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1.
J Eur Acad Dermatol Venereol ; 18(3): 337-9, 2004 May.
Article in English | MEDLINE | ID: mdl-15096149

ABSTRACT

Topical tretinoin is used in the treatment of acne and other dermatoses. The most common side-effects are itching, dryness and reddening of the skin. We report an additional cutaneous reaction, which occurred in patients using topical tretinoin. Pyogenic granulomas developed in two patients with acne and in one with dermatofibroma following application of tretinoin. The granulomas grew on the lesions after 2-3 weeks of therapy initiation. All patients were men and the granulomas developed in their trunk. The lesions resolved when topical tretinoin was ceased. Although the number of patients reported is too small to estimate the true incidence of this reaction, it is likely that dermatologists will encounter similar reactions in patients treated with topical tretinoin for acne or other reasons.


Subject(s)
Granuloma, Pyogenic/chemically induced , Granuloma, Pyogenic/pathology , Skin Diseases/chemically induced , Skin Diseases/pathology , Tretinoin/adverse effects , Acne Vulgaris/drug therapy , Administration, Topical , Adolescent , Adult , Biopsy, Needle , Humans , Immunohistochemistry , Keratolytic Agents/adverse effects , Keratolytic Agents/therapeutic use , Male , Prognosis , Risk Assessment , Sampling Studies , Severity of Illness Index , Tretinoin/therapeutic use
2.
Int J Clin Pharmacol Res ; 23(2-3): 41-6, 2003.
Article in English | MEDLINE | ID: mdl-15018017

ABSTRACT

In severe papulopustular and in nodulocystic/conglobate acne, oral isotretinoin is the treatment of choice. It is also required for patients with moderate to severe acne, especially when acne scars start to occur A new therapeutic approach consists of a low-dose regimen of isotretinoin. We performed a comparative study of high- and low-dose schemas of isotretinoin per os for the treatment of acne. The purpose of this study was to assess the therapeutic effect and tolerability of low doses of isotretinoin in the treatment of acne vulgaris and compare low-dose with high-dose regimens. Sixty-four patients (35 women and 29 men) with different types and grades of acne vulgaris were divided into two treatment groups of 32 patients, in a trial that compared a low dose of 0.15-0.40 mg/kg per day with a high dose of 0.5-1.0 mg/kg per day. These regimens were analyzed with reference to clinical history of acne, baseline investigations, dose and response to isotretinoin, clinical and laboratory adverse effects, relapses and cost of therapy. The mean success rate of the low-dose schema was 69%. The total dose up to 120 mg/kg should be followed for optimal results (success rate of 91%) and avoidance of relapses. The low-dose schema produced fewer adverse effects and offered a very beneficial effect on pre-existing scarring. Our results confirm the beneficial effect of the low-dose schema. We recommend a total dose > or = 120 mg/kg, as this therapeutic regimen of isotretinoin has proven to be the most successful in preventing relapses and scarring.


Subject(s)
Acne Vulgaris/drug therapy , Dermatologic Agents/therapeutic use , Isotretinoin/therapeutic use , Administration, Oral , Adolescent , Adult , Cost-Benefit Analysis , Dermatologic Agents/administration & dosage , Dermatologic Agents/adverse effects , Dermatologic Agents/economics , Dose-Response Relationship, Drug , Female , Humans , Isotretinoin/administration & dosage , Isotretinoin/adverse effects , Isotretinoin/economics , Male , Middle Aged , Recurrence , Treatment Outcome
3.
J Eur Acad Dermatol Venereol ; 14(1): 5-9, 2000 Jan.
Article in English | MEDLINE | ID: mdl-10877245

ABSTRACT

OBJECTIVE: A double-blind, single-site, split-face clinical study was organized and carried out in order to evaluate the efficacy, tolerability, and safety of a glycolic acid containing scalp lotion in conjunction with a betamethasone (as the 17-valerate) scalp application against conditions of psoriasis. BACKGROUND: Alpha-hydroxy acids (AHA) have been proposed as therapeutic modalities against skin exfoliative conditions such as ichthyosis, xeroderma, and psoriasis. AHAs are hereby clinically investigated as therapeutic modalities adjuvant to corticosteroids in order to diminish systemic and topical adverse side-effects most frequently associated with use of the latter. METHODS: Twenty patients suffering from scalp psoriasis and other psoriatic conditions were included in a double-blind, split-face clinical study, using combinations of a 10% (w/w) glycolic acid scalp lotion, placebo lotion (excipients only), and a 0.1% (w/w) betamethasone scalp application, applied twice daily without any bandage for a period of 8 weeks. Clinical assessments were carried out by highly experienced physician evaluations based on a four-grade scale, prior to treatment and after 2, 4, 6 and 8 weeks. RESULTS: Improvement was observed in all cases included in the study following treatment with the 10% glycolic acid lotion. However, when equal parts of the 0.1% betamethasone lotion were combined, most of the treated sites were healed. Moreover, the duration of treatment required for healing was in this case reduced to approximately half of that needed when the glycolic acid or the betamethasone lotions were used separately for treatment. CONCLUSIONS: The present clinical study demonstrates for the first time that the effective and well tolerated therapeutic efficacy of glycolic acid scalp lotions is enhanced when used in conjunction with a 0.1% betamethasone scalp application against scalp psoriasis. This potential offers the practising dermatologist with novel treatment modes against severe skin conditions by combining topical corticosteroid with exfoliative agent therapy.


