CBCovid19EC: A dataset complete blood count and PCR test for COVID-19 detection in Ecuadorian population.

In this work, we present the complete blood count data and PCR test results of a population of Ecuadorians from different provinces, primarily residing in the Andean region, especially in Quito. PCR was the standard test to detect Covid-19 during the pandemic since 2020. The data were obtained between March 1st and August 12th, 2021. Segurilab and Previne Salud laboratories performed the tests. The dataset contains about 400 clinical cases. Each patient agreed to participate in the study by sharing the results of their PCR (reverse transcription polymerase chain reaction) tests and CBC (complete blood count). CBC test measured several components and features of the blood, including red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The shared data are intended to provide researchers with input to analyze various events associated with the diagnosis of Covid-19 linked to potential diseases identified in the components measured in the CBC test. These data are helpful for pattern analysis of blood components in modeling prediction and clustering problems. The components measured in the complete blood count and CRP together can be helpful for the analysis of different medical conditions using machine learning algorithms.

Una mirada transcompleja de la Violencia Juvenil Delincuencial en Venezuela / A transcomplex look at the delinquent youth violence in Venezuela

Se realizó una investigación bajo el enfoque integrador transcomplejo en la búsqueda de una interpretación transdisciplinaria, multidimensionada y dinámica de la violencia juvenil delincuencial, cuyo propósito fue develar las posturas epistemológicas que subyacen en la lógica de intervención de los diversos sectores de las políticas públicas en relación a la violencia delincuencial, así como la resignificación, mediante un diálogo de saberes, con sujetos significantes y con los significados socioculturalmente construidos del contexto teórico disciplinario de la violencia juvenil delincuencial en el Estado Aragua , con el fin de aportar constructos teóricos que propicien un repensar de las políticas públicas desde una perspectiva transcompleja y transdisciplinaria. La Transmetódica se fundamentó en la transdisciplinariedad, la hermenéutica y la etnografía. Se llevó a cabo en cuatro etapas que confluyeron para desmontar el discurso de los informantes en relación a la realidad y contrastarlos con las corrientes del pensamiento que han sustentado la matriz epistemológica vigente, para luego develar desde una perspectiva transcompleja y multidimensionada los aspectos ocultos en el discurso; brindando la posibilidad de resignificar estos hallazgos hacia una alternativa epistemológica integradora. Se evidencia la necesidad de trascender las lógicas homogeneizadoras de las políticas de control social tradicionales fundamentadas en el etiquetamiento y exclusión social, mediante un proceso masivo de fortalecimiento axiológico y praxiológico de la institucionalidad social, para lograr un cambio paradigmático hacia una nueva visión multidimensionada y transcompleja de la lógica de las estrategias de prevención y control social de la violencia juvenil delincuencial, y su resignificación en un horizonte sociocultural de convivencia pacífica.

An investigation was carried out under the integrative transcomplex approach in the search for a transdisciplinary, multidimensional and dynamic interpretation of juvenile delinquent violence, whose purpose was to reveal the epistemological positions that underlie the intervention logic of the various sectors of public policies in relation to to criminal violence, as well as resignification, through a dialogue of knowledge, with significant subjects and with the socioculturally constructed meanings of the disciplinary theoretical context of juvenile delinquent violence in the State of Aragua, in order to provide theoretical constructs that promote a rethinking of public policies from a transcomplex and transdisciplinary perspective. Transmethodics was based on transdisciplinarity, hermeneutics and ethnography. It was carried out in four stages that converged to disassemble the informants' discourse in relation to reality and contrast them with the currents of thought that have sustained the current epistemological matrix, and then reveal the hidden aspects in the current epistemological matrix from a transcomplex and multidimensional perspective. speech; providing the possibility of resignifying these findings towards an integrative epistemological alternative. There is evidence of the need to transcend the homogenizing logics of traditional social control policies based on labeling and social exclusion, through a massive process of axiological and praxiological strengthening of social institutions, to achieve a paradigmatic shift towards a new multidimensional and trans-complex vision of the logic of the strategies of prevention and social control of delinquent juvenile violence, and its resignification in a sociocultural horizon of peaceful coexistence.

Major allergen from Amaranthus palmeri pollen is a profilin: Isolation, partial characterisation and IgE recognition.

