were obtained in 78% of patients, with 5-year survival of 75% (95% CI 53-87%). Involved margins, microscopically only (R1) or macroscopically (R2), strongly predicted an adverse outcome [age-adjusted 2-year MRRs (95% CI) R1 vs. R0 = 4.1 (0.7-23.6), R2 vs. R0 = 10.9 (2.2-54.2)]. We conclude that anal cancer salvage surgery can yield long-time survival but obtaining free margins is critical. A low rate of perineal complications is achievable by primary perineal reconstruction using VRAM flap.


Subject(s)
Anus Neoplasms/mortality , Anus Neoplasms/surgery , Perineum/surgery , Plastic Surgery Procedures , Rectus Abdominis/transplantation , Surgical Flaps , Wound Healing , Adult , Aged , Aged, 80 and over , Anus Neoplasms/complications , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/surgery , Female , Follow-Up Studies , Humans , Male , Middle Aged , Neoplasm Recurrence, Local/diagnosis , Neoplasm Staging , Postoperative Complications/diagnosis , Postoperative Complications/therapy , Salvage Therapy , Survival Rate , Time Factors , Treatment Outcome
3.
Scand J Surg ; 95(3): 205-10, 2006.
Article in English | MEDLINE | ID: mdl-17066619

ABSTRACT

BACKGROUND: Growth hormone (GH) has been implicated as an important factor in the healing and previous studies showed significant strength acceleration of experimental intestinal anastomoses. AIM: To study the healing of experimental colonic anastomoses in GH-deficient rats and to study the potential physiological effects of GH-substitution on healing parameters. CONCLUSION: Exogenous rhGH treatment started 7 days prior to surgery and continued until day 4 postoperatively accelerates the strength development of the experimental colonic anastomoses in dwarf rats indicating a potent role of growth hormone in colonic healing. However, GH is not essential in the healing process, since anastomotic healing in GH-deficient dwarf rats is like rats with normal pituitary function.


Subject(s)
Colon/surgery , Dwarfism, Pituitary/metabolism , Growth Hormone/pharmacology , Recombinant Proteins/pharmacology , Wound Healing/drug effects , Anastomosis, Surgical , Animals , Colon/drug effects , Disease Models, Animal , Female , Rats , Rats, Inbred Lew
4.
Br J Plast Surg ; 56(4): 420-3, 2003 Jun.
Article in English | MEDLINE | ID: mdl-12873475

ABSTRACT

A 54-year-old male had a history of approximately 18 months, with a diagnostically proven squamous cell carcinoma of the lower left eyelid. The full-thickness subtotal defect was reconstructed with the Hughes procedure (tarsoconjunctival flap) combined with a subcutaneously based nasolabial flap for skin coverage. To our knowledge, the use of the subcutaneous based nasolabial flap in this context has not been described previously. Use of the nasolabial flap may be considered for eyelid reconstruction.


Subject(s)
Blepharoplasty/methods , Carcinoma, Squamous Cell/surgery , Eyelid Neoplasms/surgery , Surgical Flaps , Humans , Male , Middle Aged
5.
Br J Surg ; 90(5): 575-80, 2003 May.
Article in English | MEDLINE | ID: mdl-12734865

ABSTRACT

BACKGROUND: Perineal wounds following abdominoperineal resection (APR), for persistent or locally recurrent anal cancer, are associated with poor healing secondary to irradiation therapy. The results of APR combined with a vertical rectus abdominis musculocutaneous (VRAM) flap transposed transpelvically to cover the perineal defect are presented. METHODS: Between 1994 and 2000, 105 patients were diagnosed and treated for anal cancer. Twenty-two (21 per cent) underwent a salvage operation owing to persistent or locally recurrent disease. In eight patients, before 1996, the perineum was closed primarily with serious wound complications in five. In the final 14 patients, primary perineal reconstruction with a VRAM flap was performed. RESULTS: Median age was 65.5 (range 45-78) years. Median follow-up was 14.5 (range 3-41) months. There were no flap-related complications and primary healing was achieved in all patients. Median hospital stay was 17 (range 14-72) days. There were two major complications related to the laparotomy and abdominal closure. CONCLUSION: Combining the salvage operation with a VRAM flap facilitates primary healing after surgical treatment for persistent or locally recurrent anal cancer. A single-stage primary reconstructive procedure is feasible, with an acceptable complication rate and high level of patient satisfaction.


