[Use of a combined epidemiological, virological and morphological analysis of rubella infection for an epidemiological survey of congenital rubella]. / Primenenie kompleksnogo épidemiologicheskogo i virusologo-morfologicheskogo analiza krasnushknoi infektsii v tseliakh épidemiologicheskogo nadzora za vrozhdennoi krasnukhoi.

The results of composite epidemiological, virological and morphological studies of intrauterine rubella infection performed in 1979, in the period of maximum increase of rubella incidence in Moscow for 11 years (1969-1979) are presented. Investigations of 125 foci of rubella established a relatively high frequency of contacts of pregnant women with the source of infection in families of rubella patients. Twenty-nine cases of clinically manifest and inapparent rubella among pregnant women were detected and confirmed in the laboratory; intrauterine infection at 3-17 weeks was established in 16 out of 18 virologically examined women. The ratio of the disease forms was 3.5 : 1. Using laboratory methods of investigations, rubella of pregnant women was confirmed in 100% cases. From the aborted and fetal materials collected in the disease or inapparent infections of pregnant women rubella virus was isolated in 88.9%, marked pathomorphological lesions were found in organs of 61% of the fetuses examined. The organotropism of rubella virus was confirmed by a high rate (87%) of virus isolation from placenta and umbilical cords as well as by localization of morphological lesions in these organs and in the eye lens tissues. These characteristics of marked teratogenic potentials of the circulating virus strains indicate the necessity of organization of regular epidemiological surveys of rubella in pregnant women for prevention of congenital rubella in the USSR.

[Experience with registration of purulent-septic diseases in newborn infants]. / Opyt registratsii gnoino-septicheskikh zabolevanii u novorozhdennykh detei.

The recording or urgent reports in Moscow since 1974 allowed analyzing the cases of purulent and septic diseases for the period of 1974-1978. The features of the time course and morbidity pattern of the disease, its seasonal fluctuations and the time of onset are presented. Thus, a tendency towards a decrease in morbidity was noted during the above period. The leading role of the diseases of the skin and the subcutaneous fat was established, the morbidity reports were found to fall mostly on the first 2 weeks of the infants' life, and the morbidity rate varied in different maternity hospitals. The recording ensured obtaining current data on morbidity, thus allowing forecast and prevention of the disease.

[Reactogenicity and immunologic activity of live enteric Sonne dysentery vaccine from a spontaneous mutant]. / Reaktogennost' i immunologicheskaia aktivnost' zhivoi énteral'noi dizenteriinoi vaktsiny zonne iz spontannogo mutanta

Live dysentery Sonne vaccine from a spontaneous mutant proved to be practically areactogenic and specifically harmless in oral immunization of children aged from 7 to 13 years, in doses of from 3 to 25 milliard live microbial cells and in single and triple immunization schemes. Weak reactions of the gastro-intestinal tract were noted with the same frequency (1.7%) in children immunized with the vaccine and in children given placebo (2.2%). There proved to be a significant increase in the serum of the immunized persons of the level of specific hemagglutinins, and also of the IgA-and IgM-titers in 82% of the persons vaccinated; they persisted at a high level for 2 months. The appearance of IgA-antibodies in high titres in the persons vaccinated orally pointed to a marked local and general immunological activity of the live dysentery Sonne vaccine from the spontaneous mutant processing the capacity to survive in the intestine of children for a long time.

[Study of the virulence of Shigella sonnei isolated from persons with different forms of dysenteric infection]. / Izuchenie virulentnosti shigell Zonne, vydelennykh ot lits s razlichnymi formami dizenteriinoi infektsii

Possible ranges of virulence of Sh. sonnei strains isolated from the patients and carriers in the foci of Sonne dysentery, supposedly with the same source of infection, were studied. Sh. sonnei strains isolated from carriers proved to be less virulent than the strains isolated from patients with the clinical manifestation of the infection. A hypothesis was put forward explaining some aspects of carrier state in Sonne dysentery, which most probably was explained by the refracterity of the macroorganism, not by the alterations in the genom of the causative agent.

[Results of a controlled epidemiological trial of the application of placental gamma globulin in foci of meningococcal infection]. / Itogi kontroliruemogo épidemiologicheskogo opyta po primeneniiu platsentarnogo gamma-globulina v ochagakh meningokokkovoi infektsii

Controlled epidemiological trial was applied to the study of the use of placental gamma-globulin for prophylaxis of generalized forms of meningococcus infection in the foci (creches and kindergartens). A group of the vaccinated children (16 140) and control group (16 080) were the same age and sex. Gamma-globulin was administered in a dose of 3 ml to every other child attending creches and kindergartens not later than the 10th day after the patient's isolation. It was shown that the efficacy coefficient of gamma-globulin in the foci of meningococcus infection constituted 68% (the efficacy index was 3.2) for one month after the administration.