ABSTRACT
OBJECTIVE: The purpose was to describe whether there are field cancerization (FC) indicators in clinically normal mucosa opposite to primary oral squamous cell carcinoma (OSCC). METHODS: A search of the Cochrane Library, PubMed, Embase, Web of Science, Scopus, and Livivo databases was performed on June 12, 2022, which retrieved 152 records without duplicates. Studies that analyzed FC in biopsies in clinically normal tissue opposite to primary OSCC were included. The search was conducted under the PRISMA guideline and the protocol was registered in PROSPERO (CRD42017077125). RESULTS: Eight articles with 302 patients were included, 192 men and 110 women, mean age 57.1 years. Most patients had deleterious habits. All studies performed histopathological confirmation of OSCC and biopsies were obtained the clinically normal mirror mucosa. The meta-analysis carried out with eight studies. The studies showed 57.3 % of cases with histopathological changes of clinically normal mucosa opposite to primary OSCC (Confidence interval 95 %, 0.443-0.703; heterogeneity: Q value 18.715; I2 73.284 %; n = 205). p53 and Ki-67 immunohistochemical analysis may be predictive for detecting changes. There was p53 immunoexpression in 41.3 % of cases (p = 0.872) (n = 55), ki-67 immunoexpression (< 20 %) in 68 % (p = 0.001) (n = 97) and ki-67 immunoexpression (> 20 %) in 28.4 % of cases (p = 0.000) (n = 110). CONCLUSIONS: The findings suggest that FC can occur, and there are histopathological changes in clinically normal tissue opposite to primary OSCC. Nevertheless, the review showed that more longitudinal studies on FC are needed to draw a conclusive indication of the occurrence of FC in oral tissues opposite to OSCC.
Subject(s)
Carcinoma, Squamous Cell , Mouth Neoplasms , Carcinoma, Squamous Cell/pathology , Female , Humans , Ki-67 Antigen , Male , Middle Aged , Mouth Mucosa/pathology , Mouth Neoplasms/pathology , Tumor Suppressor Protein p53ABSTRACT
RESUMO A odontodisplasia regional é uma anomalia dentária, pouco comum, não hereditária e com uma etiologia ainda desconhecida. Os tecidos afetados são o esmalte e a dentina, são acometidos nos dentes decíduos e, as vezes na dentição permanente de um mesmo indivíduo. Esta lesão pode ser confundida com outras lesões como por exemplo o odontoma ou dentes com outro tipo de anomalia. O objetivo é relatar um caso de odontodisplasia regional na dentição decídua e permanente de uma criança, assim como apresentar as diferentes ferramentas diagnósticas. Os dentes acometidos mostravam-se ao exame clínico, como dentes hipoplásicos com coloração amarelo amarronzado. Uma radiografia panorâmica e radiografias periapicais, assim como uma biopsia excisional, foram essenciais para obter um diagnóstico correto, e assim poder oferecer uma adequada conduta para a preservação e previsibilidade dos diferentes tipos de tratamentos reabilitadores odontológicos que essa criança poderia ter nos próximos anos até a idade adulta.
SUMMARY Regional odontodysplasia is an uncommon dental anomaly that is not hereditary and has a still unknown etiology. The affected tissues are enamel and dentin, the primary teeth are affected, and sometimes in the permanent dentition of the same individual. This lesion may be confused with other lesions such as odontoma or teeth with another type of anomaly. The objective is to report a case of regional odontodysplasia in the deciduous and permanent dentition of a child, as well as to present the different diagnostic tools. The affected teeth showed clinical examination, such as hypoplastic teeth with a yellow-brown coloration. A panoramic radiograph and periapical radiographs, as well as an excisional biopsy, were essential to obtain a correct diagnosis, so as to be able to offer an adequate conduct for the preservation and predictability of the different types of dental rehabilitation treatments that this child could have in the years to come adulthood.
ABSTRACT
OBJECTIVES: This study investigated the association of congenital cervical vertebrae anomalies (CVA) with the prevalence of cleft lip and palate (CLP) specifying the most frequent associations. METHODS: A meta-analysis was based on the Preferred Reporting Items of Systematic reviews and Meta-Analyses guideline. A search of the PubMed, Embase, Web of Science, Science Direct, Scopus and Lilacs database was performed until March 2018. Clinical studies that evaluated CVA in individuals with CLP (experimental group) and without CLP (control group) was included. For the statistical analysis, the software Comprehensive Meta-Analysis (Biostat; Englewood, NJ) was used, with a p-value < 0.05 considered significant. RESULTS: A total of 10 articles were included, for a total of 2566 individuals with CLP and 2301 individuals without CLP. The meta-analysis indicated statistically significant differences and the group of individuals with CLP had an increased number of CVA when compared to the group of individuals without CLP (p < 0.05; 95% confidence interval, 2.41-6.11; heterogeneity: Q-value 32.8, I2 72.6%). CONCLUSIONS: This study indicated that CVA are associated with the presence of CLP. Among the patients with CVA the most frequent anomalies were the deficiency of the posterior arch, followed by the fusion of cervical vertebrae. Individuals with cleft palate and those with unilateral cleft lip and palateCLP had an increased prevalence of CVA.
Subject(s)
Cervical Vertebrae , Cleft Lip , Cleft Palate , Cervical Vertebrae/abnormalities , Cleft Lip/complications , Cleft Palate/complications , Humans , PrevalenceABSTRACT
Objetivo: avaliar a eficácia do levantamento do seio maxilar atraumático sem enxerto ósseo e a taxa de sobrevivência da instalação de implantes imediatos. Material e métodos: realizou-se uma estratégia de busca nas bases de dados Pubmed, Web of Science e Science Direct, obtendo 103 artigos, sendo selecionados 07 estudos publicados entre 2008 até 2019. Resultados: foram registrados 576 pacientes com idades entre 19 e 85 anos de idade, de ambos os sexos e 1,113 implantes instalados. Verificou-se uma taxa de sucesso e sobrevivência dos implantes de 96,6%, após um seguimento de 1 a 3 anos e houve um ganho ósseo de aproximadamente 3mm. Considerações finais: o levantamento de seio maxilar atraumático sem enxerto ósseo é eficaz para reabilitação de áreas edêntulas e mostra um bom resultado ao longo do tempo, com uma taxa média de sobrevivência dos implantes de 96,3%. Ainda faltam estudos para determinar qual tipo de implante é melhor para este tipo de técnica. (AU)
Objective: To assess the efficacy of atraumatic maxillary sinus augmentation without bone grafting and the survival rate of the immediate implant installation. Material and methods: A search strategy was performed the in Pubmed, Web of Science, and Science Direct databases, resulting in 103 articles from which seven studies published between 2008 and 2019 were selected. Results: 576 patients of both sexes, aged between 19 and 85 years, were registered, as well as 1,113 implants installed. There was a success rate and survival of implants of 96.6% after a follow-up of 1 to 3 years and there was a bone gain of approximately 3 mm. Final considerations: The atraumatic maxillary sinus augmentation without bone graft is effective to rehabilitate edentulous areas and shows a good outcome over time, with an average rate of implant survival 96.3%. Further studies are still required to determine which type of implant is best for this type of technique.(AU)
