ABSTRACT
The level of medium molecular peptides (MMP) grows up in blood plasma of patients with diabetes mellitus (DM), which results in endogenous intoxication. The MMP concentration is high in patients with insulin-independent DM at compensation and without renal affection versus insulin-dependent DM, which is explained by presence of 1-3 kDa peptides. An aggravated course of DM including subcompensation is associated with a higher MMP level in patients with both DM types. The onset of the initial stage of diabetic nephropathy brings about an essential decrease of all MMP fractions in both DM types.
Subject(s)
Diabetes Mellitus, Type 1/metabolism , Diabetes Mellitus, Type 2/metabolism , Insulin/metabolism , Peptides/blood , Blood Glucose/analysis , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 2/complications , Diabetic Nephropathies/etiology , Diabetic Nephropathies/metabolism , Humans , Molecular Weight , Peptides/chemistry , Protein BindingABSTRACT
The concentration of mean molecule peptides is by far less in serum versus plasma. The concentration of mean molecule peptides in serum can go down, in endotoxicosis degrees 3-4, to normal values, whereas it can exceed 3-4-fold the normal value in plasma. The most pronounced reduction of peptides' concentration in serum was registered for the fraction with the molecular weight ranging from 800 to 3000 D.
