1.
Ecotoxicol Environ Saf
; 64(3): 362-8, 2006 Jul.
Article
in English
| MEDLINE
| ID: mdl-15949845
ABSTRACT
White sturgeon (Acipencer transmontanus) were exposed to 7.2 microM (1.0 ppm) 14C-labeled p-nitrophenol (PNP) in brackish water for 24 h and then allowed to depurate in clean brackish water for another 24h. Absorption, conditional uptake clearance, and conditional elimination rate constants were 0.08+/-0.04 h(-1), 8.1+/-3.6 mL g(-1) h(-1), and 0.46+/-0.21 h(-1), respectively. A whole-organism total concentration factor of 18.7+/-2.6 was determined from equilibrium tissue and water concentrations. Sturgeon depurated 89.4% of absorbed PNP within 24h, of which 53.0+/-8.3% was unmetabolized parent compound, 9.6+/-3.6% was p-nitrophenyl-beta-d-glucuronide, and 39.1+/-8.3% was p-nitrophenylsulfate.
Subject(s)
Fishes/metabolism , Nitrophenols/pharmacokinetics , Nitrophenols/toxicity , Water Pollutants, Chemical/pharmacokinetics , Water Pollutants, Chemical/toxicity , Animals , Biotransformation , Motor Activity/drug effects , Nitrophenols/analysis , Toxicity Tests , Water Pollutants, Chemical/analysis
2.
Bull Environ Contam Toxicol
; 73(1): 213-8, 2004 Jul.
Article
in English
| MEDLINE
| ID: mdl-15386094
3.
Bull Environ Contam Toxicol
; 73(3): 448-56, 2004 Sep.
Article
in English
| MEDLINE
| ID: mdl-15386164