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1.
BMJ Case Rep ; 16(5)2023 May 16.
Article in English | MEDLINE | ID: mdl-37192779

ABSTRACT

Organising pneumonia after a mild COVID-19 infection has been increasingly reported and poses a diagnostic challenge to physicians especially in immunocompromised patients. We report a patient with a background of lymphoma in remission on rituximab who presented with prolonged and persistent fever after recovering from a mild COVID-19 infection. The initial workup showed bilateral lower zone lung consolidation; however, the infective and autoimmune workup were unremarkable. Subsequently, a bronchoscopy with transbronchial lung biopsy confirmed the diagnosis of organising pneumonia. A tapering glucocorticoid regimen was commenced with prompt resolution of the patient's clinical symptoms, and subsequent resolution of biochemical markers and radiological lung changes 3 months later. This case highlights the importance of early recognition of the diagnosis of organising pneumonia in immunocompromised populations after a mild COVID-19 infection as it shows promising response to glucocorticoid therapy.


Subject(s)
COVID-19 , Organizing Pneumonia , Pneumonia , Humans , COVID-19/pathology , Glucocorticoids/therapeutic use , Pneumonia/drug therapy , Lung/pathology , Immunocompromised Host
2.
BMJ Case Rep ; 15(4)2022 Apr 15.
Article in English | MEDLINE | ID: mdl-35428667

ABSTRACT

There is a paradigm shift in the detection of phaeochromocytomas with more being identified as adrenal 'incidentalomas'. While majority of these individuals are asymptomatic, they are nevertheless at risk of subtle cardiovascular dysfunction and phaeochromocytoma crises. Therefore, early resection of phaeochromocytomas, even if subclinical, is recommended. However, the perioperative management can be challenging as the normotension can limit the initiation and titration of alpha-blockade. We present a man in his 60s with a subclinical phaeochromocytoma, discuss the evaluation of an incidentally discovered adrenal nodule, as well as the practical considerations in the perioperative management.


Subject(s)
Adrenal Gland Neoplasms , Pheochromocytoma , Adrenal Gland Neoplasms/diagnosis , Adrenal Gland Neoplasms/surgery , Humans , Incidental Findings , Male , Pheochromocytoma/diagnosis , Pheochromocytoma/surgery
3.
Hamostaseologie ; 40(5): 592-593, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32894875

ABSTRACT

COVID-19 coagulopathy is a hypercoagulable state which predisposes to venous, arterial and small vessel thrombosis. We describe a patient with COVID-19 who developed an acute superior mesenteric vein thrombosis with acute intestinal obstruction despite adequate anticoagulation.


Subject(s)
Blood Coagulation Disorders/complications , COVID-19/complications , Intestinal Obstruction/complications , Ischemia/complications , Mesenteric Ischemia/complications , Acute Disease , Adult , COVID-19/virology , Humans , Male , SARS-CoV-2/isolation & purification
4.
Int J Surg Pathol ; 28(5): 549-552, 2020 Aug.
Article in English | MEDLINE | ID: mdl-31865805

ABSTRACT

Perivascular epithelioid cell (PEC) tumors are rare tumors of mesenchymal origin and can affect many anatomic regions. Although these tumors are usually benign, malignant variants exist. We document for the first time a malignant PEComa arising from the pleura of a 43-year-old Malay woman. The pathology of the tumor as well as differential diagnoses is discussed.


Subject(s)
Perivascular Epithelioid Cell Neoplasms/pathology , Pleural Neoplasms/pathology , Adult , Fatal Outcome , Female , Humans , Perivascular Epithelioid Cell Neoplasms/diagnosis , Pleural Neoplasms/diagnosis
5.
J Clin Neurosci ; 21(6): 1073-4, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24380757

ABSTRACT

Soft tissue chondromas are rare, benign extra-skeletal tumours of cartilaginous origin, which may rarely occur within the spinal canal. We report a patient who presented with left lumbar radiculopathy, and a peripherally-enhancing dumbbell shaped soft tissue mass involving both the intraspinal and extraspinal compartments on MRI. This was misdiagnosed as a neurogenic tumour and the patient underwent surgical removal. Histological examination revealed cartilaginous tissue. Although rare, soft tissue chondromas should be considered in the differential diagnosis of spinal dumbbell shaped tumours, especially if MRI shows peripheral contrast enhancement.


Subject(s)
Chondroma/diagnosis , Lumbar Vertebrae/pathology , Radiculopathy/diagnosis , Soft Tissue Neoplasms/diagnosis , Chondroma/surgery , Diagnosis, Differential , Female , Humans , Lumbar Vertebrae/surgery , Middle Aged , Radiculopathy/surgery , Soft Tissue Neoplasms/surgery
8.
Arch Pathol Lab Med ; 129(6): e138-40, 2005 Jun.
Article in English | MEDLINE | ID: mdl-15913441

ABSTRACT

Squamous lesions of the gallbladder are uncommon. We report a case of a pseudoepidermoid cyst in a middle-aged woman arising on a background of chronic cholecystitis and cholelithiasis, which induced exuberant squamous metaplasia of the entire gallbladder mucosa, clinically mimicking a gallbladder tumor. To our knowledge, this is the first such reported case in the English literature.


Subject(s)
Epidermal Cyst/pathology , Gallbladder Diseases/pathology , Mucous Membrane/pathology , Adenocarcinoma/diagnosis , Biomarkers/metabolism , Cholecystitis/complications , Cholecystitis/pathology , Cholecystitis/surgery , Choledocholithiasis/complications , Choledocholithiasis/pathology , Choledocholithiasis/surgery , Chronic Disease , Common Bile Duct/pathology , Common Bile Duct/surgery , Diagnosis, Differential , Epidermal Cyst/metabolism , Epidermal Cyst/surgery , Female , Gallbladder Diseases/metabolism , Gallbladder Diseases/surgery , Gallbladder Neoplasms/diagnosis , Hepatic Duct, Common/pathology , Hepatic Duct, Common/surgery , Humans , Immunohistochemistry , Jejunostomy , Metaplasia/pathology , Middle Aged , Treatment Outcome
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