BACKGROUND: Pollens represent a rich source of proteins that are also potential elicitors of IgE-mediated pollen allergy. Sensitisation to panallergens could play an important role in diagnosis and specific immunotherapy, because these molecules are present in different plant pollens and plant foods and have marked structural similarity in different species. Profilins are one of the most common panallergens to be studied because they are responsible for a large number of sensitisations and are clearly related to cross-reactivity and co-sensitisation. This study aimed to isolate and characterise a new allergen of Amaranthus palmeri pollen and to determine its allergenicity. METHODS: A. palmeri pollen profilin was purified using poly-l-proline-Sepharose affinity chromatography followed by anion exchanger chromatography. Identification of purified protein was carried out by mass spectrometry. Specific IgE was estimated in sera of patients with positive skin prick test to A. palmeri pollen extract, by enzyme-linked immunosorbent assay (ELISA). PRINCIPAL FINDINGS: Purified protein appeared as a single band at 14 kDa in SDS-PAGE gel. Mass spectrometric analysis of the gel band identified two highly conserved peptides corresponding to allergenic profilins from pollen of other plants. Sera from about 60% of allergic patients have IgE that recognises the purified A. palmeri protein. CONCLUSION: A 14 kDa protein of A. palmeri pollen was purified and identified as allergenic profilin, which was recognised by sera from pollen allergic patients.

Developments in the field of allergy in 2011 through the eyes of Clinical and Experimental Allergy.

As in previous years, we felt it would be of value to our readership to summarize the new information provided by the authors who have published in Clinical and Experimental Allergy in 2011 and set this in the context of recent advances in our understanding of the pathogenesis and management of allergic disease in all its many manifestations. In 2011, about 210 articles were published in Clinical and Experimental Allergy including editorials, reviews, opinion articles, guidelines, letters, book reviews and of course at the heart of the journal, papers containing original data. As before, this review is divided into sections based on the way the journal is structured, although this year we have grouped together all the papers dealing with mechanisms of allergic disease, whether they involve patients (clinical mechanisms), pure in vitro studies (basic mechanisms) or animal models (experimental models), as we felt this was a more coherent way to deal with the subject. In the field of asthma and rhinitis, the relationship between airway inflammation and airway dysfunction was of perennial interest to investigators, as were phenotypes and biomarkers. Aspirin hypersensitivity appeared in studies in several papers and there was new interest in asthma in the elderly. The mechanisms involved in allergic disease describe advances in our understanding of T cell responses, the relationship between inflammation and disease, mast cell and basophil activation, steroid resistance and novel therapies. In the section dealing with epidemiology, studies seeking to identify risk factors for allergic disease including vitamin D are prominent, as once again are studies investigating gene-environment interactions. The clinical allergy section focuses on drug allergy, food allergy and immunotherapy. The area of oral immunotherapy for food allergy is well covered and we were grateful to Stephen Durham for guest editing an outstanding special issue on immunotherapy in the centenary year of Leonard Noon's pioneering work. Lastly, in the field of allergens, the interest in component-resolved diagnosis continues to grow and there are also articles describing important novel cultivars and the effect of food processing on the allergenic properties of foods. Another terrific year, full of important and high-quality work,which the journal has been proud to bring to the allergy community.

Chemokine CC-ligand 5 production and eosinophil activation into the upper airways of aspirin-sensitive patients.

BACKGROUND: Airway eosinophilia is a hallmark of aspirin-sensitive asthma/rhinitis. OBJECTIVE: We have investigated chemokine CC-ligand 5 (CCL5) production and its association with eosinophil activation in the upper airways of aspirin-sensitive patients both in vivo and in vitro. METHODS: Twenty aspirin-sensitive asthma/rhinosinusitis patients, 18 atopic-tolerant asthma/rhinosinusitis patients and 15 healthy control subjects took part in the study. All subjects were challenged with saline and lysine-acetylsalicylic acid (L-asa) on separate occasions. Nasal lavages were obtained at baseline and 120 min after challenge and analysed for mediators' release. RESULTS: When compared with control subjects, the baseline levels of CCL5 were significantly increased in both sensitive and tolerant patients (there was no significant difference in CCL5 concentrations between these two groups, P>0.05). However, L-asa nasal challenge induced significantly increased levels of CCL5 in the sensitive patients but not in the tolerant subjects (median: 380 vs. 140 pg/mL, P<0.0001). Similarly, the concentrations of both eosinophil cationic protein (ECP) and cysteinil leukotriene (cys-LTs) were increased significantly in the aspirin-sensitive but not in the tolerant patients. There was a trend towards a significant correlation between CCL5 and ECP concentrations in the sensitive patients following L-ASA challenge. On incubation with aspirin, nasal tissue derived from aspirin-sensitive but not that derived from tolerant subjects released increased CCL5 levels in culture. As determined by immunohistochemistry, CCL5 was predominantly localized to the nasal airway epithelium. CONCLUSION: Altogether, these findings suggest that CCL5 is released in aspirin-sensitive asthma/rhinosinusitis.