Subject(s)
Anus Neoplasms/surgery , Salvage Therapy , Surgical Flaps , Aged , Anus Neoplasms/drug therapy , Anus Neoplasms/radiotherapy , Female , Humans , Male , Middle Aged , Neoplasm Recurrence, Local , Neoplasm Staging , Patient Satisfaction , Postoperative Complications/etiology , Surgical Wound Dehiscence/etiology , Treatment Outcome , Urinary Incontinence, Stress/etiology , Wound Healing
6.
Kyobu Geka ; 56(4): 289-93, 2003 Apr.
Article in Japanese | MEDLINE | ID: mdl-12701191

ABSTRACT

Between July, 1988 and November, 2002, 108 patients underwent total cavopulmonary connection (TCPC) at Kobe Children's Hospital. The primary malformation was univentricular heart in 40 tricuspid atresia in 21, mitral atresia in 16, and other complex cardiac defects in the remaining 31. Fenestrated TCPC, staged TCPC, and off-pump TCPC were performed in 39, 26, and 15 high risk patients, respectively. Nitric oxide inhalation was administered in 46 patients. The mean follow-up period was 4.3 years (range, 1 month to 14 years). There were 10 early deaths due to low cardiac output syndrome in 4, thrombosis in 3, tracheal bleeding in 2, and disseminated intravascular coagulation in 1. There were 5 late deaths due to congestive heart failure in 2 patients, arrhythmia in 1, cerebral infarction in 1, and subarachnoid hemorrhage in 1. Late complications included arrhythmia in 17 patients, systemic desaturation caused by abnormal systemic venous channels in 10, pleural or pericardial effusion in 3, chylothorax in 1, and aortic valve incompetence in 1.


Subject(s)
Heart Bypass, Right/mortality , Heart Defects, Congenital/surgery , Adolescent , Child , Child, Preschool , Fontan Procedure , Heart Defects, Congenital/mortality , Humans , Infant , Risk Factors , Survival Rate
7.
Eur J Cardiothorac Surg ; 20(3): 598-602, 2001 Sep.
Article in English | MEDLINE | ID: mdl-11509285

ABSTRACT

OBJECTIVE: Among the later modifications of the Fontan type procedure, a significant alteration was introduced by de Leval and associates when they described the total cavopulmonary connection (TCPC). Although current results of TCPC have encouraged us to extend this procedure to high risk patients, risk factors influencing surgical outcome after TCPC have not been evaluated. We review our experiences with TCPC to identify which risk factors may have had a considerable impact on the outcome of patients undergoing TCPC and to clarify selection criteria of high-risk Fontan candidates for TCPC. PATIENTS AND METHODS: We retrospectively reviewed the medical and surgical records of all 76 patients who underwent TCPC between July 1988 and August 2000. A cross-sectional review of these patients was undertaken. RESULTS: There were eight early deaths and four late deaths. In a Fisher's exact test, the following variables were associated with an increased early mortality after TCPC: systemic ventricular morphology (right ventricle), ejection fraction of the systemic ventricle less than 60%, and prolonged cardiopulmonary bypass time (240 min or longer). The log-rank test demonstrated that heterotaxy syndrome, moderate to severe atrioventricular valve regurgitation, prolonged cardiopulmonary bypass time (240 min or longer), and prolonged aortic cross clamp time (70 min or longer) were associated with late mortality after TCPC. Six deaths occurred in eight (75%) patients who had six or more risk factors, whereas six deaths (9%) occurred in those who had five or fewer. CONCLUSIONS: Patients with complex cardiac anomalies who have six or more risk factors should be excluded from TCPC candidates.


