1.
Phytochemistry
; 131: 158-164, 2016 Nov.
Article
in English
| MEDLINE
| ID: mdl-27641672
ABSTRACT
To investigate bioactive compounds potentially involved in the biotic interactions exhibited by Phlomis purpurea (Lamiaceae) in rhizospheres infested with Phytophthora cinnamomi, the plant rhizome was chemically analysed. The nortriterpenoid (17S)-2α,3α,11α,23,24-pentahydroxy-19(18 â 17)-abeo-28-norolean-12-en-18-one, was isolated and its structure was elucidated by comprehensive spectroscopic analysis, chiefly using 2D NMR experiments, and X-ray analysis. It was shown to be exuded by roots and to exhibit anti-Phytophthora and antitumor activities.
Subject(s)
Antineoplastic Agents, Phytogenic/isolation & purification , Antineoplastic Agents, Phytogenic/pharmacology , Phlomis/chemistry , Phytophthora/drug effects , Triterpenes/isolation & purification , Triterpenes/pharmacology , Antineoplastic Agents, Phytogenic/chemistry , Drug Screening Assays, Antitumor , Glycosides/chemistry , HeLa Cells , Humans , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Plant Roots/chemistry , Portugal , Rhizome/chemistry , Triterpenes/chemistry
2.
Rev Port Cardiol
; 29(9): 1437-9, 2010 Sep.
Article
in Portuguese
| MEDLINE
| ID: mdl-21180186