ABSTRACT
The purpose of the work is to assess changes in the functional state of the microvasculature, study of the features of the morphological parameters of the skin by non-invasive research methods for various morphotypes of aging. The study involved 55 patients with involutional changes in the lower third of the face aged 35 to 65 years, included according with the inclusion and exclusion criteria. 4 morphotypes of aging were identified, depending on which patients were divided into corresponding groups: 1st - 19 patients with deformational type, 2nd - 17 with tired type, 3rd - 8 with fine wrinkled type, 4th - 11 with mixed morphotype of aging. To study the condition of the patients' skin, laser Doppler flowmetry and ultrasound examination of the skin (22 Mhz) were used. The method of laser Doppler flowmetry revealed significant changes when comparing microcirculation indices and the ultrasound method for examining deformational and fine wrinkled type (p<0,05). In the deformational type and mixed type, a predominantly atonic type of microcirculation was observed (9,42±3,71 and 9,56±2,31 perf. u., respectively), and in fine wrinkled spastic type of microcirculation (7,86±1,6 perf. u.), in the oral morphotype the microcirculation index was within the normal range of 7,86±1,6 perf. u. The data of ultrasound examination of the skin made it possible to reveal in the deformational morphotype of aging high values of the thickness of the epidermis (125,94±27,84 µm), the dermis (1 439±118,11 µm) and the density of the dermis (12±2,59 a. u.) compared with the thickness of the epidermis 85±22,01 µm, the thickness of the dermis (1 130±68,55 µm) and the density of the dermis (7,87±2,1 c. u.) in the fine wrinkled morphotype of aging.
Subject(s)
Skin Aging , Aging , Humans , Laser-Doppler Flowmetry , Microcirculation , SkinSubject(s)
Breast Implants/adverse effects , Pseudolymphoma/diagnosis , Silicone Gels/adverse effects , Skin Diseases/diagnosis , Adult , Female , Humans , Methoxsalen/therapeutic use , Photochemotherapy , Pseudolymphoma/drug therapy , Pseudolymphoma/etiology , Skin Diseases/drug therapy , Skin Diseases/etiologyABSTRACT
Prednisolone in therapeutic concentrations blocks Ca(2+) channels of lymphocyte plasma membranes and prevents arachidonic acid-induced Ca(2+) entry into the cells. Glucocorticoid virtually did not modulate arachidonic acid-stimulated release of Ca(2+) from intracellular stores. No appreciable effect of the hormone on mitogen-induced changes in the intracellular content of cAMP was detected.
