ABSTRACT
Kikuchi's lymphadenitis (KL; histiocytic necrotizing lymphadenitis without granulocytic infiltration) is a generally benign, febrile disorder of unknown aetiology with distinct histological features. To date, a minority of cases reported have been associated with infectious agents. A typical pathological case of KL is described where involvement of Yersinia enterocolitica was shown by an indirect immunofluorescent assay applied to lymphatic tissue. The case is discussed with emphasis on recent insight into the course and aetiology of KL.
Subject(s)
Lymphadenitis/microbiology , Yersinia Infections/microbiology , Yersinia enterocolitica/isolation & purification , Adult , Fluorescent Antibody Technique , Humans , Lymph Nodes/microbiology , Lymph Nodes/pathology , Lymphadenitis/pathology , Male , Necrosis , Yersinia Infections/pathologyABSTRACT
Familial Mediterranean fever, a genetic disorder with an autosomal recessive pattern of inheritance, occurs in patients originating from the eastern Mediterranean. Characteristic features are attacks of fever, peritonitis, pleuritis, synovitis and skin rash. The disease may be complicated by amyloidosis. Treatment with colchicine is generally successful.
Subject(s)
Familial Mediterranean Fever/diagnosis , Abdomen, Acute/diagnosis , Adult , Colchicine/therapeutic use , Diagnosis, Differential , Familial Mediterranean Fever/drug therapy , Familial Mediterranean Fever/ethnology , Humans , Male , Netherlands , Turkey/ethnologyABSTRACT
A 53-year-old woman with reversible bone marrow insufficiency caused by aminoglutethimide (AGT) treatment of metastatic breast carcinoma is described. The clinical picture included moderate thrombocytopenia and severe granulocytopenia complicated by Gram-positive septicaemia and skin infections, and by oral candidiasis. Withdrawal of AGT and antibiotic therapy resulted in clinical and haematological recovery, but the patient died suddenly, probably from a cardiac cause. Autopsy revealed widespread bone metastases, but no bone marrow infiltration of breast carcinoma. The haematological hazards caused by application of AGT are discussed.