Subject(s)
Magnetic Resonance Imaging , Uveitis/diagnosis , Uveomeningoencephalitic Syndrome/diagnosis , Administration, Oral , Adult , Chlorambucil/administration & dosage , Diagnosis, Differential , Female , Humans , Prednisone/administration & dosage , Tomography, X-Ray Computed , Triamcinolone Acetonide/administration & dosage , Uveomeningoencephalitic Syndrome/diagnostic imaging , Uveomeningoencephalitic Syndrome/drug therapyABSTRACT
Twenty-four eyes removed for complications of HSV keratitis were studied histopathologically. There were 20 men and 4 women with an average age of 61 years. Severe keratitis was seen in 14, moderate in 7, and mild in 3 eyes. Common features associated with severe keratitis were: acute perforation, granulomatous keratitis with giant cells in the stroma and Descemet's region, stromal inflammatory cells, angle-closure, severe iridocyclitis with diffuse or focal infiltration of lymphocytes and plasma cells, low-grade vitritis, choroiditis, and/or retinal periphlebitis. Specimens with moderate to mild keratitis had a similar distribution of inflammation but a lower incidence of granulomatous keratitis.
Subject(s)
Keratitis, Dendritic/pathology , Adult , Aged , Aged, 80 and over , Anterior Chamber/pathology , Choroiditis/pathology , Corneal Diseases/etiology , Corneal Diseases/pathology , Female , Glaucoma/etiology , Glaucoma/pathology , Granuloma/etiology , Granuloma/pathology , Humans , Iris/pathology , Keratitis, Dendritic/classification , Keratitis, Dendritic/complications , Male , Middle Aged , Retinal Diseases/etiology , Retinal Diseases/pathology , Retinal Vessels , Uveitis/etiology , Uveitis/pathologyABSTRACT
Experimental glaucoma was produced in one eye of five cynomolgus monkeys with the argon laser delivering 100-200 50-mu spots at 1200-1500 mW power and 0.5 sec to 360 degrees of the mid-trabecular meshwork. Monocular electroretinograms (ERGs) were recorded prior to and 2, 3, and 4 mo following the laser treatment. In the laser-treated (glaucoma) eyes, normal flash ERGs were observed using 1-Hz stimulation; however, pattern ERGs (PERGs) elicited using steady-state counterphase modulation of a 0.51 cpd square wave grating showed statistically significant reductions of amplitude. Only small reductions of PERG amplitude were seen with a 1.25 cpd grating. In three animals, abnormalities of the PERG occurred prior to clinically significant cupping of the optic nervehead. Moreover, reductions of PERG amplitude were progressive and associated with the magnitude of cupping of the optic nervehead and elevation of intraocular pressure. PERG amplitude did not change following acute reductions in intraocular pressure in the glaucoma eyes. Several control experiments were conducted to insure that results were not due to alterations in pupil size, refractive state, or accommodation in the glaucoma eyes. The authors believe they now have a monkey model for the electrophysiologic study of glaucoma.
Subject(s)
Electroretinography , Glaucoma/physiopathology , Animals , Female , Glaucoma/etiology , Lasers , Macaca fascicularis , Pattern Recognition, VisualABSTRACT
We compared the outflow facility coefficient results after indentation tonography obtained with a standard tonography unit and with a new computerized tonography machine. Goldmann applanation tonometry was followed by standard tonography on one eye and computerized tonography on the other. After a one-hour equilibration period, tonometry was repeated and followed by tonography with the testing units used on the opposite eyes. In nine of 60 eyes the results were discarded because of poor tracings or high error. Results of initial indentation intraocular pressure measured by the two units were not statistically different from those measured by Goldmann applanation tonometry. Mean outflow facilities determined by the standard unit and by the computerized machine with the average scleral rigidity program showed no statistically significant difference by the paired t-test.