Role of monocyte chemotactic protein-3 and -4 in children with virus exacerbation of asthma.

Macrophages play a crucial role in respiratory viral infections. However, the mechanisms by which these cells are recruited locally are not fully understood. The current authors studied the role of the chemokines monocyte chemotactic protein (MCP)-1, -2, -3 and -4 on monocyte/macrophage recruitment during respiratory viral infections. Levels of these chemokines were investigated in nasal aspirates from 6-12-yr-old children suffering from respiratory viral infections, caused by rhinoviruses, influenza viruses, parainfluenza viruses, adenoviruses and respiratory syncytial virus. MCP-3 and -4 were significantly higher in samples derived from virus-infected children compared with samples from the same children when they had been asymptomatic. Concentrations of both chemokines were found to significantly correlate with the number of recruited nasal macrophages. Chemotaxis assays showed that purified MCP-3 and -4 from nasal aspirates showed biological activity in vitro. There were no significant differences in MCP-1 and -2 levels between both groups. The present data indicates that monocyte chemotactic protein-3 and -4 may have an important role in macrophage recruitment in children with proven upper respiratory viral infections. These chemokines could be potential targets for therapeutic intervention in respiratory viral infections.

Muerte fetal intrauterina por nudo real: a propósito de un caso clínico / Intrauterine fetal death by royal knot: a purpose of a case clinical

El cordón umbilical tiene una longitud de 50-60 centímetros en una gestación de término y constituye la comunicación entre placenta y feto. Entre las patologías de cordón están los nudos falsos (debidos a asas vasculares recubiertas por la acumulación de la gelatina de Wharton que se forma porque la longitud de los vasos supera a la del cordón) y reales. Este último es el que con más frecuencia lleva a muerte fetal intrauterina por causa funicular. Inexplicable cuando el producto se encuentra dentro del útero y evidenciable al producirse su posterior salida, como ocurrió en el caso presentado a continuación.

Protocolo de estudio en el niño con infección urinaria: Hospital Padre Justo Rubio: Estado Táchira año 1998-2002 / Protocolo of study in children with urinary infections: Hospital Padre Justo Rubio, state Tachira: years 1998-2002

La infección urinaria es una de las afecciones más importantes dentro de la urología pediátrica debido a su elevada frecuencia, dificultad diagnóstica, gran tendencia a recurrencias y posibilidad de generar insuficiencia renal. La relación varón/mujer aumenta con la edad y es mayor después de los 4 años 10:1. El 5-15 por ciento de los niños en edad escolar con una infección urinaria presentan anomalías renales que requieren intervención quirúrgica. Se revisaron 50 historias clínicas de niños hospitalizados con el diagnósticos de infección urinaria en el Hospital Tipo II, Padre Justo de Rubio, Estado Táchira, para el periodo 1998-2002. Se realizó un estudio retrospectivo incluyendo niños que presentaron clínica presuntiva de infección urinaria, con uroanálisis patológico y urocultivo positivo; para determinar a que porcentaje de niños se les cumplió el protocolo de estudio de infección urinaria encontrando: solo el 26 por ciento de los pacientes fueron estudiados, donde el sexo más afectado correspondio al femenino (53.84 por ciento), representado por el grupo etáreo de los preescolares., se les realizó Ultrasonografía renal y uretrocistografía miccional revelando anormalidades en el 15.4 por ciento y en el 54 por ciento respectivamente. El 15 por ciento ameritó urografía de eliminación y un 8 por ciento gammagrafía renal. Y solo el 46 por ciento ameritó tratamiento quirúrgico.

Three-yr follow-up of a type 1 diabetes mellitus patient with an islet xenotransplant.