Subject(s)
Anti-Inflammatory Agents/therapeutic use , Betamethasone Valerate/therapeutic use , Glycolates/therapeutic use , Lactic Acid/therapeutic use , Psoriasis/drug therapy , Scalp Dermatoses/drug therapy , Administration, Topical , Dosage Forms , Double-Blind Method , Drug Synergism , Glucocorticoids , Humans , Pharmaceutical Preparations
5.
Int J Dermatol ; 33(11): 803-7, 1994 Nov.
Article in English | MEDLINE | ID: mdl-7822089

ABSTRACT

BACKGROUND: Oral pemphigus is considered to represent either an initial stage of pemphigus vulgaris that should be treated with high doses of immunosuppressive drugs to prevent its spread to the skin or a variety of the disease that does not need aggressive treatment. The absence of a widely accepted therapeutic method and the obscure nature of this disease prompted this study. METHODS: Twenty-eight patients with oral pemphigus were randomly divided into three groups. The first group received only steroids at a dose of 40 mg of prednisone equivalent. In the other two groups the same dose of steroids was administered, but combined with either 100 mg of cyclophosphamide or 5 mg/kg of cyclosporine as an adjuvant. Direct immunofluorescence studies were performed on specimens obtained from both buccal mucosa and oral skin. RESULTS: There was no significant difference in the duration of treatment required to achieve remission and in the relapse rate among the three groups. The incidence of complications was higher with combination treatment. Deposited immunoreactants were detected with equal frequency in specimens obtained from the buccal mucosa and normal skin. CONCLUSIONS: Oral pemphigus most likely represents an initial stage of a disease that can become generalized. Administration of moderate doses of steroids alone is effective in controlling the disease.


Subject(s)
Cyclophosphamide/therapeutic use , Cyclosporine/therapeutic use , Mouth Diseases/drug therapy , Pemphigus/drug therapy , Prednisone/therapeutic use , Adult , Aged , Cyclophosphamide/administration & dosage , Cyclophosphamide/adverse effects , Cyclosporine/administration & dosage , Cyclosporine/adverse effects , Drug Combinations , Female , Fluorescent Antibody Technique , Follow-Up Studies , Humans , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Male , Middle Aged , Mouth Diseases/immunology , Mouth Diseases/pathology , Mouth Mucosa/pathology , Pemphigus/immunology , Pemphigus/pathology , Prednisone/administration & dosage , Prednisone/adverse effects , Recurrence , Remission Induction , Skin/pathology
7.
J Int Med Res ; 20(5): 392-400, 1992 Sep.
Article in English | MEDLINE | ID: mdl-1333423

ABSTRACT

A total of 40 patients with clinically and mycologically documented tinea corporis or tinea cruris were treated with 100 mg/day itraconazole (n = 19) or 500 mg/day griseofulvin (n = 21) for 15 days. Of the itraconazole-treated patients, 83.3% were healed or markedly improved, i.e. 'responders', after 15 days compared with 85.7% of griseofulvin-treated patients. At 15 days after the end of treatment, 88.2% of itraconazole- and 80.9% of griseofulvin-treated patients were classed as 'responders'. The mycological cure rate (both microscopy and culture negative) was generally lower than the clinical response rate. Both treatments were equally effective at the end of 15 days' treatment with 66.7% of patients cured, but itraconazole was superior to griseofulvin at the 15-day follow-up visit (77.8% of itraconazole-treated patients compared with 66.7% of griseofulvin-treated patients were cured). Both therapies were well tolerated; only one patient treated with itraconazole reported minor side-effects (dizziness, headache and gastro-intestinal disturbances). The results confirm those of earlier comparative trials and suggest that griseofulvin-treated patients are more at risk of relapse than are itraconazole-treated patients.


Subject(s)
Antifungal Agents/therapeutic use , Griseofulvin/therapeutic use , Ketoconazole/analogs & derivatives , Tinea/drug therapy , Adolescent , Adult , Aged , Double-Blind Method , Female , Humans , Itraconazole , Ketoconazole/therapeutic use , Male , Middle Aged , Species Specificity , Tinea/microbiology , Trichophyton/isolation & purification
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