[Effect of phenazepam in various medicinal forms on psychophysical state of patients with anxiety disorders].

Differences between phenazepam formulations were found in the clinical study of drug effects on the psychophysiological state in patients with anxiety disorder. Phenazepam did not cause negative changes of psychophysiological parameters. In patients with anxiety disorders, the most significant positive therapeutic actionon psychophysiological state was observed in the case of using transdermal phenazepam formulation.

[Clinical and electroencephalographic characteristic of noopept in patients with mild cognitive impairment of posttraumatic and vascular origin].

An effect of a new nootropic drug noopept on the dynamics of main EEG rhythms and narrow-band spectral EEG characteristics in patients with cerebral asthenic and cognitive disturbances caused by traumas or vascular brain diseases has been studied. Noopept caused the EEG changes characteristic of the action of nootropics: the increase of alpha- and beta-rhythms power and reduction of delta-rhythms power. The reaction of alpha-rhythm was provided mostly by the dynamics of its low and medium frequencies (6,7-10,2 Hz), the changes of beta-rhythm were augmented in frontal and attenuated in occipital areas. The analysis of frequency and spatial structure of EEG changes reveals that noopept exerts a nonspecific activation and anxyolytic effect. The differences in EEG changes depending on the brain pathology were found. The EEG indices of nootropic effect of the drug were most obvious in cerebral vascular diseases. The EEG changes in posttraumatic brain lesion were less typical.

[Pilot clinical trial of ladasten].

The psychotropic actibn and efficacy of ladasten, a new psychostimulant with anxiolitic activity, was studied in a standard clinical trial involving therapy of patients with psychogenic asthenic disorder. Ladasten exhibits a unique combination of therapeutically significant stimulant and anxiolytic effects, which is unusual of psychostimulants. At the same time, the results of ladasten action upon single administration on the dynamics of psychopatological disorders and psychological self-test indexes show that the psychostimulant action is predominating. The established combination of the psychostimulant and anxiolytic effects of ladasten is optimal for the therapy of patients with psychogenic asthenic disorders. Ladasten shows high efficacy in the treatment of these disorders testify and has good prospects for practical application.

[Effect of tanakan on psychophysiological status of patients with asthenic disorders]. / Vliianie tanakana na psikhofiziologicheskoe sostoianie bol'nykh s astenicheskimi rasstroistvami.

A clinical pharmacological 56-day trial was devoted to the effect of tanakan on the psychophysiological state of 26 patients with psychogenic and post-traumatic asthenic disorders. The drug was found to produce a positive effect on the psychophysiological state, with most pronounced improvement in the attention characteristics, short-term visual memory, operational component, and integral operator performance index. The results confirmed the positive action of tanakan on the cognitive and mnestic functions, which is analogous to the effect of nootropes. The antiasthenic, anxiolytic, antiamnesic, and vegetotropic components in the pharmacological spectrum of tanakan correlate with the positive psychophysiological effects. It is shown that positive changes in the psychophysiological state play an important role in the complex therapeutic action of tanakan in the treatment of asthenic disorders.

[Therapeutic action and efficiency of fevarin (fluvoxamine) in patients with non-psychotic anxious and apathic-adynamic depressions]. / Terapevticheskoe deistvie i éffektivnost' fevarina (fluvoksamina) u bol'nykh s nepsikhicheskimi trevozhnymi i apatoadinamicheskimi depressiiami.

10 patients with anxious and 10 patients with apathic-adynamic depressions were treated with fevarin. The efficiency of the drug and its influence on the psychopathologic structure were evaluated according to some scales. It was established that therapeutic action of fevarin manifests from the 1st week of therapy in patients with anxious depressions due to its anxiolytic properties. In apathic-adynamic depressions the reduction of the symptoms was revealed by the 3-4 week of the therapy. The antidepressive effect of fevarin was retarded and didn't depend on the structure of the depression. Higher efficiency of the drug in patients with anxious depressions was explained by combination of thymoanaleptic and anxiolytic effects. The results of the study demonstrate a perspective of fevarin in therapy of anxious and apathic-adynamic depressions.