Subject(s)
Heart Bypass, Right/mortality , Heart Defects, Congenital/surgery , Adolescent , Child , Child, Preschool , Heart Defects, Congenital/pathology , Heart Defects, Congenital/physiopathology , Humans , Infant , Retrospective Studies , Risk Factors
8.
Kyobu Geka ; 54(8 Suppl): 666-70, 2001 Jul.
Article in Japanese | MEDLINE | ID: mdl-11517529

ABSTRACT

Between October 1987 and December 2000, 50 patients underwent reconstruction of the pulmonary outflow tract without external conduit. The primary malformation was tetralogy of Fallot with pulmonary atresia in 37, double outlet of right ventricle in 4, corrected transposition of the great arteries in 4, transposition of the great arteries with ventricular septal defect and pulmonary stenosis in 4, and double outlet of left ventricle in 2. Mean age at operation was 7.2 years, and mean body weight was 18.3 kg. To reconstruct posterior wall of the pulmonary outflow tract, interposition of autologous pericardium was performed in 24, direct anastomosis between pulmonary trunk and ventriculotomy in 13, longitudinal incision from ventriculotomy through pulmonary trunk in 12, and interposition of left atrial appendage in 1. Anterior wall was reconstructed with monocusp valved outflow patch (MVOP). There was one hospital death and no late death. At 10 years, the freedom from reoperation for pulmonary outflow tract obstruction was 100%, and freedom from reoperation for any cause was 86.6%. Transcatheter stenting for peripheral pulmonary stenosis was performed in 6 patients 2 to 10 months after operation.


Subject(s)
Heart Defects, Congenital/surgery , Plastic Surgery Procedures/methods , Adolescent , Child , Child, Preschool , Heart Valve Prosthesis Implantation/methods , Heart Ventricles/surgery , Humans , Pulmonary Artery/surgery
9.
Org Lett ; 3(1): 37-40, 2001 Jan 11.
Article in English | MEDLINE | ID: mdl-11429865

ABSTRACT

[figure: see text] Kinetic measurements to determine effective molarities of intramolecular reactions using 2,4-pentanediol and related tethers showed that methyl groups on the tether accelerate the major diastereomeric process but decelerate the minor process. The efficient promotion of stereocontrol is suggested to be due to chiral perturbation of the reaction rate through the entropy term. The conformation of the encounter complex of the reagent and reactant moieties was deduced by stereochemical analysis of the intramolecular adducts.

10.
Chem Commun (Camb) ; (21): 2180-1, 2001 Nov 07.
Article in English | MEDLINE | ID: mdl-12240101

ABSTRACT

Hydroboration of conjugated dienes is promoted by the hydroxy and methoxy groups, which also control the rearrangement of the initially produced allylic boranes.

11.
Growth Horm IGF Res ; 10(2): 85-92, 2000 Apr.
Article in English | MEDLINE | ID: mdl-10931746

ABSTRACT

Growth hormone (GH) has been implicated as an important factor in the growth regulation of several visceral organs including the gastrointestinal tract. Our aim was to study the effects of GH administration on colonic growth in dwarf rats with an isolated GH deficiency. Dwarf rats were treated with recombinant human growth hormone (rhGH; 2.0 mg/kg/day) for four weeks and compared with saline treated dwarf rats and rats with normal pituitary function. The colonic wall composition was measured by means of stereological techniques. RhGH treatment of the dwarf rats increased body weight by 80% and proximal and distal colon weight by 63% and 90%, when compared with placebo treated dwarf rats (P< 0.01). The weight of the proximal colonic mucosa increased by 83% (P< 0.01), submucosa by 78% (P< 0.05), and the muscularis propria by 51% (P< 0.001) in rhGH treated dwarf rats compared with dwarf controls. The weight of the distal colonic mucosa increased by 88% (P< 0.01), submucosa by 88% (P< 0.05) and the muscularis propria by 58% (P< 0.05) compared with dwarf controls. The growth of mucosa involved all mucosal layers, with a 73 and 92% increase in the proximal and distal colon luminal surface area respectively (P< 0.001, P< 0.01). The food consumption, expressed as g/day/100 g BW was 13% higher in dwarf rats receiving rhGH than in placebo treated rats (P< 0.05) and normal control rats (P< 0.05). When weights of the GI tract compartments are corrected for the increase in body weight the effects of GH treatment were small or non-significant. RhGH administration in GH deficient dwarf rats induces visceral growth with a pronounced increase in colonic luminal surface area and growth of all layers of the colonic wall. These findings confirm the important role of GH in the regulation of intestinal growth.


