1.
Med Pediatr Oncol
; 22(3): 208-10, 1994.
Article
in English
| MEDLINE
| ID: mdl-8272012
ABSTRACT
We report the case of a 8-month-old girl who presented with a metastatic malignant germ cell tumor (MGCT) that proved to be resistant to chemotherapy, including salvage platinum-based combination therapy, surgery, and metastatectomy. The child was then treated with high-dose carboplatin, etoposide, and cyclophosphamide with autologous bone marrow rescue (ABMR) for two courses, since the first course was well tolerated and resulted in serum alpha-f etoprotein normalisation. The child remains in complete remission 3 years post-ABMR and 4 years post-diagnosis, with no detectable treatment-related sequelae. Thus, as already reported in adults, dose-intensive chemotherapy with ABMR may have curative potential in children with refractory MGCT.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bone Marrow Transplantation , Germinoma/secondary , Germinoma/therapy , Pelvic Neoplasms/therapy , Salvage Therapy , Bone Neoplasms/secondary , Cisplatin/administration & dosage , Combined Modality Therapy , Drug Resistance , Female , Humans , Ifosfamide/administration & dosage , Infant , Liver Neoplasms/secondary , Neoplasm Recurrence, Local/therapy , Pelvic Neoplasms/pathology , Recurrence , Remission Induction , Sacrococcygeal Region/pathology
2.
Pediatr Pulmonol
; 16(2): 138-40, 1993 Aug.
Article
in English
| MEDLINE
| ID: mdl-8367220