ABSTRACT
Laser therapy and laser acupuncture of the biologically active sites were administered to 24 patients with chronic recurrent aphthous stomatitis. The biologically active sites were selected individually with due consideration for the underlying somatic condition. Good results were achieved in the patients with the fibrous form of chronic aphthous stomatitis. Secretory and serum immunoglobulin levels were monitored over the course of laser treatment.
Subject(s)
Acupuncture Therapy/methods , Laser Therapy , Stomatitis, Aphthous/radiotherapy , Acupuncture Points , Adolescent , Adult , Chronic Disease , Evaluation Studies as Topic , Female , Humans , Male , Middle Aged , RecurrenceABSTRACT
The immunocorrective activity of bonaphthon, an antiviral agent, was studied in 27 patients with chronic diseases of the buccal mucosa (recurrent aphthous stomatitis, lichen ruber planus, Melkersson-Rosenthal's syndrome). Bonaphthon therapy resulted in quite a number of patients in elevation of serum interferon titer and of the titer of specific antiherpetic antibodies. These results evidence that, besides the antiviral effect, bonaphthon is characterized by an immunomodulating effect and is conducive to fortification of the defense potential of the body in patients with stubborn chronic diseases of the buccal mucosa.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Interferon Inducers/therapeutic use , Mouth Diseases/drug therapy , Naphthoquinones/therapeutic use , Adult , Aged , Chronic Disease , Drug Evaluation , Humans , Interferons/blood , Middle Aged , Mouth Diseases/blood , Mouth MucosaABSTRACT
Studies of blood and salivary fibronectin levels and the total biochemical status have revealed poor reparation potentialities of the body in the patients with various diseases of the buccal mucosa coursing along with somatic diseases (cardiovascular and gastrointestinal) in the remission stage. Bearing in mind a significant role of fibronectin in the reparation processes, the authors suggest local fibronectin therapy as part of combined treatment for buccal mucosa diseases.
Subject(s)
Mouth Diseases/immunology , Adult , Fibronectins/analysis , Humans , Immunity, Innate , Middle Aged , Mouth Mucosa , Saliva/chemistryABSTRACT
The authors sum up the experience gained in tactivin therapy of patients with recurrent aphthous stomatitis and analyze the effects of this drug on the patients' cellular and humoral immunity. Thirty patients with various forms of the condition were subcutaneously injected tactivin in a dose of 40 micrograms for 10 days. Biochemical parameters were virtually unchanged after therapy, whereas the immunity parameters evidenced essential shifts in humoral and cellular immunity. Clinical and laboratory data indicate a sufficiently high immunocorrective effect of tactivin in therapy of patients with recurrent aphthous stomatitis.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Peptides/therapeutic use , Stomatitis, Aphthous/drug therapy , Thymus Extracts/therapeutic use , Adult , Antibody Formation/drug effects , Chronic Disease , Drug Evaluation , Female , Humans , Immunity, Cellular/drug effects , Male , Middle Aged , Recurrence , Stomatitis, Aphthous/immunologyABSTRACT
The authors assess the therapeutic efficacy of kemantan, an immunomodulator, used in the treatment of 30 patients with severe stubborn recurrent aphthous stomatitis (RAS). The blood immunological and biochemical characteristics were checked up over the course of treatment. Clinical and laboratory studies have shown that this immunocorrective agent is sufficiently effective for fibrous and cicatrizing RAS running a permanent course: the periods of the pathologic elements epithelialization are shortened, the permanent course of the condition is interrupted and the remissions are prolonged; clinical cure has been achieved in a number of cases. Kemantan is indicated for RAS patients only in cases with immunologic insufficiency, with immunologic responses monitored over the course of the treatment.
Subject(s)
Adamantane/analogs & derivatives , Adjuvants, Immunologic/therapeutic use , Stomatitis, Aphthous/drug therapy , Adult , Antibody Formation/drug effects , Antibody Formation/immunology , Chronic Disease , Drug Evaluation , Female , Humans , Immunity, Cellular/drug effects , Immunity, Cellular/immunology , Male , Middle Aged , Recurrence , Stomatitis, Aphthous/blood , Stomatitis, Aphthous/immunologyABSTRACT
The effect of nonenzymatic fibrinolysis of the blood and its complexes (epinephrine-heparin and serotonin-heparin) on the fibrinolytic activity is shown. An increase in fibrinolytic activity of the blood of patients with chronic relapsing aphthous stomatitis is a protective reaction of the body in distrophic changes. Intensification of fibrinolysis is a factor which aggravates the course of chronic relapsing aphthous stomatitis and inhibits reparative processes during its treatment.
