ABSTRACT
The experiments on mongrel white rats studied toxicity of the products appearing during thermal destruction of conveyer tape TK-200 based on polyvinyl chloride and used in coal mines. The studies helped to define parameters of acute toxicity and the MACs for products of the conveyer tape burning, considering the main contents and the exposure intensity for 30-120 minutes; to determine jeopardy class; to calculate specific volatilization; to design recommendations for prevention of poisoning during fire in the mines.
Subject(s)
Coal Mining , Fires , Polyvinyl Chloride/toxicity , Air Pollutants, Occupational/toxicity , Animals , Hot Temperature , Male , Maximum Allowable Concentration , RatsSubject(s)
Coal Mining , Haptoglobins/analysis , Adult , Disease Susceptibility/blood , Genetic Predisposition to Disease , Heat Exhaustion/blood , Heat Exhaustion/genetics , Humans , Middle Aged , Occupational Diseases/blood , Occupational Diseases/genetics , Phenotype , Pneumoconiosis/blood , Pneumoconiosis/genetics , UkraineABSTRACT
A study was performed on white rats of the physiological, biochemical, haematological and pathomorphological indices in separate and combined actions of formaldehyde (FA) (60.0 +/- 12.7 mg/m3 in one-time exposition and 7.2 +/- 1.2 mg/m3 in a 30-day long experiment) with a concomitant increased barometric pressure (IBP) characteristic of deep coal mines (111 and 123 kPa corresponding to 1000 and 2000 m deep mines respectively). It was established that, at 123 kPa, lipoid peroxide oxidation process was stimulated in combination with microcirculatory disorders, growing FA concentration in the serum and pulmanary tissues. The shifts were still more vivid at growing IBP.
Subject(s)
Atmospheric Pressure , Formaldehyde/toxicity , Animals , Coal Mining , Formaldehyde/analysis , Formaldehyde/blood , Lipid Peroxidation , Lung/chemistry , Male , Rats , Time FactorsABSTRACT
A detailed clinico-functional examination allowed to reveal changes in some systems of the body of mine rescuers, namely disorders of external respiratory function of obstructive, restrictive and mixed types, increased tone of the cerebral and peripheral vessels, reduction of their blood filling evidencing unfavourable effects on the rescuer's mechanism connected with psychoemotional overstrain and specific professional factors.
