Subject(s)
Disease Models, Animal , Physical Therapy Modalities , Skin Absorption/physiology , Animals , Benzopyrans/pharmacology , Dimethyl Sulfoxide/pharmacology , Electromagnetic Fields , Humic Substances/pharmacology , Mineral Waters , Mud Therapy , Permeability/drug effects , Permeability/radiation effects , Rats , Reference Values , Skin Absorption/drug effects , Skin Absorption/radiation effectsABSTRACT
Experiments on 130 male lake frogs were made to study a combined action of SHF electromagnetic fields (microwaves) and baths KI + I2, DMSO, KI + I2 + DMSO, iodinol, iodinol + DMSO, humic acids, humic acids + KI + I2, humic acids + DMSO, sapropel + DMSO on excitability and accommodation ability of nervous and muscular tissues. The most perspective combinations (by the number of statistically significant shifts of 6 electrophysiological parameters) were selected for screening on warm-blooded animals. These were SHF microwaves + KI + I2, SHF microwaves + iodinol.
Subject(s)
Electromagnetic Fields , Iodine Compounds/pharmacology , Iodine/pharmacology , Muscles/drug effects , Nerve Tissue/drug effects , Animals , Electrophysiology , Male , Muscles/physiology , Nerve Tissue/physiology , Rana ridibunda , Statistics, Nonparametric , Time FactorsABSTRACT
Experiments on 43 thyroidectomized Wistar male rats with experimental hypothyroidism have shown a favourable effect of iodinole electrophoresis but not galvanization on the disease. The effect was assessed by organ weight and intraorgan water concentration.
Subject(s)
Anti-Infective Agents, Local/administration & dosage , Physical Therapy Modalities/methods , Polyvinyl Alcohol/analogs & derivatives , Animals , Body Water/drug effects , Body Weight/drug effects , Evaluation Studies as Topic , Hypothyroidism/etiology , Hypothyroidism/rehabilitation , Iontophoresis/methods , Male , Polyvinyl Alcohol/administration & dosage , Rats , Rats, Wistar , Tail , ThyroidectomyABSTRACT
As shown by the experiments on 43 normal and postthyroidectomy Wistar female rats, course procedures of molecular iodine electrophoresis promote normalization of rat hypothyrosis whereas galvanization was uneffective.
Subject(s)
Iodine/administration & dosage , Physical Therapy Modalities/methods , Animals , Body Water/drug effects , Electric Stimulation Therapy , Female , Hypothyroidism/physiopathology , Hypothyroidism/rehabilitation , Iontophoresis , Organ Size/drug effects , Physical Therapy Modalities/statistics & numerical data , Rats , Rats, Wistar , Statistics, Nonparametric , ThyroidectomySubject(s)
Cell Membrane/metabolism , Physical Therapy Modalities , Sodium/metabolism , Benzopyrans/pharmacology , Biological Transport, Active/drug effects , Cell Membrane/drug effects , Electromagnetic Fields , Humans , Humic Substances/pharmacology , Mineral Waters , Mud Therapy , Static Electricity , UltrasonicsABSTRACT
Experiments on white rats proved that the silicotic pulmonary changes slowed with the tails periodically immersed into iodine solution. Those pulmonary changes were due to inhalation of quartzite dust and especially due to intratracheal administration of standardized quartz dust DQ12. Influenced by inhalation of dust containing quartz, the rats demonstrated characteristic alterations in cytologic features of bronchial and alveolar lavage water. The "iodine baths" also declined those alterations, that may prove higher resistance of pulmonary macrophages to cytotoxic effects of quartz. This hypothesis finds a support in experiments with culture of rat peritoneal macrophages. If incubated in a medium with low iodine concentrations and subsequently washed off, the macrophages demonstrate lower incidence of cytotoxic effects due to the next incubation with particles of DQ12. The macrophage's higher resistance against cytotoxic agents is believed to result directly in antisilicotic effect of iodine, so "iodine baths" could be recommended for pathogenetic therapy and medical prophylaxis of silicosis.
