ABSTRACT
This study assessed the effect of coronary artery bypass grafting (CABG) on myocardial systolic functions using tissue Doppler imaging (TDI). Fourteen patients (three women and 11 men) who had undergone isolated coronary bypass surgery were included in the study. Their mean age was 61 +/- 8 years. TDI systolic velocity measures were obtained from four different sites on the left ventricular wall (anterior, septal, lateral and inferior) at the papillary muscle level in the parasternal short axis view before CABG, and then at 1 and 6 weeks post-operatively. There were significant increases in the myocardial wall velocities at all left ventricular sites 1 week after CABG. This increase persisted to week 6 after CABG, but the velocities were lower than week 1 values. We conclude that the ischaemic myocardium responded to surgical revascularization with marked increases in myocardial segmental systolic velocities in the early post-operative period.
Subject(s)
Coronary Artery Bypass , Coronary Vessels/diagnostic imaging , Diagnostic Imaging , Heart/physiology , Systole/physiology , Female , Humans , Male , Middle Aged , UltrasonographyABSTRACT
BACKGROUND: Although 5-fluorouracil (5-FU)-related cardiotoxicity is well known, atrial arrhythmia, as a potentially serious complication has not been studied in detail. The aim of this study was to determine the P max and Pd in the electrocardiograms (ECG) of patients receiving 5-FU treatment. METHODS: Twenty-five patients (mean age: 62 years) receiving a 5-FU bolus plus continuous infusion with calcium leucovorin over 48 h and with normal pre-treatment cardiac physical examinations, ECG and echocardiography were enrolled. P maximum (P max), P minimum (P min) and P dispersion (Pd) (maximum minus minimum P wave duration) were measured from the 12-lead ECG at the 0th and 48th hour of the first chemotherapy cycle. Echocardiography was also obtained in all patients at the same times. RESULTS: Clinical cardiotoxicity was observed in two patients. P max and Pd were both significantly longer after 5-FU treatment at the 48th hour (P < 0.001). P min did not change (P > 0.05). CONCLUSION: Treatment with 5-FU based regimens may increase Pd and prolong the P max in cancer patients. These alterations may be predictive of patients at risk of atrial arrhythmias during 5-FU treatment.
Subject(s)
Electrocardiography/drug effects , Fluorouracil/therapeutic use , Leucovorin/therapeutic use , Aged , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/pharmacology , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoid Tumor/complications , Carcinoid Tumor/diagnosis , Carcinoid Tumor/drug therapy , Carcinoma/complications , Carcinoma/diagnosis , Carcinoma/drug therapy , Colorectal Neoplasms/complications , Colorectal Neoplasms/diagnosis , Colorectal Neoplasms/drug therapy , Coronary Artery Disease/complications , Coronary Artery Disease/diagnosis , Coronary Artery Disease/drug therapy , Coronary Vasospasm/chemically induced , Coronary Vessels/drug effects , Dose-Response Relationship, Drug , Drug Administration Schedule , Echocardiography/methods , Electrocardiography/methods , Female , Fluorouracil/administration & dosage , Fluorouracil/adverse effects , Humans , Infusions, Intravenous , Injections, Intravenous , Leucovorin/administration & dosage , Leucovorin/adverse effects , Male , Stomach Neoplasms/complications , Stomach Neoplasms/diagnosis , Stomach Neoplasms/drug therapy , Time FactorsABSTRACT
We described here a patient envenomated by a bee sting that caused myocardial damage compatible with non-ST elevation acute myocardial infarction. She developed a typical course of myocardial infarction; the ECG changes were reversed to almost all normal limits. She had normal coronary angiography and reversible wall motion abnormalities. Myocardial damage following prolonged spasm in the coronary arteries may be the underlying factor.
Subject(s)
Bee Venoms/adverse effects , Bees , Insect Bites and Stings/complications , Myocardial Infarction/etiology , Adult , Animals , Coronary Angiography , Electrocardiography , Female , Humans , Myocardial Infarction/diagnosisABSTRACT
Behçet's disease is a chronic multi-system disease presenting with recurrent oral and genital ulceration, and relapsing uveitis. Cardiac involvement is an extremely rare manifestation of this disorder. We report an unusual case of Behçet's disease characterized by a mural cardiac thrombi in the right atrium and right ventricle along with transient protein C and S deficiency.
