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Org Lett ; 17(23): 5910-3, 2015 Dec 04.
Article in English | MEDLINE | ID: mdl-26588585

ABSTRACT

As an extension of previously conducted studies on developing an anti-Alzheimer's disease agent, denosomin (1-deoxy-24-norsominone, an artificial inducer of neurite elongation), derivatives were designed and synthesized based on the hypothesis that our denosomin would exhibit axonal extension activity via a 1,25D(3)-membrane-associated, rapid response steroid-binding protein (1,25D(3)-MARRS) pathway. The biological assay revealed that the hybridization of characteristic δ-lactone in denosomin and the triene moiety in VD(3) was effective to enhance the nerve re-extension activity in amyloid ß (Aß)-damaged neurons.


Subject(s)
Alzheimer Disease/drug therapy , Cholecalciferol/chemical synthesis , Dehydroepiandrosterone/analogs & derivatives , Amyloid beta-Peptides/metabolism , Cell Membrane/metabolism , Cholecalciferol/chemistry , Cholecalciferol/pharmacology , Dehydroepiandrosterone/chemical synthesis , Dehydroepiandrosterone/chemistry , Dehydroepiandrosterone/pharmacology , Molecular Structure , Neurons/pathology
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