[The role of chronic colitis in the pathogenesis of Hirschsprung 's disease in children]. / Rol' khronicheskogo kolita v patogeneze bolezni Girshprunga u detei.

The role of chronic colitis in pathogenesis of Hirschsprung's disease was studied ultrastructurally and morphometrically. Morphological features of chronic colitis were revealed by examination of full-layers biopsies and excised fragments of the colon in 26 children aged from 2 to 14 years with Hirschsprung's disease. Atrophic-sclerotic form of colitis develops in various disturbances of colo-rectal innervation. In this condition diffuse sclerosis of bowel wall could be considered as pathognomonic symptom of Hirschsprung's disease. As a result of development of sclerosis insufficiency of the bowel motor function increases.