In order to alleviate the shortage of human donors, the use of porcine islets of Langerhans for xenotransplantation in diabetic patients has been proposed as a solution. To overcome rejection, we have developed a procedure for protecting the islets by combining them with Sertoli cells and placing them in a novel subcutaneous device, that generates an autologous collagen covering. A type 1 diabetic woman was closely monitored for 10 months, and then transplanted in two devices with two months of difference and a third time after 22 months. Here we present a three-yr follow-up. The close monitoring induced a rapid decrease in exogenous insulin requirements, which stabilized between 19 and 28 IU/d for nine months. After transplantation, the requirements reduced further to below 6 IU/d and for some weeks she was insulin free. Glycosylated hemoglobin levels decreased concomitantly. Porcine insulin could be detected in the serum after a glucose challenge and insulin positive cells inside a removed device after two yr. No complications have arisen and no porcine endogenous retrovirus infection has been detected through PCR and RT-PCR. This case demonstrates the feasibility of using the xenotransplantation of porcine cells to alleviate metabolic complications and insulin requirements in type 1 diabetic patients.

Valor Predictivo para Riesgo Cardiovascular de los Componentes del Sindrome Metabólico, según criterios de la FID y ATP III, en Trabajadores de un Hospital del Estado Aragua, 2006. / Predictive value of metabolic syndrome components on cardiovascular risk according to FID and ATP III, criteria in Hospital personnel Aragua State, 2006.

Con el propósito de determinar el valor predictivo para riesgo cardiovascular de los componentes del sindrome metabólico, según los criterios de la FID (2005) y ATP III (2001), se realizó un estudio descriptivo correlacional en 118 trabajadores de un Hospital tipo III del estado Aragua, a quienes se les determinó la prevalencia de los componentes del síndrome metabólico, el perfil lipídico, los antecedentes patológicos y el riesgo cardiovascular según el Score de Framingham. comparando la prevalencia de los componentes del sindrome metabólico con el riesgo cardiovascular encontrado, según los grupos de criterios diagnósticos de ambas clasificaciones, para estimar finalmente la correlación estadística de los mismos. En los resultados que este estudio encontró una alta prevalencia en los trabajadores, de Síndrome Metabólico según las definiciones de la FID y la ATP III. Al comparar estadís-ticamente la prevalencia por grupos de edad se encuentra una diferencia significativa para la clasificación de la ATPIII. Finalmente, se pudo observar, de acuerdo a los resultados de esta investigación, al Síndrome Metabólico como un factor independiente que se correlacionó significativamente con el riesgo cardiovascular, según la definición de la FID. Por lo que se concluye que ambas clasificaciones proveen beneficios en la detección y diagnóstico de Síndrome Metabólico.

As to determine the predictive value on cardiovascular risk of metabolic syndrome components, according to FID (2005) and ATP III (2001) criteria, a correlational descriptive study was performed on 118 workers of a type III Hospital in Aragua State. The determination of prevalence of the components of metabolic syndrome, lipidic profile, pathologic record and cardiovascular risk according to Framingham Score was determined a comparison between the prevalence of the components of metabolic syndrome with the cardiovascular risk assessed according to diagnostic criteria groups of both classifications allowed the estimation of its statistic correlation. As a result of the present research, a high prevalence of metabolic syndrome according to the FID and ATP III definitions was assessed. A statistical comparison of the prevalence among age groups indicated a significant difference as to the ATP III classification concerns. Finally, according to the results, Metabolic Syndrome appears as an independent factor significantly correlated with cardiovascular risk according to FID classification. Our conclusion is that both classifications are useful for the detection and diagnosis of Metabolic Syndrome.

CC chemokine ligand 1 is released into the airways of atopic asthmatics.

CC chemokine ligand (CCL)1/I-309 is a potent attractant for T-helper cell type 2 lymphocytes. The present study investigates whether this cytokine is released in the bronchoalveolar fluid (BALF) of asthmatic patients. Measurements of CCL1 using ELISA showed that levels of this cytokine were significantly elevated in BALF from asthmatics compared with normals (median (range) 193 (120-449) pg.mL(-1) versus 30 (21-55) pg.mL(-1)). Differential cell counts in BALF showed that either lymphocyte or eosinophil numbers were elevated in asthmatic compared with normal subjects (10.8 x 10(3).mL(-1) versus 1.0 x 10(3).mL(-1) and 1.7 x 10(3).mL(-1) versus 0.2 x 10(3).mL(-1), respectively). There was a trend towards a significant correlation between CCL1 levels and lymphocyte numbers in BALF. Separation of BALF using sequential CCL1 affinity column and reverse-phase high-performance liquid chromatography allowed detection of biologically active CCL1. Using immunohistochemistry, CCL1 immunoreactivity was localised predominantly to the airway epithelium. Interestingly, there was a significant correlation between CC chemokine ligand 1 levels and epithelial cell numbers in bronchoalveolar lavage fluid and between these cells and lymphocyte numbers. Moreover, interleukin-4, interleukin-13 and interferon-gamma stimulated primary bronchial airway epithelial cells to release CC chemokine ligand 1. These findings suggest that CC chemokine ligand 1 may play a role in lymphocyte recruitment in bronchial asthma.

