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Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) and the Risk of Developing Type 2 Diabetes.
Wittenbecher, Clemens; Ouni, Meriem; Kuxhaus, Olga; Jähnert, Markus; Gottmann, Pascal; Teichmann, Andrea; Meidtner, Karina; Kriebel, Jennifer; Grallert, Harald; Pischon, Tobias; Boeing, Heiner; Schulze, Matthias B; Schürmann, Annette.
Diabetes ; 68(1): 188-197, 2019 01.
Article in English | MEDLINE | ID: mdl-30396904

ABSTRACT

Recent studies suggest that insulin-like growth factor binding protein 2 (IGFBP-2) may protect against type 2 diabetes, but population-based human studies are scarce. We aimed to investigate the prospective association of circulating IGFBP-2 concentrations and of differential methylation in the IGFBP-2 gene with type 2 diabetes risk.


Subject(s)
Diabetes Mellitus, Type 2/blood , Insulin-Like Growth Factor Binding Protein 2/blood , Adult , Aged , Blood Glucose/metabolism , DNA Methylation/physiology , Female , Humans , Male , Middle Aged , Phenotype , Prospective Studies
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