Subject(s)
Iodine/therapeutic use , Silicosis/prevention & control , Administration, Cutaneous , Animals , Bronchoalveolar Lavage Fluid , Cells, Cultured , Dust/adverse effects , Iodine/administration & dosage , Iodine/pharmacology , Lung/pathology , Macrophages, Peritoneal/drug effects , Male , Quartz/adverse effects , Quartz/pharmacology , Rats , Silicosis/etiology , Silicosis/pathologyABSTRACT
Experiments with male frogs carried out in autumn-winter revealed that the effect of UHF centimeter band electromagnetic field on excitable tissues depends on these tissues functioning. Such an exposure had the most marked effect on animals with destroyed central nervous system and on isolated tissues. On the whole this exposure reduced muscular tissue threshold excitability and resulted in variously directed shifts of these thresholds in nervous tissue. Changes in tissue accommodation capacity under the effect of such electromagnetic field varied in nature and in direction.
Subject(s)
Central Nervous System/radiation effects , Electromagnetic Fields , Animals , Central Nervous System/physiology , Male , Neuromuscular Junction/physiology , Neuromuscular Junction/radiation effects , Rana ridibunda , SeasonsABSTRACT
In biophysical investigations performed on the frog skin with the method of short current it has been shown that molecular iodine (I2) stimulates the active transport of sodium ions in cell membranes and the mixture of KI+I2 (with complex I3-) inhibits this process. The possibility to increase the efficiency of iodine-bromide mineral baths composition with addition of I2 to the solution is experimentally confirmed.
Subject(s)
Cell Membrane/drug effects , Iodine/pharmacology , Sodium/metabolism , Animals , Balneology , Biological Transport, Active/drug effects , Iodine/chemistry , Ion Transport/drug effects , Male , Potassium Iodide/pharmacology , Ranidae , Skin/cytology , Skin/metabolismSubject(s)
Lipid Peroxidation/radiation effects , Lipids/radiation effects , Microwaves/adverse effects , Pancreatitis/blood , Trace Elements/radiation effects , Animals , Chronic Disease , Disease Models, Animal , Lipids/blood , Male , Pancreas/pathology , Pancreas/radiation effects , Pancreatitis/pathology , Rats , Trace Elements/blood , Weight Loss/radiation effectsSubject(s)
Physical Therapy Modalities , Biophysical Phenomena , Biophysics , Electrophysiology , HumansSubject(s)
Microwaves , Muscles/radiation effects , Nerve Tissue/radiation effects , Adaptation, Physiological/physiology , Adaptation, Physiological/radiation effects , Animals , Electric Stimulation/methods , In Vitro Techniques , Muscles/physiology , Nerve Tissue/physiology , Neuromuscular Junction/physiology , Neuromuscular Junction/radiation effects , Rana ridibundaABSTRACT
The experiments on edible frogs have revealed the relationship between the effect of sodium chloride, skin potential difference and micro-components iodide and bromide present in the solution. The results obtained furnish the additional information on the synergistic action of mineral water iodide and bromide on the body. Iodide ions were found to act mainly through inhibition of sodium channels of cellular membranes, while bromide ions are likely to affect Na, K-ATPase.
Subject(s)
Bromides/pharmacology , Iodides/pharmacology , Mineral Waters , Skin/drug effects , Animals , Drug Synergism , In Vitro Techniques , Isotonic Solutions , Male , Membrane Potentials/drug effects , Membrane Potentials/physiology , Rana ridibunda , Ringer's Solution , Skin/cytology , Skin Physiological Phenomena , Sodium Chloride/pharmacology , SolutionsABSTRACT
The experiments on 50 white mature male rats have provided evidence on the effect produced by microwave therapy on lipid peroxidation, lipid and mineral metabolism and weight of the animals. The effect varied with frequency, wavelength and the site of the exposure (abdominal or cervical zones).
Subject(s)
Lipid Peroxidation/radiation effects , Lipids/radiation effects , Microwaves/adverse effects , Trace Elements/radiation effects , Animals , Free Radicals , Lipids/blood , Male , Rats , Trace Elements/bloodABSTRACT
For human skin transcutaneous transport of I ions in vitro depends on sodium chloride-iodide concentration relations in mineral water, whereas such transport for Br ions in mainly determined by absolute concentration of sodium chloride. Optimal proportions of the salts have been specified for I and Br ions transcutaneous transport in definite concentration range. An unknown feature of the mechanism of action of hypertonic salt solutions on ionic skin permeability has been identified. The results are analyzed from the point of view of the ion pairs conception.