High household infestation rates by synanthropic vectors of Chagas disease in southern Ecuador.

Entomological surveys were conducted in five rural communities (138 domiciliary units [DUs]) in the southern Andes of Ecuador. Adobe walls and ceramic tile roofs were predominant construction materials. A 35% house infestation rate with Panstrongylus chinai (Del Ponte, 1929) (0.7%), Panstrongylus rufotuberculatus (Champion, 1899) (0.7%), Rhodnius ecuadoriensis (Lent & León, 1958) (27%), and/or Triatoma carrioni (Larrousse, 1926) (7%) was found. Adults and nymphs of R. ecuadoriensis and T. carrioni were found in intradomiciliary and peridomiciliary areas. Breeding triatomine colonies were present in 85% of infested DUs, and the average insect crowding was 52+/-113 triatomine bugs per infested house. T. cruzi-like organisms were found by microscopic examination in the feces or hindgut but not the salivary glands of 4% of examined R. ecuadoriensis and 12% T. carrioni. Serological tests detected a general anti-T. cruzi antibody seroprevalence of 3.9% (n = 1136). Only 2% of individuals had heard of Chagas disease, and although triatomines were reported as a major nuisance by the population they were not considered vectors of disease. Additional baseline field research is needed for the design and implementation of a Chagas disease control program in the region.

The monocyte-derived chemokine is released in the bronchoalveolar lavage fluid of steady-state asthmatics.

Infiltration of the airways by T helper type 2 (Th2) lymphocytes is a well-recognized feature of bronchial asthma. Monocyte-derived chemokine (MDC) is a potent attractant which activates Th2 lymphocytes via the chemokine receptor CCR4. We have investigated both leukocyte recruitment and MDC release into the airways of asthmatic patients. Differential cell counts in bronchoalveolar lavage (BAL) fluid showed that numbers of lymphocytes and eosinophils were elevated in asthmatics compared with normal subjects (median, 6.1 vs. 1.0 x 10(3)/ml, P < 0.005 and 1.4 vs. 0.24 x 10(3)/ml, P = 0.001, respectively). By enzyme-linked immunosorbent assay it was demonstrated that MDC concentrations were significantly elevated in BAL fluid from asthmatics compared with normals (medians 282 pg/ml, range 190-780 pg/ml vs. median 29 pg/ml range 17-82 pg/ml, P < 0.001). Interestingly, there was a significant correlation between MDC levels and the bronchoconstrictive response to methacholine [PC20 forced expiratory volume (FEV)1, r = -0.78, P = 0.001], suggesting that MDC may be involved in the severity of the disease. By immunohistochemistry, MDC was localized predominantly to the bronchial epithelium in bronchial biopsies derived from stable asthmatics. Moreover, primary human airway epithelial cells were found to release MDC upon cytokine stimulation. These findings suggest that MDC may play a major role in the pathogenesis of bronchial asthma.

Interleukin (IL)-4 and to a lesser extent either IL-13 or interferon-gamma regulate the production of eotaxin-2/CCL24 in nasal polyps.

BACKGROUND: Eotaxin-2/CCL24 is a potent eosinophil attractant that has been implicated in the recruitment of eosinophils in allergic disease. We have investigated whether the cytokines interleukin (IL)-4, IL-13, and interferon (IFN)-gamma regulate eotaxin-2/CCL24 in nasal polyps. METHODS: Nasal polyps were cultured in the presence of the cytokines described above and the concentration of eotaxin-2/CCL24 was measured in the culture supernatant. RESULTS: IL-4 was found to be the major stimulus for eotaxin-2/CCL24 production from nasal polyps followed by IL-13 and IFN-gamma. IL-4 induced eotaxin-2/CCL24 in a dose-dependent manner with concentrations as low as 0.1 ng/ml being able to induce eotaxin-2/CCL24. By immunohistochemistry, eotaxin-2/CCL24 immunoreactivity was localized to mononuclear cells in the IL-4 stimulated nasal polyp tissue. Interestingly, nasal turbinates obtained from patients suffering from nonallergic rhinitis (vasomotor rhinitis) were also found to release eotaxin-2/CCL24 both spontaneously and following cytokine stimulation with IL-4 and IFN-gamma being major inducers of this cytokine. CONCLUSIONS: All together these findings suggest that Th1 and Th2 cytokines may regulate eotaxin-2/CCL24 production in nasal polyps and nonallergic rhinits.

