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Comparative analysis of effects of various types of double-stranded RNA on cultured human laryngeal cancer cells.
Karalova, E M; Kamalyan, L A; Abroyan, L O; Akopyan, L A; Karalyan, Z A; Gasparyan, M G; Dzhagatspanyan, N G; Ter-Pogosyan, Z R; Magakyan, Yu A.
Bull Exp Biol Med ; 137(6): 601-5, 2004 Jun.
Article in English | MEDLINE | ID: mdl-15455096

ABSTRACT

We compared the effects of Na+ and Ca2+ double-stranded RNA on cultured human laryngeal cancer cells by cytomorphometry and cytophotometry. Both agents inhibited proliferation and other cell functions, but to a different extent: Ca2+ double-stranded RNA was more active than Na+ double-stranded RNA.


Subject(s)
Laryngeal Neoplasms/pathology , RNA, Double-Stranded/pharmacology , Tumor Cells, Cultured/drug effects , Animals , Calcium/metabolism , Cell Nucleus/metabolism , Cell Nucleus/ultrastructure , Cell Proliferation , Humans , RNA, Double-Stranded/metabolism , Sodium/metabolism , Tumor Cells, Cultured/cytology
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