[Relation between mexidol glucuronide conjugation and characteristics of its therapeutic effect in patients with organic lesions in the central nervous system]. / Vzaimosviaz' gliukuronokon''ugatsii meksidola i osobennostei ego terapevticheskogo deistviia u bol'nykh s organicheskim porazheniem TsNS]

The clinico-pharmacological and pharmacokinetic investigation of mexidole administered in patients with organic CNS damage showed for the first time that there is a correlation between intensity of the drug--glucurone conjugation and the parameters of psychopathological symptom expression and the individual patient state estimation before treatment and upon a single administration or a course of mexidole therapy. This correlation allows the clinico-pharmacological effects and the therapeutic efficacy of mexidole to be predicted based on the drug metabolism index.

["Fast" and "slow" components of psychotropic activity of the drugs with nootropic effects]. / "Bystrye" i "medlennye" komponenty psikhotropnogo deistviia preparatov s nootropnymi svoistvami.

A clinical-pharmacological study was carried out to evaluate correlation of "fast" (nonspecific) and "slow" (specific) components of the action of the drugs with nootropic properties (piracetam, mexidol, tanacan) and to estimate their contribution to achieving therapeutic efficacy. The study was performed during 28 days using standard quantitative assay techniques in 79 patients with "Organic emotional-liable (asthenic) disorders" (F06.6, ICD-10). It was found that "fast" component of the psychotropic action of the drugs tested was presented by stimulating and anxiolytic effects, while a "slow" one--by specific nootropic activity. All these effects were fully independent with no correlation found, and this could, probably, be attributed to different mechanisms of their realization. It is shown that nootropic activity of piracetam was most significant in its therapeutic effect; and anxiolytic effect was most important for mexidol action. Meanwhile, stimulating and anxiolytic activities as well as positive influence on long-term memory were main components of tanacan effect. The results obtained show an important role of both specific and nonspecific ("fast") effects in realization of therapeutic action of the drugs with nootropic effects in patients with cognitive-mnestic and neurosis-like disorders.

[The therapeutic efficacy and the effect of gidazepam and fenazepam on the psychophysiological status and on the performance of operators with mental disorders at a neurotic level]. / Terapevticheskaia éffektivnost' i vliianie gidazepama i fenazepama na psikhofiziologicheskoe sostoianie i rezul'tativnost' deiatel'nosti operatorov s psikhicheskimi narusheniiami nevroticheskogo urovnia.

The effect of placebo and gidazepam on the state, psychophysiological predictors of the quality of the operator's performance and its results in individuals with neurotic reactions was studied (test dose 20 mg 7-day course, 40 mg daily, 24 individuals), as well as the effect of gidazepam and phenazepam (42 individuals with neurotic and neurosis-like states; gidazepam test doses 20 and 50 mg, 14-day course, 40 and 100 mg daily; phenazepam test doses 0.5 and 1 mg, 14-day course, daily dose 2 mg). The generally accepted methods of clinical and psychophysiological examination were applied. Gidazepam in the doses under study did not yield to phenazepam in therapeutic activity. A single and a course administration of gidazepam improved the parameters of the psychophysiological state and the efficacy of the operator performance in patients with neurotic reactions and in those with neurotic and neurosis-like states. This makes it possible, whenever necessary, to recommend this drug for the treatment of the indicated disorders in the working operators.

[Clinico-epidemiological characteristics of the ambulatory group of elderly patients with endogenous affective psychoses]. / Kliniko-épidemiologicheskaia kharakteristika dispansernogo kontingenta bol'nykh éndogennymi affektivnymi psikhozami pozdnego vozrasta.

The studies were carried out on the basis of the Gerontopsychiatry Center servicing patients aged 60 and more years in one of the districts of Moscow. 163 persons suffering from endogenous affective diseases were identified. The disease prevalence was 3.75 per 1000 population and the incidence 32.2 per 100,000 population. The data were obtained, indicating the rise of the disease prevalence and incidence with age (mainly at the expense of women). In the majority of patients (71.8%), different psychopathological disturbances were detected. 37.4% manifested affective disorders within the structure of the successive disease attack. The number of inpatients was only 4.3%. These data point to the necessity of the development of outpatient specialized forms of gerontopsychiatric assistance.