ABSTRACT
A 54-year-old female patient with a history of acute myeloid leukaemia and receiving maintenance chemotherapy had a systemic relapse. She also had candidaemia caused by Candida tropicalis. Her blood cultures were negative after receiving antifungal treatment. Later, she had an ophthalmological assessment as part of the protocol, without ocular discomfort. In the fundoscopic examination, a whitish chorioretinal lesion was found in the left eye in relation to subretinal abscess, which correlated with retinal angiography and optical coherence tomography. The patient was treated with systemic antifungals with a favourable resolution of the lesion.
Subject(s)
Candida tropicalis , Leukemia, Myeloid, Acute , Abscess/diagnosis , Abscess/drug therapy , Antifungal Agents/therapeutic use , Female , Humans , Leukemia, Myeloid, Acute/complications , Leukemia, Myeloid, Acute/drug therapy , Middle Aged , Neoplasm Recurrence, LocalABSTRACT
Paciente mujer de 54 años con historia de leucemia mieloide aguda, bajo quimioterapia de mantenimiento, cursa con recaída sistémica y candidemia por Candida tropicalis (C. tropicalis), tratada con antifúngico, con respuesta favorable es referida a oftalmológica como parte de protocolo. El examen fundoscópico en ojo izquierdo halló una lesión blanquecina, coriorretiniana en el cuadrante súpero temporal. Los exámenes de angiografía retinal y tomografía de coherencia óptica correlacionaron con absceso subretinal. La paciente fue tratada con antifúngicos sistémicos con resolución favorable de la lesión. Los abscesos subretinianos son una rara manifestación intraocular por C. tropicalis, este organismo es potencial agente causal de afección ocular en presencia de antecedente sistémico de inmunosupresión y factores de riesgo asociados.
A 54-year-old female patient with a history of acute myeloid leukaemia and receiving maintenance chemotherapy had a systemic relapse. She also had candidaemia caused by Candida tropicalis. Her blood cultures were negative after receiving antifungal treatment. Later, she had an ophthalmological assessment as part of the protocol, without ocular discomfort. In the fundoscopic examination, a whitish chorioretinal lesion was found in the left eye in relation to subretinal abscess, which correlated with retinal angiography and optical coherence tomography. The patient was treated with systemic antifungals with a favourable resolution of the lesion.
Subject(s)
Humans , Female , Middle Aged , Health Sciences , Ophthalmology , Abscess , Retinal Diseases , Candida tropicalis , Leukemia, MyeloidABSTRACT
A 54-year-old female patient with a history of acute myeloid leukaemia and receiving maintenance chemotherapy had a systemic relapse. She also had candidaemia caused by Candida tropicalis. Her blood cultures were negative after receiving antifungal treatment. Later, she had an ophthalmological assessment as part of the protocol, without ocular discomfort. In the fundoscopic examination, a whitish chorioretinal lesion was found in the left eye in relation to subretinal abscess, which correlated with retinal angiography and optical coherence tomography. The patient was treated with systemic antifungals with a favourable resolution of the lesion.
ABSTRACT
Twenty five percent of orbital metastasis is usually of unknown primary origin and it requires histopathological and immunohistochemical confirmation. The fine-needle aspiration biopsy of the orbit is an alternative procedure to conventional orbitotomy. The case is presented of a 60 year-old woman with a right orbit tumour mass and neoplastic lesions in her brain and cranium. As an incidental finding, she had a thrombus in her left atrium, and so an orbitotomy procedure was ruled out. An ultrasound-guided fine-needle aspiration biopsy was performed instead with rapid on-site evaluation of biopsy samples. These showed malignant cells of a lung adenocarcinoma, which was confirmed with immunohistochemistry and chest diagnostic images. In conclusion, biopsy samples obtained by fine-needle aspiration biopsy, together with cytopathological and immunohistological analysis, enabled orbital metastasis to be identified in the case described, and showed that fine-needle aspiration biopsy is a safe, effective, and minimally invasive alternative.
Subject(s)
Adenocarcinoma/secondary , Endoscopic Ultrasound-Guided Fine Needle Aspiration , Lung Neoplasms/pathology , Orbital Neoplasms/secondary , Adenocarcinoma/diagnostic imaging , Adenocarcinoma/pathology , Female , Humans , Middle Aged , Orbital Neoplasms/diagnostic imaging , Orbital Neoplasms/pathologyABSTRACT
CASE REPORT: A 35 year-old male patient with a history of HIV infection characterized by progressive tumour growth in bulbar conjunctiva of the left eye, corresponding to conjunctival squamous cell carcinoma that responded to treatment with interferon alpha-2a. DISCUSSION: Interferon alpha-2b has been used at conjunctival level as a topical immunomodulator treatment, with complete remission of epithelial neoplasms being observed. However, there have not been any previous publications on the use of interferon alpha-2a, which differs from interferon alpha-2b in a single amino acid, for the treatment of conjunctival squamous cell carcinoma.