Subject(s)
Colon/growth & development , Growth Hormone/deficiency , Human Growth Hormone/pharmacology , Animals , Blood Glucose/analysis , Blotting, Western , Body Weight/drug effects , Colon/drug effects , Eating/drug effects , Female , Human Growth Hormone/physiology , Insulin-Like Growth Factor Binding Proteins/blood , Insulin-Like Growth Factor I/metabolism , Intestinal Mucosa/drug effects , Ligands , Organ Size/drug effects , Radioimmunoassay , Rats , Rats, Inbred Lew , Recombinant Proteins/pharmacology , Time Factors
13.
Ann Thorac Surg ; 69(4): 1205-8, 2000 Apr.
Article in English | MEDLINE | ID: mdl-10800820

ABSTRACT

BACKGROUND: Accessory valve tissue is a rare congenital cardiac malformation causing a variety of clinical features. We describe our experience with the surgical treatment of accessory valve tissue to clarify clinical and pathological features of this anomaly. METHODS: Between December 1990 and February 1999, 11 children underwent resection of accessory valve tissue together with repair of coexisting intracardiac malformations. Eight patients had accessory tricuspid valve, while 3 had accessory mitral valve tissue. Associated intracardiac malformations included tetralogy of Fallot in 6 patients, transposition of the great arteries in 3, coarctation complex in 1, and ventricular septal defect in 1. RESULTS: Accessory valve tissue was completely resected in all but 1 patient with accessory mitral valve and transposition of the great arteries. As total resection of the accessory valve tissue through the pulmonary artery was unsuccessful, partial resection and bidirectional Glenn shunt operation was performed instead of arterial switch operation in this patient. CONCLUSIONS: The clinical signs and symptoms of accessory valve tissue vary according to its location and coexisting cardiac malformations. Congenital heart surgeons should be familiar with the clinical and pathological features of accessory valve tissue, so as not to overlook it during operation.


Subject(s)
Mitral Valve/abnormalities , Tricuspid Valve/abnormalities , Cardiac Catheterization , Child , Child, Preschool , Female , Heart Defects, Congenital/complications , Humans , Male , Mitral Valve/pathology , Transposition of Great Vessels/surgery , Tricuspid Valve/pathology
14.
Ann Thorac Surg ; 67(5): 1494-6, 1999 May.
Article in English | MEDLINE | ID: mdl-10355446

ABSTRACT

Because there are various types of systemic venous connections in patients with visceral heterotaxy, unanticipated abnormal systemic venous channels may pose additional problems after a Fontan type operation. We report a case of severe cyanosis caused by anomalous intrahepatic venovenous fistula to an accessory hepatic vein early after total cavopulmonary anastomosis.


Subject(s)
Cyanosis/etiology , Fontan Procedure , Hepatic Veins/abnormalities , Liver/blood supply , Postoperative Complications , Vascular Fistula/complications , Child , Fatal Outcome , Hepatic Veins/surgery , Humans , Ligation , Male , Oxygen/blood , Tricuspid Valve Insufficiency/surgery , Vascular Fistula/surgery
15.
J Thorac Cardiovasc Surg ; 118(1): 99-106, 1999 Jul.
Article in English | MEDLINE | ID: mdl-10384192

