ABSTRACT
INTRODUCTION: The EORTC Quality of Life (QL) Group has developed a questionnaire -the EORTC QLQ-CR29- for evaluating QL in colorectal cancer. The aim of this study is to assess the psychometric properties of the EORTC QLQCR29 when applied to a sample of Spanish patients. MATERIALS AND METHODS: Eighty-four locally advanced rectal cancer patients in the treatment follow-up period after receiving surgery and neoadjuvant chemoradiotherapy were included in the study. Seventy subjects also had adjuvant chemotherapy. Patients completed both the EORTC QLQC30 and the QLQ-CR29 once. The psychometric evaluation of the questionnaire's structure, reliability, and convergent, divergent and known-groups validity was performed. RESULTS: Multitrait scaling analysis showed that three of the multi-item scales met the standards of convergent and discriminant validity. These same scales reached the 0.7 Cronbach's coefficient criterion or were close to it. In both analyses exceptions were observed in the blood and mucus in stool scale. Correlations between the scales of the QLQC30 and the module were low (r<0.02) in most cases. A few areas with more related content had higher correlations (r<0.05). Group comparison analyses showed differences in QL between groups of patients based on age, comorbidity, performance status, receipt of adjuvant chemotherapy and surgery modality. CONCLUSIONS: The EORTC QLQ-CR29 is a reliable and valid instrument when applied to a sample of Spanish rectal cancer patients. These results are in line with those of the EORTC validation study (AU)
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Carcinoma/psychology , Carcinoma/therapy , Colorectal Neoplasms/psychology , Quality of Life , Colorectal Neoplasms/epidemiology , Carcinoma/rehabilitation , Colorectal Neoplasms/therapy , Colorectal Neoplasms/rehabilitation , Combined Modality Therapy/methods , Combined Modality Therapy/psychology , Surveys and Questionnaires , Social Class , Societies, Medical/organization & administration , Spain/epidemiology , Reproducibility of ResultsABSTRACT
Orbital metastases are a defined subgroup within ocular affection secondary to the distant spread of breast cancer. We review the published experience on the incidence of orbit extension from this type of tumour, with reference made to our experience as medical oncologists, together with the most common clinical features and the relevant aspects for imaging and histopathological diagnoses. The therapy for orbital metastases from breast cancer is included within the systemic therapy required by the distant spread of the disease, with some clinical benefits obtained from hormone therapy, chemotherapy and monoclonal antibodies. Palliative radiation and surgery may also play an important role in providing care to these patients. Although there are some published cases with long-term survival, the prognosis for these patients is poor, and new advances in knowledge and therapy are needed for this complication due to breast cancer.
Subject(s)
Breast Neoplasms/pathology , Orbital Neoplasms/secondary , Breast Neoplasms/therapy , Female , Humans , Orbital Neoplasms/epidemiology , Orbital Neoplasms/therapyABSTRACT
Las metástasis orbitarias representan una entidaddefinida dentro de la afectación ocular secundaria a ladiseminación a distancia del cáncer de mama. Se revisaen este trabajo la incidencia sobre la afectación orbitariaen este tipo de tumor, haciendo mención a nuestraexperiencia como oncólogos médicos, así como alas características clínicas más habituales y a los condicionantesque existen en el diagnóstico de imagen ehistopatológico.El tratamiento de las metástasis orbitarias del cáncerde mama queda incluido dentro de la terapia sistémicaque precisa la diseminación a distancia de laenfermedad, habiéndose obtenido beneficio de la hormonoterapia,quimioterapia y anticuerpos monoclonales.La radioterapia y la cirugía paliativa pueden tenertambién un papel importante en la atención a estaspacientes. Aunque existen casos de supervivencia alargo plazo, su pronóstico es malo, y se precisan nuevosavances en el conocimiento y tratamiento de estacomplicación del cáncer de mama
Orbital metastases are a defined subgroup withinocular affection secondary to the distant spread ofbreast cancer. We review the published experienceon the incidence of orbit extension from this type oftumour, with reference made to our experience asmedical oncologists, together with the most commonclinical features and the relevant aspects for imagingand histopathological diagnoses.The therapy for orbital metastases from breastcancer is included within the systemic therapyrequired by the distant spread of the disease, withsome clinical benefits obtained from hormonetherapy, chemotherapy and monoclonal antibodies.Palliative radiation and surgery may also play animportant role in providing care to these patients.Although there are some published cases with longtermsurvival, the prognosis for these patients ispoor, and new advances in knowledge and therapyare needed for this complication due to breastcancer
