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2.
Hepatogastroenterology ; 48(39): 675-7, 2001.
Article in English | MEDLINE | ID: mdl-11462900

ABSTRACT

We report a very rare early-stage case of mantle cell lymphoma, which arose from the rectum. A 60-year-old man presented with a small elastically hard polypoid lesion in the rectum. The lesion was 1.2 x 1.2 cm in size. As a preoperatively barium enema and endoscopy suggested a benign tumor of the rectum, he underwent local excision of a rectal polypoid mass transanally under spinal anesthesia. However, histological examination revealed a malignant lymphoma, because the lesion was histologically characterized by solid growths of small to medium-sized round cells. Furthermore, immunohistochemical tests revealed B-cell marker positivity and CD5 positivity, but cyclin D1 negativity. Since it was reported that lymphomas with a mantle cell lymphoma morphology and CD5 expression, but without cyclin D1 overexpression, exist in about 10% of mantle cell lymphoma cases, we diagnosed his disease as mantle cell lymphoma. To our knowledge, this is the first reported case of an early-stage mantle cell lymphoma, originating from the rectum.


Subject(s)
Lymphoma, Mantle-Cell/surgery , Rectal Neoplasms/surgery , Biomarkers, Tumor/analysis , Colonoscopy , Diagnosis, Differential , Endosonography , Humans , Lymphoma, Mantle-Cell/diagnosis , Lymphoma, Mantle-Cell/pathology , Male , Middle Aged , Rectal Neoplasms/diagnosis , Rectal Neoplasms/pathology , Rectum/pathology , Rectum/surgery
3.
Surg Today ; 29(10): 983-91, 1999.
Article in English | MEDLINE | ID: mdl-10554319

ABSTRACT

Many studies have established the usefulness of serum carcinoembryonic antigen (CEA) oriented serial monitoring for predicting recurrence and prognosis; however, few studies have so far investigated serum CEA-negative recurrence. The aim of this study was to elucidate the nature of CEA-negative recurrence regarding tumor angiogenesis. Fifty-seven patients with T3/T4 rectal cancer were divided into the two groups according to the serum CEA status. Angiogenesis was defined as the intratumoral vessel count by immunohistochemical staining using CD31. The CD31 count was significantly higher in the recurrent patients in both groups and the ratio of nodal involvement was significantly higher in the recurrent patients of the CEA-negative group. Local recurrence mainly developed in the CEA-negative group; however, the CD31 count did not predict the sites of recurrence nor the relapse period in the both groups. A multivariate analysis showed a high CD31 count >26) to be a prognostic factor not only for recurrence but also for survival (P = 0.001, 0.043, respectively). These results suggest that a high degree of tumor angiogenesis in sections of T3/T4 rectal cancer may therefore be an important predictor for CEA-negative recurrence.


Subject(s)
Adenocarcinoma/blood supply , Carcinoembryonic Antigen/blood , Neoplasm Recurrence, Local/pathology , Neovascularization, Pathologic/pathology , Rectal Neoplasms/blood supply , Adenocarcinoma/mortality , Adenocarcinoma/pathology , Aged , Female , Humans , Immunohistochemistry , Male , Middle Aged , Multivariate Analysis , Neoplasm Recurrence, Local/mortality , Platelet Endothelial Cell Adhesion Molecule-1 , Rectal Neoplasms/mortality , Rectal Neoplasms/pathology , Rectum/blood supply , Retrospective Studies
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