ABSTRACT

OBJECTIVES: We reviewed a 20-year experience with the surgical treatment of mitral valve disease in the pediatric age group at our institution with 2 objectives: to clarify the long-term results over the last 2 decades and to evaluate the recent advances in mitral valve operation in children. METHODS: Since December 1978, 56 patients have undergone a total of 36 mitral valve repairs and 30 mitral valve replacements. Associated cardiac anomalies were present in 46 patients (82%), and concurrent repair of associated lesions was performed in 37 patients (66%). The age of the patients ranged from 3 months to 15 years (mean, 3.6 years) at mitral valve repair, and ranged from 2 months to 16 years (mean, 5.7 years) at mitral valve replacement. Mean follow-up period was 92.0 months (range, 1-235 months). RESULTS: There were 2 hospital deaths and 2 late deaths in patients who underwent mitral valve repair. Reoperation was performed in 4 patients. Three of these patients underwent mitral valve replacement because of residual mitral incompetence. No hospital deaths occurred in patients who underwent mitral valve replacement. Two late deaths occurred after mitral valve replacement. Six patients had a total of 10 episodes of prosthetic valve thrombosis. Thrombolytic therapy with urokinase was successful in all episodes without serious complications. Five patients required reoperations 49 to 141 months (mean, 78.4 months) after the initial valve replacement for relative prosthetic valve obstruction as the result of somatic growth. A valve 2 or 3 sizes larger than the original prostheses was inserted without death. Actuarial survival and freedom from cardiac events at 10 years after the operation were 87.2% and 72.7% in children who underwent mitral valve repair, and 90.3% and 67.3% for those children who underwent mitral valve replacement. CONCLUSIONS: The current risk of mitral valve operation in the pediatric age group is low, and the long-term results are satisfactory, irrespective of severe deformation of the mitral valve apparatus and associated complex cardiac anomalies.


Subject(s)
Heart Valve Prosthesis Implantation , Mitral Valve Insufficiency/surgery , Mitral Valve Stenosis/surgery , Actuarial Analysis , Adolescent , Age Factors , Child , Child, Preschool , Disease-Free Survival , Follow-Up Studies , Heart Valve Prosthesis Implantation/adverse effects , Heart Valve Prosthesis Implantation/methods , Heart Valve Prosthesis Implantation/trends , Hospital Mortality , Humans , Mitral Valve , Mitral Valve Insufficiency/complications , Mitral Valve Stenosis/complications , Prosthesis Design , Reoperation/statistics & numerical data , Risk Factors , Thrombosis/drug therapy , Thrombosis/etiology , Treatment Outcome
16.
Kyobu Geka ; 52(4): 286-9, 1999 Apr.
Article in Japanese | MEDLINE | ID: mdl-10226420

ABSTRACT

From 1989, 4 patients underwent bilateral enlargement of the aortic valve ring for valve replacement. Age at the operation ranged from 2 to 8 (mean 6) years; body weight ranged from 14.9 to 25.4 (mean 19.0) kg. This procedure enabled us to implant a prosthesis 3 to 4 sizes larger (19 to 23 mm) than that measured with the native aortic annulus (13 to 17 mm). There was no late death and no cardiac event over a mean follow-up period of 6.2 years. Pressure gradient across the prosthesis measured by echocardiography was 40 mmHg in 1 patient who underwent aortic valve replacement with the use of 19 mm St. Jude Medical valve at 2 years of age. There was no significant pressure gradient in other 3 patients. All patients showed normal left ventricular function. We conclude that bilateral enlargement of the aortic valve ring for valve replacement has provided good midterm results with no mortality and no cardiac event.


