1.
Acta Pol Pharm
; 55(3): 197-204, 1998.
Article
in English
| MEDLINE
| ID: mdl-9735700
ABSTRACT
Properties of a new crystalline beta-from of 1-acetoxyethyl ester of cefuroxime have been investigated and compared with known alpha-from and the amorphous form of this ester. Differences between these forms are discussed.
Subject(s)
Anti-Bacterial Agents/chemistry , Cefuroxime/analogs & derivatives , Cefuroxime/chemistry , Cephalosporins/chemistry , Anti-Bacterial Agents/pharmacokinetics , Biological Availability , Cefuroxime/pharmacokinetics , Crystallization , Gastric Juice/chemistry , Humans , In Vitro Techniques
2.
Acta Pol Pharm
; 52(6): 477-82, 1995.
Article
in English
| MEDLINE
| ID: mdl-8960266
ABSTRACT
Hydrolysis of 1-acetoxyethyl ester of cefuroxime [I] in blood was studied in vitro and in vivo. In vitro [I] hydrolyzes to biological active cefuroxime [II] and at the same time it undergoes isomerization to isomer delta 2 of 1-acetoxyethyl ester of cefuroxime [IV] and next hydrolyzes to biological inactive isomer delta 2 of cefuroxime [V]. As a result of hydrolysis [I] in vivo only [II] is formed.
