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1.
An Med Interna ; 23(3): 124-6, 2006 Mar.
Article in Spanish | MEDLINE | ID: mdl-16737433

ABSTRACT

Corynebacterium pseudodiphteriticum has been considered a very infrequent respiratory pathogen. We report three cases of pneumonia due to C. pseudodiphteriticum, describing their clinical and microbiological features. There were two patients with pre-existing chronic respiratory disease, one of their with steroidal therapy, and other associated with endotracheal intubation. The diagnostic was made by Gram stain and quantitative cultures from respiratory tract specimens. All patients were cured after treatment with amoxicillin-clavulanate, ceftriaxone and vancomycin respectively. C. pseudodiphteriticum must be consider as a possible causal agent of pneumonia in patients with underlying respiratory disease or endotracheal intubation. Antimicrobial susceptibility testing of C. pseudodiphteriticum may be useful for correct treatment of infected patients, but beta-lactam antibiotics are an appropriate therapeutic option against this bacteria.


Subject(s)
Corynebacterium Infections/microbiology , Corynebacterium/isolation & purification , Pneumonia, Bacterial/microbiology , Aged , Amoxicillin-Potassium Clavulanate Combination/therapeutic use , Anti-Bacterial Agents/therapeutic use , Ceftriaxone/therapeutic use , Corynebacterium/classification , Corynebacterium/drug effects , Corynebacterium/pathogenicity , Diabetes Mellitus, Type 1/complications , Drug Resistance, Multiple, Bacterial , Drug Therapy, Combination , Female , Humans , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/therapeutic use , Intubation, Intratracheal/adverse effects , Male , Multiple Trauma/complications , Ofloxacin/therapeutic use , Prednisone/adverse effects , Prednisone/therapeutic use , Pulmonary Disease, Chronic Obstructive/complications , Sjogren's Syndrome/complications , Sjogren's Syndrome/drug therapy , Smoking/adverse effects , Vancomycin/therapeutic use
2.
Acta pediatr. esp ; 64(5): 240-243, mayo 2006. tab
Article in Es | IBECS | ID: ibc-049964

ABSTRACT

Streptococcus bovis es una causa reconocida de bacteriemia y endocarditis en adultos, habitualmente en asociación con enfermedades gastrointestinales. Por el contrario, este microrganismo es una causa muy infrecuente de enfermedad infecciosa neonatal y pediátrica. Se presentan dos casos de infección neonatal con aislamiento de S. bovis (biotipo 11/2) en sangre.El primer paciente debutó con fiebre y sintomatología gastrointestinal y se recuperó de forma favorable tras el tratamiento antibiótico. El segundo paciente padeció distrés respiratorio, su evolución fue fulminante y murió a las 22 horas de vida apesar del tratamiento. En la revisión efectuada de la bibliografía comprobamos que se han comunicado con anterioridad 27 casos de infección neonatal con aislamiento de S. bovis en sangre. En esta revisión, la infección se asocia con un relativo buen pronóstico pero, de forma excepcional, como ocurrió en el segundo paciente, la evolución puede ser fulminante y rápidamente mortal


Streptococcus bovis is a recognized cause of bacteremia and endocarditis in adults, usually in association with gastrointestinal diseases. In contrast, this microorganism is a very infrequent cause of neonatal and pediatric infectious diseases. Were port two cases of neonatal infection in which S. bovis (biotype 11/2) was isolated from blood. The first patient presented with fever and gastrointestinal symptoms and recovered after antibiotic treatment. The second patient presented with respiratory distress. His course was fulminant and, in spite of therapy, he died 22 hours after birth. A review of the literature revealed only 27 previously reported cases of neonatal infectiondue to S. bovis in which this microorganism was isolated from blood. In this review, the infection appeared to be associated with a relatively good prognosis, but occasionally, as in the case of our second patient, the course can be rapid and fulminant and the outcome fatal


Subject(s)
Male , Infant, Newborn , Humans , Bacteremia/microbiology , Streptococcus bovis/pathogenicity , Streptococcal Infections/complications , Anti-Bacterial Agents/therapeutic use
3.
An. med. interna (Madr., 1983) ; 23(3): 124-126, mar. 2006. tab
Article in Es | IBECS | ID: ibc-046840

ABSTRACT

Corynebacterium pseudodiphteriticum es considerado un patógeno respiratorio muy infrecuente. Presentamos 3 casos de neumonía atribuibles a C. pseudodiphteriticum, describiendo sus características clínicas y microbiológicas. En los dos primeros casos existía enfermedad respiratoria crónica previa, además de corticoterapia asociada en uno de ellos, y en el caso restante tan solo maniobras repetidas de intubación endotraqueal. El diagnóstico se orientó por la tinción de Gram, confirmándose con cultivos cuantitativos de muestras respiratorias. La evolución fue favorable en los 3 casos, tras tratamiento con amoxicilina-clavulánico, ceftriaxona y vancomicina respectivamente. C. pseudodiphteriticum debe ser tenido en cuenta como posible agente causal de neumonías, sobre todo en pacientes con patología respiratoria subyacente o sometidos a intubación endotraqueal. El tratamiento debe ajustarse al patrón de susceptibilidad a antimicrobianos, aunque los betalactámicos parecen ser la opción más adecuada


Corynebacterium pseudodiphteriticum has been considered a very infrequent respiratory pathogen. We report three cases of pneumonia due to C. pseudodiphteriticum, describing their clinical and microbiological features. There were two patients with pre-existing chronic respiratory disease, one of their with steroidal therapy, and other associated with endotracheal intubation. The diagnostic was made by Gram stain and quantitative cultures from respiratory tract specimens. All patients were cured after treatment with amoxicillin-clavulanate, ceftriaxone and vancomycin respectively. C. pseudodiphteriticum must be consider as a possible causal agent of pneumonia in patients with underlying respiratory disease or endotracheal intubation. Antimicrobial susceptibility testing of C. pseudodiphteriticum may be useful for correct treatment of infected patients, but beta-lactam antibiotics are an appropriate therapeutic option against this bacteria


Subject(s)
Aged , Humans , Corynebacterium/isolation & purification , Corynebacterium Infections/microbiology , Pneumonia, Bacterial/microbiology , Amoxicillin-Potassium Clavulanate Combination/therapeutic use , Anti-Bacterial Agents/therapeutic use , Ceftriaxone/therapeutic use , Corynebacterium/classification , Corynebacterium , Corynebacterium/pathogenicity , Drug Resistance, Multiple, Bacterial , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/therapeutic use , Intubation, Intratracheal/adverse effects , Ofloxacin/therapeutic use , Prednisone/adverse effects , Prednisone/therapeutic use , Pulmonary Disease, Chronic Obstructive/complications , Sjogren's Syndrome/complications , Sjogren's Syndrome/drug therapy , Vancomycin/therapeutic use
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