Subject(s)
Aortic Valve Insufficiency/surgery , Aortic Valve/surgery , Heart Valve Prosthesis Implantation , Aortic Valve/pathology , Aortic Valve Stenosis/surgery , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Male , Ventricular Function, Left
17.
Kyobu Geka ; 52(2): 139-42, 1999 Feb.
Article in Japanese | MEDLINE | ID: mdl-10036875

ABSTRACT

A seven-year-old boy with tricuspid atresia successfully underwent a fenestrated total cavopulmonary connection and mitral valvuloplasty. Preoperative cardiac catheterization showed a mean pulmonary artery pressure of 16 mmHg. Pulmonary arteriography showed poor development of the branches (PA index: 180). Echocardiography revealed mild to moderate mitral valve incompetence due to prolapse of anterior leaflet. Mitral valve was exposed through the trans-septal approach. The excess chorda length was tucked into a longitudinal split in the top of the posterior papillary muscle. Then wedge resection of the redundant segment of the anterior leaflet and bilateral annuloplasty were performed. Finally, a total extracardiac cavopulmonary anastomosis with a 6 mm fenestration was completed. Postoperative clinical course was uneventful, and he is doing well with no recurrence of mitral incompetence 1 year after the operation.


Subject(s)
Fontan Procedure , Heart Bypass, Right/methods , Mitral Valve Insufficiency/surgery , Mitral Valve/surgery , Tricuspid Valve Insufficiency/surgery , Child , Humans , Male
18.
Surg Endosc ; 12(10): 1245-8, 1998 Oct.
Article in English | MEDLINE | ID: mdl-9745065

ABSTRACT

BACKGROUND: We evaluated a new aseptic method for laparoscopic left colon resection in terms of technical feasibility and outcome. METHODS: Ten pigs were operated on under general anesthesia. Pre- and postoperative body weight, stools, behavior, and need for analgesics were recorded. Fourteen days later, the animals were killed. At autopsy, the degree of intraabdominal adhesions was noted. The anastomoses were sent for histological examination. The entire procedure was performed intracorporeally, and no antibiotics were given. After division of the mesocolon, the segment to be resected was invaginated down through the colon. This was facilitated by a custom-made instrument that was introduced into the bowel via the anus; it consisted of a pull-out device and a modified diathermy wire. The anastomosis was completed at the invagination fold by a row of hernia staples that were covered by an interrupted suture. Then the invaginated bowel was transected by the diathermy wire and delivered through the anus. RESULTS: One animal was killed before completion of the operation because of a colonic perforation. The remaining nine animals had an uneventful and rapid recovery. They ate from the 1st postoperative day and gained weight rapidly. Stools were normal after 2 days (median), and normal behaviour was noted in all animals from the 1st postoperative day. At the postmortem examination, intraabdominal adhesions were observed in two animals. In one case, the adhesions extended from a hematoma in the mesentery to the abdominal wall. There were no adhesions to the anastomosis or the colon. In the other case, the anastomosis adhered to the right uterine tube and a loop of small intestines. CONCLUSIONS: The method is technically feasible, but a modification is suggested for cases where the invagination is impossible. Recovery after the operation is rapid.


Subject(s)
Anastomosis, Surgical/methods , Colectomy/methods , Laparoscopy/methods , Anastomosis, Surgical/adverse effects , Animals , Asepsis , Colon/pathology , Colon/surgery , Disease Models, Animal , Female , Laparoscopy/adverse effects , Sensitivity and Specificity , Swine
20.
Kyobu Geka ; 50(7): 577-9, 1997 Jul.
Article in Japanese | MEDLINE | ID: mdl-9223866

ABSTRACT

A 2-month-old female infant weighing 4.2 kg was admitted with severe congestive heart failure and respiratory distress. The patient was operated upon under a diagnosis of severe congenital mitral regurgitation and ventricular septal defect. There was thickening of the anterior leaflet and short thickened chordae. The valve was judged not amenable to repair and it was replaced with a 17 mm St. Jude Medical valve. She was extubated on the 5th postoperative day. Post operative anti-coagulant therapy was initiated with warfarin potassium, dipyridamole and ticlopidine hydrochloride. The postoperative course was uneventful and the patient is doing well 9 months after the operation.


Subject(s)
Heart Septal Defects, Ventricular/surgery , Heart Valve Prosthesis , Mitral Valve/surgery , Female , Humans , Infant , Mitral Valve Insufficiency/surgery
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