Role of the chemokines RANTES, monocyte chemotactic proteins-3 and -4, and eotaxins-1 and -2 in childhood asthma.

Eosinophil recruitment into the airways is a feature of asthma in children. However, the mechanisms by which these cells migrate into the airways are not fully understood. The present study investigated the presence of the eosinophil-activating chemokines regulated on activation, normal T-cell expressed and secreted (RANTES), monocyte chemotactic proteins (MCP)-3 and -4, and eotaxins-1 and -2 in the bronchoalveolar lavage (BAL) fluid obtained from both asthmatic (n=10, age 6-10 yrs) and normal children (n=10, age 5-10 yrs). Measurements of chemokines in BAL fluid showed that levels of RANTES, MCPs-3 and -4, and eotaxins-1 and -2 were significantly increased in fluid obtained from asthmatic children when compared with normal children. Among the different chemokines, RANTES was the cytokine released in greatest quantities in BAL fluid from asthmatic children. There was a significant correlation between the concentrations of MCP-4 and eosinophil numbers in BAL fluid and a trend between both chemokines MCP-3 and eotaxin-2 and eosinophils. Interestingly, the levels of most chemokines correlated with one another. These findings suggest that RANTES monocyte chemotactic proteins-3 and -4, and eotaxins-1 and -2 may regulate eosinophil trafficking into the airways of asthmatic children in a coordinated manner.

Concurrent prediction of drug use among high-risk youth.

Correlates of drug use were examined in a continuation high school sample (n = 1.315), using canonical correlation analysis. Fourteen demographic, attitudes/belief, and psychosocial pressure/ anxiety-type variables were included as concurrent predictors. Eight drug-use-related measures were also placed into the analysis as outcome variables. Two factors were revealed. White ethnicity, not being Latino, all attitude/belief measures, and family conflict and depression showed relatively high loadings on the first predictor factor, and were associated with all drug-use measures. Latino ethnicity and being relatively unacculturated (i.e., tending to speak Spanish), most of the attitude/belief measures (but not sensation seeking or spirituality), and perceived peer approval to use drugs, trait anxiety, and depression showed relatively high loadings on the second predictor factor, and were associated with the hard-drug-use measures. These results suggest that there is a subgroup of unacculturated Latino youth who are anxious, who perceive they will achieve peer approval by using drugs, and who tend to use hard drugs. Indicated drug abuse prevention strategies may need to be tailored to this subgroup when developing and implementing programming.

Valor diagnóstico y pronóstico de la inmunoglobulina E en la cardiopatía isquémica aguda / Diagnosis and prognotic value of the inmunoglobin E at the acute ischemic cardiopathy

Se realizó un estudio de tipo descriptivo y transversal donde se evaluaron 38 pacientes con diagnóstico de infarto de miocardio (IM) o angina inestable, basado en los criterios clínicos, electrocardiográficos y enzimáticos preestablecidos que ingresaron a la unidad de cuidados coronarios del Hospital Dr. Domingo Luciani desde julio hasta septiembre de 1992, descartándose en todos ellos a través del interrogatorio enfermedades alérgicas, asma bronquial, transfunsiones sanguíneas recientes, uso de glucocorticoides, presencia de mieloma IgE o un síndrome de hiper IgE; A través de un frotis de sangre periférica la presencia de eosinofília y mediante examen de heces especial la presencia de parasitosis intestinal. A todos los pacientes se les hizo una determinación de colesterol y triglicéridos a la semana del evento isquémico y de IgE sérica durante los días 1, 3, 8, 15 y 21 desde el ingreso del paciente, tomándose la primera muestra en un tiempo promedio de 11 horas, demostrándose una evidente asociación entre valores elevados IgE séricas y cardiopatía isquémica del tipo IM o angina inestable. Los valores séricos de IgE en nuestros pacientes isquémicos fueron superiores a los descritos en poblaciones normales tanto de estudios internacionales como de nuestro país; además, se demostró una diferencia estadísticamente significativa entre valores IgE sérica del grupo de paciente con IM y el grupo de pacientes con angina inestable estando más elevada en los primeros. En presencia de hábitos tabaquicos y edad superior a los 53 años, la tendencia a presentar niveles elevados de IgE sérica aumenta. De manera que niveles elevados de IgE, al igual que el tabaquismo y la edad pudieran representar un factor de riesgo adicional para cardiopatía isquémica