ABSTRACT
A method for the obtaining of increased viscosity (3.6-52.5 cP) eye drops, containing amikacin-aminoglycoside antibiotic and as increasing viscosity agents: polivinyl alkohol, hydroxyethylcellulose or sodium hyaluronate was elaborated. Physicochemical and biological properties of these eye drops were determined.
Subject(s)
Amikacin/administration & dosage , Anti-Bacterial Agents/administration & dosage , Amikacin/chemistry , Anti-Bacterial Agents/chemistry , Chemical Phenomena , Chemistry, Physical , Drug Compounding , Drug Stability , Indicators and Reagents , Ophthalmic Solutions , Preservatives, Pharmaceutical , ViscosityABSTRACT
A new method of isolation of cefetamet pivoxil, which results in higher purity and higher yield than according to the known methods, was worked out. The new method depends on ability to the adsorption on acidic active carbon of total amount of this antibiotic together with only a small amount of impurities. During two-step elution all impurities were washed out in the first step and in the next step pure cefetamet pivoxil was eluated by another solvent.
